The North Jersey ACS NMR Topical Group is pleased to present its February meeting online, Thurs, February 24, 7:00 pm 

Featured Presentation

Keith Fritzsching, PhD

Seminar details:

Date: Thursday February 24th 7:00 pm ET

Speaker: Dr. Keith Fritzsching
Senior Member –Technical Staff
Sandia National Laboratories

Title: “Structure and Chemical Kinetics of Heterogenous Biomolecular Assemblies with Solid-State NMR”

Flyer: [ 2022-02-17-NMR-flyer.pdf ]


Solid-state NMR can be used to measure atomic-resolution structure and chemical kinetics in a broad range of systems, including those that lack periodicity, have defects, or otherdisorders. I will dicuss biophysics studies where detailed local conformational information is attenable despite long-range (nm-µm) disorder. I will highlight our recent study of TIA1, aprotein involved in several neurodegenerative diseases. Even in this large (43kDa) and complex protein, we could obtain site-specific information necessary for understanding the protein’s mechanisms and ligand binding. I will also discuss several Solid-state NMR methods development projects. I will introduce a class of recoupling pulse sequences that use an “interleaving” scheme to tune effective Hamiltonian scaling factors.

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This will be a virtual meeting hosted via Microsoft Teams.

The seminar is free of charge. No advance registration is required.

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