Role of water and deep eutectic solvent additives in making SFC greener
ABSTRACT
SFC is typically considered as a greener technique compared to HPLC due to the use of supercritical carbon dioxide as the majority mobile phase. However, to increase the breadth of samples that could be possibly separated by SFC, organic modifiers are added (from 5-70%) to the carbon dioxide. Both in industry and academia SFC is majorly used for the separation of enantiomers. With environmental impacts of processes coming to the forefronts we are now faced with challenges to make further improvements to said processes. This talk will go into details regarding the addition of small quantities of water to SFC mobile phase. Effect of water, include not only increases in chromatographic figures of merit but also makes it greener by decreasing the amount of organic modifier required. The effects of water on different types of stationary phases with different surface chemistries will be discussed in order to further understand when water addition is suitable. Furthermore, the utility of a new class of additives- ‘non-toxic deep eutectic solvents’ as additive in SFC will also be discussed.
BIOGRAPHY
Daipayan Roy is currently a Senior Scientist at Amgen working in the Synthetics Separations group which provides analytical and purification support to early stage drug discovery. His work focuses on enantiomeric separations using supercritical fluid chromatography (SFC). He currently has 14 publications in various leading analytical chemistry journals. Prior to joining Amgen Dr. Roy received his PhD from University of Texas at Arlington in 2020 under the guidance of Dr. Daniel W. Armstrong where his work focused on chiral separations using macrocyclic glycopeptide stationary phases.
