NMR Spectroscopy

About / Overview

The mission of the NJ-ACS NMR TG is to bring together scientists who use nuclear magnetic resonance (NMR) as a research tool from academia and industry, students of NMR, as well as vendors of NMR-related products. It organizes monthly meetings that consist of a social hour, a buffet dinner, followed by a presentation by an invited speaker.

From time to time, the NMR Topical Group hosts scientific symposia on topics related to nuclear magnetic resonance (NMR). These events serve as excellent venues for networking within the local scientific community. Also, through its activities, the NMR Topical Group raises public awareness of the American Chemical Society (ACS) and its service to the scientific community.

The NMR Spectroscopy Topical Group operates under the auspices of the North Jersey Section of the American Chemical Society (NJ-ACS), which is a non-profit organization that qualifies for tax exempt status under section 501(c)(3) of the Internal Revenue Service code.

Board Members

Christine Jorge

Christine Jorge

Chair

Rongfeng Zheng

Rongfeng Zheng

Co-Chair

Tom Osborn Popp

Tom Osborn Popp

Past Chair

Prof. Gaetano Montelione, Ph.D.

Prof. Gaetano Montelione, Ph.D.

Scientific Advisor

Luciano Mueller, Ph.D.

Luciano Mueller, Ph.D.

Scientific Advisor

NMR Seminar: Structural Determination of Neurodegenerative Disease-Associated Proteins Inside Cells

February 22, 2024 | 12pm - 1pm

 Abstract

The misfolded proteins associated with neurodegenerative disease can adopt a variety of different conformations, some of which are toxic. Because these proteins have identical amino acid sequences, the cellular environment clearly influences the final state, yet most structural studies do not include the cellular context and, perhaps because we are not studying the correct conformation, not a single therapeutic strategy for these diseases addresses the underlying protein misfolding pathology. Using new sensitivity-enhancement technology for solid state NMR spectroscopy, Dynamic Nuclear Polarization, we study protein structure in native environments -inside living cells -to reveal how both healthy and disease-relevant cellular environments influence protein structure. Because NMR reports quantitatively, with atomic level precision, on all sampled conformation, it can not only report on structural polymorphs but also provide experimental restraints on regions of intrinsic disorder, complementing insights from cryo-electron microscopy and tomography.Using this approach, we recently demonstrated that an amyloid fibril with a solved cryo-EM structure was polymorphic and found that when those fibrils were used to seed amyloid propagation in mammalian cells, the minority polymorph in the purified setting became the majority polymorph inside cells. With this approach we can understand the mechanism of protein-based inheritance of amyloid aggregates and correlate phenotype withconformational ensembles.

 Connection Information
This will be a virtual meeting hosted via Microsoft Teams. A direct link to the meeting is located here

 Please reach out to Christine Jorge (christine.jorge@bms.com) or Rongfeng Zheng (rongfeng.zheng@bms.com) with any questions

Save the Date

Meeting Archives

  • Feb 23, 2023 – NMR Topical Group Meeting

    The North Jersey ACS NMR Topical Group is pleased to present its January meeting online, Thu, February 23, 12:00 noon ET, via Microsoft Teams. Featured Presentation Seminar details: Date: Thursday February 23 at 12:00 noon ET Speaker: Gregory P...
  • Jan 27, 2023 – NMR Topical Group Meeting

    The North Jersey ACS NMR Topical Group is pleased to present its January meeting online, Fri, January 27, 12:00 noon ET, UNDER CONSTRUCTIONvia Microsoft Teams.  (Note: This meeting was originally listed for Thurs Jan 26)  Featured Presentation S...
  • Oct 24, 2022 – NMR Symposium

    North Jersey ACS NMR Topical Group presents its Annual NMR Symposium Monday October 24th, 2022 Frick Chemistry Building Princeton University, Princeton, NJ 08544 [ directions | register | flyer ] The Symposium and dinner are FREE of charge to all attendees * * * * * * * * * * * * * * * * *...
  • Sep 22, 2022 - Sept 29, 2022 – NMR Topical Group Meeting

    The North Jersey ACS NMR Topical Group is pleased to present its September meeting in-person, Thurs, September 29, 2022, 6:00 pm  Featured Presentation “Making the Most of the D1 Delay” Speaker: Nicole Kruse, Bruker BioSpin Date:  ...
  • May 19, 2022 – NMR Topical Group Meeting

    The North Jersey ACS NMR Topical Group is pleased to present its May meeting online, Thurs, May 19, 12:00 noon ET  UNDER CONSTRUCTION Featured Presentation Seminar details: Date: Thursday May 19th at 12:00 noon ET Speaker: Prof. David A. Case Department of...

Resources

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NMR Group History

NMR Spectroscopy Group History

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NMR Group News

NMR Spectroscopy Group News

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Bristol-Myers Squibb

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ACD/Labs

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Cambridge Isotope Laboratories

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JEOL

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Oxford Instruments

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Mestrelab Research

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Bruker BioSpin

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New Era Enterprises

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Magritek

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Icon Isotopes

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Dr. Luciano Müller

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Wilmad-LabGlass

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Suraj Manrao Science Fund

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Sigma-Aldrich/Isotec

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CortecNet

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