North Jersey Section
American Chemical Society

NMR Spectroscopy Topical Group Meetings

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(Recent Event)

May 19, 2022 – NMR Topical Group Meeting

The North Jersey ACS NMR Topical Group is pleased to present its May meeting online, Thurs, May 19, 12:00 noon ET 


Featured Presentation

David A. Case

Seminar details:

Date: Thursday May 19th at 12:00 noon ET

Speaker: Prof. David A. Case
Department of Chemistry & Chemical Biology
Rutgers University

Title: “Connecting Chemical Shifts to Structure for Proteins and Nucleic Acids”

Flyer: [ 2022-05-19_NJACS_Dave-Case.pdf ]

Abstract

An automated fragmentation quantum mechanics/molecular mechanics approach (AFNMR) has shown promising results in chemical shift calculations for biomolecules. Trends in chemical shift are stable with regards to change in density functional or basis sets, and the use of the small “pcSseg-0” basis, which was optimized for chemical shift prediction, opens the way to more extensive conformational averaging, which can often be necessary, even for fairly well-defined structures. There have also been recent advances in the use of machine learning approaches to develop empirical connections to structure. I will discuss prospects for using both types of calculations to gain insights into biomolecular structure and dynamics. 

Connection Information

This will be a virtual meeting hosted via Microsoft Teams.

The seminar is free of charge. No advance registration is required.

Link to the meeting (uses Microsoft Teams):

https://njacs.org/nmr-meetup

Questions:

Jonathan.Williams@bms.com (Chair)
Thomas.OsbornPopp@rutgers.edu (Co-Chair)

Microsoft Teams meeting

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Click here to join the meeting: https://njacs.org/nmr-meetup

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+1 908-409-1059,,470936412# United States, Elizabeth NJ

(833) 733-5876,,470936412# United States (Toll-free)

Phone Conference ID: 867 963 351#

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2022-05-19

(Past Events)

Apr 21, 2022 – NMR Topical Group Meeting

The North Jersey ACS NMR Topical Group is pleased to present its April meeting online, Thurs, April 21, 12:00 noon ET 


Featured Presentation

Claudia Avalos

Seminar details:

Date: Thursday April 21st at 12:00 noon ET

Speaker: Prof. Claudia Avalos
Department of Chemistry
New York University

Title: “Improving the Spatial Specificity and Sensitivity of NMR

Flyer: [ 2022-04-21-NMR-Claudia_Avalos.pdf ]

Abstract

In this presentation I will review advances in the detection of surfaces and interfaces using solid-state NMR and how these techniques have been applied in materials science. In particular, I will discuss NMR signal enhancement using cross-effect dynamic nuclear polarization (DNP), as well as methods for generating non-equlibrium electron spin polarization optically with nitrogen-vacancy (NV) centers in diamond and designer chromophore-radical systems. 

Connection Information

This will be a virtual meeting hosted via Microsoft Teams.

The seminar is free of charge. No advance registration is required.

Link to the meeting (uses Microsoft Teams):

https://njacs.org/nmr-meetup

Questions:

Jonathan.Williams@bms.com (Chair)
Thomas.OsbornPopp@rutgers.edu (Co-Chair)

Microsoft Teams meeting

Join on your computer or mobile app

Click here to join the meeting: https://njacs.org/nmr-meetup

Or call in (audio only)

+1 908-409-1059,,478660434# United States, Elizabeth NJ

(833) 733-5876,,478660434# United States (Toll-free)

Phone Conference ID: 867 963 351#

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2022-04-21

(Past Events)

Mar 24, 2022 – NMR Topical Group Meeting

The North Jersey ACS NMR Topical Group is pleased to present its March meeting online, Thurs, March 24, 7:00 pm 


Featured Presentation

Seminar details:

Date: Thursday March 24th 7:00 pm ET

Speaker: Prof. Galia Debelouchina
Department of Chemistry & Biochemistry
University of California, San Diego

Title: “NMR-Based Tools for Structural Biology of Complex Systems: From Gels to Cells”

