The North Jersey ACS NMR Topical Group is pleased to present its April meeting online, Thurs, April 20, 12:00 noon ET, via Microsoft Teams.

Featured Presentation

Seminar details:

Date: Thursday April 20 at 12:00 noon ET

Carrie PartchSpeaker: Carrie Partch
Professor, University of California Santa Cruz
Department of Chemistry and Biochemistry [ ]

Title: “An intrinsically disordered phosphoswitch controls circadian timekeeping in humans”

Flyer: [ NJACS-flyer-Carrie-Partch-APR2023_v1.pdf ]

Our lives are intimately linked to Earth’s 24-hour solar cycle by circadian clocks that coordinate physiology and behavior into rhythms that coincide with the day/night cycle. Recent studies of the genetic basis of morning lark and night owl behavior in humans have identified inherited alleles that alter the intrinsic timing of circadian rhythms. Here, I’ll describe our discovery of the mechanism by which morning lark alleles regulate clock protein dynamics and activity to shorten the human circadian clock by ~4 hours. NMR spectroscopy played a particularly powerful role in this project by identifying how sequential phosphorylation of a multi-serine cluster in the clock protein PERIOD generates feedback inhibition of the major clock kinase, CK1δ, to control clock timing. 

Connection Information

This will be a virtual meeting hosted via Microsoft Teams

The seminar is free of charge. No advance registration is required.

Link to the meeting (uses Microsoft Teams):


Jonathan.OsbornPopp (Chair) (Co-Chair)

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