The North Jersey ACS NMR Topical Group is pleased to present its January meeting online, Fri, January 27, 12:00 noon ET, via Microsoft Teams.  (Note: This meeting was originally listed for Thurs Jan 26) 

Featured Presentation

Christine Jorge

Seminar details:

Date: Friday January 27 at 12:00 noon ET
Speaker: Christine Jorge
Bristol Myers Squibb [ ]

Title: “Analytical Characterization of Macrocyclic Peptidomimetic Compounds by NMR Spectroscopy”
Flyer: [ NMR-2023-01-flyer-v2.pdf ]

In an effort to develop novel therapeutics to complex biological targets, many new drug modalities that extend beyond traditional small molecule drugs have gained popularity within the drug discovery landscape. Amongst these, peptide-based drugs offer an attractive means of inhibiting protein:protein interactions of featureless protein surfaces and constitute ~10% of new drug approvals in the past 2 years. The hybrid features of peptido-mimetic drugs make analytical and structural characterization using standard small molecule or protein techniques difficult, and a robust analytical toolkit is needed. Herein, we describe several NMR based applications to the characterization of conformationally constrained cyclic peptidomimetic compounds including: 1) concentration determination and purity workflows, 2) triaging of well- behaved single conformer compounds by 1D proton spectral screening, 3) qualitative structural characterization for medium throughput analysis and 4) generation of full 3D structural ensembles on well behaved drug leads. These methods have been applied to address numerous questions in the early discovery process. 

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This will be a virtual meeting hosted via Microsoft Teams

The seminar is free of charge. No advance registration is required.

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Jonathan.OsbornPopp (Chair) (Co-Chair)

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