Flyer: [ 2022-03-24-NMR-flyer.pdf ]

Abstract

Recent advances in structural biology have dramatically expanded the scope of proteins and assemblies that are now amenable to structural analysis. Yet, many biological systems display dynamics and undergo transformations that have been difficult to capture experimentally, especially in complex or native settings. In this context, my group has been developing NMR-based methodologies to describe such challenging systems and to pave the way to the next exciting structural biology frontier, the cellular environment. Here, I will present our progress on two fronts: 1) Development of NMR methodologies to describe the molecular basis of protein phase transitions from the liquid to the gel and solid states. In particular, I will focus on the transitions displayed by heterochromatin protein 1α (HP1α), a key player in gene regulation and chromatin organization. 2) Development of sensitivity-enhanced NMR approaches suitable for the cellular environment. Our work is based on a methodology called dynamic nuclear polarization (DNP) which can transfer polarization from electron to nuclear spins and thus increase nuclear signals by several orders of magnitude. For this purpose, we develop small molecule DNP polarization agents that contain unpaired electron spins and that can be targeted selectively to a protein of interest. These agents have allowed us to obtain NMR structural data of tiny amounts of proteins (1-5 μg) and to study the  polarization transfer mechanisms in targeted DNP experiments.

Connection Information

This will be a virtual meeting hosted via Microsoft Teams.

The seminar is free of charge. No advance registration is required.

Link to the meeting (uses Microsoft Teams):

https://njacs.org/nmr-2022-03-24

Questions:

Jonathan.Williams@bms.com (Chair)
Thomas.OsbornPopp@rutgers.edu (Co-Chair)

Microsoft Teams meeting

Join on your computer or mobile app

Click here to join the meeting

Or call in (audio only)

+1 908-409-1059,,867963351# United States, Elizabeth NJ

(833) 733-5876,,867963351# United States (Toll-free)

Phone Conference ID: 867 963 351#

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Audio for this meeting can be heard in the Microsoft Teams client. Please check your audio device settings before you join the call. If you see phone numbers above, you can use them to join the meeting’s audio if necessary.

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2022-03-24

(Past Events)

Feb 24, 2022 – NMR Topical Group Meeting

The North Jersey ACS NMR Topical Group is pleased to present its February meeting online, Thurs, February 24, 7:00 pm 


Featured Presentation

Keith Fritzsching, PhD

Seminar details:

Date: Thursday February 24th 7:00 pm ET

Speaker: Dr. Keith Fritzsching
Senior Member –Technical Staff
Sandia National Laboratories

Title: “Structure and Chemical Kinetics of Heterogenous Biomolecular Assemblies with Solid-State NMR”

Flyer: [ 2022-02-17-NMR-flyer.pdf ]

Abstract

Solid-state NMR can be used to measure atomic-resolution structure and chemical kinetics in a broad range of systems, including those that lack periodicity, have defects, or otherdisorders. I will dicuss biophysics studies where detailed local conformational information is attenable despite long-range (nm-µm) disorder. I will highlight our recent study of TIA1, aprotein involved in several neurodegenerative diseases. Even in this large (43kDa) and complex protein, we could obtain site-specific information necessary for understanding the protein’s mechanisms and ligand binding. I will also discuss several Solid-state NMR methods development projects. I will introduce a class of recoupling pulse sequences that use an “interleaving” scheme to tune effective Hamiltonian scaling factors.

Connection Information

This will be a virtual meeting hosted via Microsoft Teams.

The seminar is free of charge. No advance registration is required.

Link to the meeting (uses Microsoft Teams):

https://njacs.org/nmr-2022-02-24

Questions:

Jonathan.Williams@bms.com (Chair)
Thomas.OsbornPopp@rutgers.edu (Co-Chair)

Microsoft Teams meeting

Join on your computer or mobile app

Click here to join the meeting

Or call in (audio only)

+1 908-409-1059,,867963351# United States, Elizabeth NJ

(833) 733-5876,,867963351# United States (Toll-free)

Phone Conference ID: 867 963 351#

Find a local number | Reset PIN

Audio for this meeting can be heard in the Microsoft Teams client. Please check your audio device settings before you join the call. If you see phone numbers above, you can use them to join the meeting’s audio if necessary.

