2019 Spring Symposium & Vendor Exhibition

Sponsored by the

North Jersey ACS Drug Metabolism Discussion Group

“From Small Molecule to Large – Modality Expansion and Impact within Drug Disposition

Date:   May 9, 2019

Time:   8:00 am – 4:00 pm

Venue:  The Palace at Somerset Park,
        333 Davidson Avenue,
        Somerset, NJ 08873     [ directions ]

Registration Information:

  • Pre-registration fee is $125 (pre-register by May 2, 2019).
  • Registration fee at the door is $150 (Checks only)
  • Registration fee is $10 for students and postdocs and $50 for faculty
  • Registration is free for unemployed

Please plan to pre-register as a group, as coordinated by a member of the NJACS DMDG Steering Committee List, below, from your organization.

  • If you have no DMDG member at your company, please contact Elizabeth Joshi (elizabeth.joshi@merck.com) for registration.
  • Payments by personal or company checks. Sorry, credit cards are not accepted.
  • Checks should be made payable to: NJ Drug Metabolism Discussion Group.




“From Small Molecule to Large – Modality Expansion and Impact within Drug Disposition

 8:00 a.m.

                        Registration / Continental Breakfast / Vendor

 9:00 a.m.


Elizabeth Joshi, Chair, NJ DMDG

 9:15 a.m.

The Role of
DMPK in Supporting Therapeutic Proteins in a Drug Discovery Setting

Larry Wienkers, PhD, Principal
Scientist, Wienkers Consulting

 10:00 a.m.

Applications of Minimal PBPK Models to
Understand the Effect of FcRn on Monoclonal

Antibody System Persistence

Yanguang (Carter) Cao, Ph.D., Assistant Professor | Division
of Pharmacotherapy and Experimental Therapeutics | UNC Eshelman School of Pharmacy

 10:45 a.m.

Exhibit & Coffee Break

 11:15 a.m.

Prediction of in vivo
molecular stability of protein therapeutics through in vitro assessment of
kinetic stability

Kevin Cook, Senior Scientist – PKDM, Amgen

 12:00 p.m.

& Vendor Exhibit

 1:15 p.m.

Preclinical PK/TE/PD Approach and Application
for First-in-Human Dose Selection of a Therapeutic Antibody Targeting a
Checkpoint Receptor

Yanbin Lao, PhD, Principal Research Scientist, Eli Lilly and Company

 2:00 p.m.

Engineered “Smart” Insulin:
Insulin-Carbohydrate Conjugates with Responsivity to Physiological Levels of

SongnianLin , PhD, Director – Discovery Chemistry, Merck Research Laboratories,
Kenilworth, NJ

 2:45 p.m.

            Vendor Exhibit & Coffee Break

 3:00 p.m.

Digital nano: Rational
Design of Biocompatible Nanomaterials by Virtual Nano Library Techniques and
Artificial Intelligence

Hao Zhu, Associate Professor – Chemistry, Rutgers University, New
Brunswick, NJ

 3:45 p.m.

                          Program closure

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NJ-DMDG Steering Committee 2019-2020
Name Company E-mail address Responsibility
Beth Joshi Merck elizabeth.joshi@merck.com Chair, 2018-19
Imad Hanna Novartis imad.hanna@novartis.com Chair Elect, 2019-20
Matthew Hoffmann Celgene mjhoffman@celgene.com Treasurer
Naiyu Zheng BMS naiyu.zheng@bms.com Vendor Liaison
Manthena Varma Pfizer Manthena.V.Varma@pfizer.com Past Chair, 2017-18
Bo Wen GSK bo.1.wen@gsk.com Past Chair, 2016-17
Lauren Aleksunes Rutgers University aleksunes@eohsi.rutgers.edu Past Chair, 2015-16
Wing Lam Janssen R&D wlam@its.JnJ.com Past Chair, 2013-14
Allen Jones allen.n.jones@verizon.net Past Chair, 2012-13
Anima Ghosal Kean University ghosala@aol.com Member
Ron Kong PTC Therapeutics rkong@ptcbio.com Member
Lei Tang Sanofi Lei.Tang@sanofi.com Member
Li Yu Roche li.yu.ly1@roche.com Member
Fan Wu Celgene fwu@celgene.com Member
Jin Wu Merck Jin_wu@merck.com Member
Zhao pie Zeng zhaopiezeng@gmail.com Member
Carolina Berthiaume carolina.berthiaume@gmail.com Member
Maria Markowska Mmaryla5@yahoo.com Member



Directions to the Palace at Somerset Park

    333 Davidson Avenue, Somerset, NJ 08873

    Phone: 732-302-9922
    [ website ]

From the New Jersey Turnpike:

    Exit 10 to Interstate 287 North.
    Follow 10 miles to Exit 10 (527 New Brunswick — South Bound Brook).
    Take Easton Ave towards South Bound Brook to first light,
    make left (Davidson Ave.)

From New York City:

    Lincoln Tunnel to N.J. Turnpike South.
    Follow N.J. Turnpike directions mentioned above.

From Route 287:

    If traveling north:

      Exit 10 (527 New Brunswick — South Bound Brook).
      Follow sign towards Bound Brook, to light
      make left (Davidson Ave.)
    If traveling south:

      Exit 10 (527 New Brunswick).
      Left on Easton Ave., to light,
      make left (Davidson Ave).

From Newark Airport:

    Take NJ Turnpike South to Exit 10
    I-287 North to Exit 10 (Easton Ave)
    at first light, go left on Davidson Ave.
    Hotel immediately on left.