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2022-02-24

(Past Events)

Jan 20, 2022 – NMR Topical Group Meeting

The North Jersey ACS NMR Topical Group is pleased to present its January meeting online, Thurs, January 20, 7:00 pm 


Featured Presentation

Dr Tom Popp

Seminar details:

Date: Thursday January 20th 7:00 pm ET

Speaker: Dr. Tom Popp
NMR Topical Group Co-Chair 2022
Rutgers University
Department of Chemistry & Chemical Biology

Title: “Development of NMR Instrumentation to Study Complex Materials”

Flyer: [ 2022-01-20-NMR-flyer.pdf ]

Abstract

Many functional inorganic and biological materials are also highly complex in structure and composition on length scales of nanometers or greater. Solid state NMR is particularly well-suited to study these materials, due to its ability to observe local structure and site-specific dynamics. In this talk, I will share how solid-state NMR can be used to reveal new details about complex materials ranging from crystalline, porous metal-organic frameworks (MOFs) to arthropod silk and bacterial biomass. I will also describe new developments in solid state NMR instrumentation, including a new paradigm for magic-angle spinning (MAS) experiments: spherical MAS rotors.

Connection Information

This will be a virtual meeting hosted via Microsoft Teams.

The seminar is free of charge. No advance registration is required.

Link to the meeting (uses Microsoft Teams):

https://njacs.org/nmr-2022-01-20

Questions:

Jonathan.Williams@bms.com (Chair)
Thomas.OsbornPopp@rutgers.edu (Co-Chair)

Microsoft Teams meeting

Join on your computer or mobile app

Click here to join the meeting

Or call in (audio only)

+1 908-409-1059,,867963351# United States, Elizabeth NJ

(833) 733-5876,,867963351# United States (Toll-free)

Phone Conference ID: 867 963 351#

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Audio for this meeting can be heard in the Microsoft Teams client. Please check your audio device settings before you join the call. If you see phone numbers above, you can use them to join the meeting’s audio if necessary.

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2022-01-20

(Past Events)

Oct 18, 2021 – NMR Virtual Symposium

The North Jersey ACS NMR Topical Group is pleased to presents its 2021 Fall Symposium online on Mon, Oct 18, 2021, 8:00 am – 6:00 pm (UTC -4)

North Jersey ACS NMR Topical Group

presents the

2021 Virtual NMR Symposium

October 18th, 2021

Microsoft Teams link: [ https://njacs.org/nmr-webinar ]

Attendance is FREE of charge

Please circulate our [ flyer ]

Please [ register here ] for this symposium
Note:  You can view complete videos of these talks by clicking the video links below.

Program

Session 1 (8:00 – 10:00am EDT)
8:10 – 9:00am -  Christian Griesinger, Max Planck Institute  [ video ]
Title: TBA
9:05 – 9:55am   Matthias Ernst, ETH Zurich  [ video ]
Residual Dipolar Line Width in Proton MAS Solid-State NMR
9:55 – 10:15am – Break

Session 2 (10:15 – 12:05pm EDT)
10:20 – 11:10am -  Lewis Kay, University of Toronto  [ video ]
Developing the NMR toolkit to study protein molecules in the phase separated state
11:15 – 12:05pm  -  Ann McDermott, Columbia University  [ video ]
Signaling in Biological Systems – Insights from NMR
12:05 – 1:00 pm  -  Lunch Break

Session 3 (1:00 – 2:40pm EDT)
1:05 – 1:45pm  - Nicholas Whiting, Rowan University  [ video ]
Advances in Hyperpolarized Magnetic Resonance
1:50 – 2:40pm  -  Qi Zhang, University of North Carolina at Chapel Hill  [ video ]
Unveiling the “Invisible” Regulatory States in RNA
2:40 – 3:00pm – Break

Session 4 (3:00 – 4:50pm EDT)
3:05 – 3:55pm  -  Andrew Nieuwkoop, Rutgers University  [ video ]
Using NMR and Molecular Dynamics to Understand Protein Lipid Interactions
4:00 – 4:50pm  - David Rovnyak, Bucknell University  [ video ]
The metabolome in the freezer: promises and pitfalls of mining metabolic knowledge in standard-of-care biobanked sera, and other unconventional NMR metabolomics
4:50 – 5:10pm – Break

Evening Keynote (5:10 – 6:30pm EDT)
5:25 – 6:15pm – Gerhard Wagner, Harvard University   [ video ]
From NMR studies of translation initiation factors to understanding and targeting cancer
6:20 – 6:30pm – Jon Williams, Co-Chair of the NJACS NMR Topical Group
Closing remarks

We acknowledge the generous support of our sponsors:

Bruker         Cambridge Isotope Laboratories       JEOL       BMS       Luciano Mueller       Icon Isotopes       Wilmad LabGlass       Nexomics Biosciences     CortecNet     ACD Labs     Suraj Manrao Science Fund     Mestrlab Research     Oxford Instruments       New Era     Magritek, Ltd       Millipore Sigma    

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2021-10-18

(Past Events)

Sept 23, 2021 – NMR Topical Group Meeting

The North Jersey ACS NMR Topical Group is pleased to present its September meeting online, Thurs, September 23, 2021, 7:00 pm 


Featured Presentation

Dr James Kempf

Seminar details:

Date: Thursday September 23rd 7:00 pm ET

Speaker: Dr. James Kempf, Product Manager for Hyperpolarization at Bruker Biospin

Title: “Nuclear magnetic resonance and hyperpolarization”

Slides: [ PDF ]

Abstract

Nuclear magnetic resonance, with focus on hyperpolarization. Responsibility for product development in dissolution DNP, parahydrogen, brute-force hyperpolarization and other emerging methods in nuclear spin hyperpolarization. Leading internal R&D and external co-development and testing through customer collaborations. [ slides ]

This seminar is free of charge and sponsored by

Bruker

Link to the meeting (uses Microsoft Teams):

https://njacs.org/nmr-2021-09-23

Registration

Please [ register here ] for this meeting

Questions:

Bradley.Falk@bms.com (Chair)
Jon.Williams@rutgers.edu (Co-Chair)

Microsoft Teams meeting

Join on your computer or mobile app

Click here to join the meeting

Or call in (audio only)

+1 908-409-1059,,402833072# United States, Elizabeth

(833) 733-5876,,402833072# United States (Toll-free)

Phone Conference ID: 402 833 072#

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Audio for this meeting can be heard in the Microsoft Teams client. Please check your audio device settings before you join the call. If you see phone numbers above, you can use them to join the meeting’s audio if necessary.

Learn More | Meeting options

2021-09-23

(Past Events)

May 27, 2021 – NMR Topical Group Meeting

The North Jersey ACS NMR Topical Group is pleased to present its May meeting online, Thurs, May 27, 2021, 7:00 pm 


Featured Presentation

Nikolaos Sgourakis

Seminar details:

Date: Thursday May 27th 7:00 pm ET

Speaker: Nikolaos Sgourakis, University of Pennsylvania

Title: “Leveraging methyl probes for studies of immune complexes by solution NMR”

The seminar is free of charge and sponsored by NJACS NMR Topical Group.

Link to the meeting (uses Zoom Webinar):

https://njacs.org/nmr-2021-05-27

Questions:

Bradley.Falk@bms.com (Chair)
Jon.Williams@rutgers.edu (Co-Chair)

2021-05-27

(Past Events)

Apr 29, 2021 – NMR Topical Group Meeting

The North Jersey ACS NMR Topical Group is pleased to present its April meeting online, Thurs, April 29, 2021, 7:00 pm 


Featured Presentation

Seminar details:

Speaker: Ivan V. Sergeyev, Bristol Myers Squibb

Title: “Dynamic Nuclear Polarization: From Niche Technique to Essential Tool”

Abstract

NMR as a whole, but especially solid-state NMR, can be classed as a “signal-limited” technique – with limited sample volumes, compromises must be made between signal-to-noise ratio and experimental acquisition times. In recent years, a sensitivity revolution has enabled orders-of-magnitude signal enhancements, up to a theoretical maximum of 660- fold, via the Dynamic Nuclear Polarization (DNP) technique. In enabling the gradual easing of the aforementioned compromises, DNP-enhanced SSNMR has enabled studies of systems not previously amenable to solid-state NMR, including whole viruses, amyloid fibrils, membrane proteins, and complex multi-component materials. Yet, the “there is no such thing as a free lunch” mantra also applies — DNP-NMR is not without its pitfalls, generally requiring specialized hardware and modifications to the sample that can impact spectral resolution. Extensive efforts have gone into mitigating these pitfalls and maximizing the sensitivity gains available, especially as the field moves to ever higher magnetic fields. Recent investigations of previously under-explored facets of the technique, for instance direct enhancement of nuclei other than 1H, hint that we have only scratched the surface in terms of the capabilities and potential of DNP. In this talk, I will present:
  • An overview of the technology and mechanisms behind DNP, including recent advances at high magnetic field and low microwave power
  • A brief practical discussion of the state-of-the-art in sample preparation for various DNP applications
  • Recent work in 19F-DNP, with potential implications for the field as a whole
  • Perspectives for the future: combining DNP, ultrafast magic angle spinning (MAS), and selective excitation to revolutionize sensitivity and resolution

Time:
7:00 – 8:00pm, 4/29/2021 EST
The seminar is free of charge and sponsored by NJACS NMR Topical Group

Link to the webinar (uses Microsoft Teams):

https://njacs.org/nmr-2021-04-29

Register

Please [ register here ] for this meeting

Questions:

Bradley.Falk@bms.com (Chair)
Jon.Williams@rutgers.edu (Co-Chair)

Microsoft Teams meeting

Join on your computer or mobile app

Click here to join the meeting

2021-04-29

(Past Events)

Mar 25, 2021 – NMR Topical Group Meeting


The North Jersey ACS NMR Topical Group is pleased to present its March meeting online, Wed, Mar 25, 2021, 7:00 – 8:00 pm 


Yongchao Su

Featured Presentation

Speaker: Yongchao Su, Google Scholar [ yongchao.su@merck.com ]

Title: “Investigating Molecular Mechanisms of Drug Delivery and Stability from Solid-state NMR

Abstract

Structural details often provide molecular mechanisms to construct the interplay among biology, chemistry and engineering for drug product development. Solid-state NMR analyzes a wide range of drug and wet pharmaceutical materials from small molecule medicines to biological products. The obtained structural information at macroscopic and microscopic scales offer critical knowledge for understanding and optimizing drug delivery, chemical and physical stability, bioavailability, formulation composition, and manufacturing process. This presentation will provide examples to introduce the molecular structure mediated questions in pharmaceutical sciences and elaborate how ssNMR techniques are employed to tackle these analytical challenges.   

Seminar details:

Time:
7:00 – 8:00pm, 3/25/2021 EST
The seminar is free of charge and sponsored by NJACS NMR Topical Group

Link to the webinar (uses Microsoft Teams):

https://njacs.org/nmr-2021-03-25

Register

Please [ register here ] for this meeting

Questions:

Bradley.Falk@bms.com (Chair)
Jon.Williams@rutgers.edu (Co-Chair)

Microsoft Teams meeting

Join on your computer or mobile app

Click here to join the meeting

Or call in (audio only)

+1 908-409-1059,,7161180# United States, Elizabeth

(833) 733-5876,,7161180# United States (Toll-free)

Phone Conference ID: 868 851 55#

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Audio for this meeting can be heard in the Microsoft Teams client. Please check your audio device settings before you join the call. If you see phone numbers above, you can use them to join the meeting’s audio if necessary.

Learn More | Meeting options

2021-03-25

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