NJ-ACS Mass Spec Discussion Group

The NJ Mass Spectrometry Discussion Group is pleased to announce our December 8, 2021 Meeting — Online!

NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

[raw] Date:…..Wednesday December 8, 2021

Time:…..7:00 PM | (UTC-05:00) Eastern Time (US & Canada)



Join:…..[ below ]

Sponsor:..Waters Corporation





Speaker 1: Dr. Ying Zhang, Pfizer


Streamlining and Accelerating Peptide Multi-Attribute Method (MAM) Analysis with a BioAccord MAM Workflow to Enhance Product Knowledge”


Abstract:  Development of biopharmaceuticals requires a thorough understanding of product quality attributes (PQAs) and impurities to ensure that the product meets desired safety and efficacy profiles. Multi-attribute method (MAM), based on LC-MS peptide mapping technology, enables direct site-specific monitoring of challenging PQAs and allows enhanced product and process understanding. In this presentation, we will demonstrate how we utilize a BioAccord MAM workflow to increase our product knowledge through both PQA monitoring and new peak detection.

Speaker 2: Dr. Jennifer Nguyen, Waters Corporation


Rapid Analysis of Synthetic mRNA Cap Structure Using Ion-Pairing RPLC with MaxPeak™ Premier Columns and the BioAccord LC-MS System


Abstract:  The 5’ cap of mRNA is vital to characterize in vaccine development. Ion-pairing reversed phase liquid-chromatography mass spectrometry (LC-MS) can be used to analyze pre-defined 5’ fragments of synthetic mRNA. However, accurate quantitation can be difficult to achieve due to non-specific binding with the system. Moreover, the choice of ion-pairing system can heavily influence the quality and sensitivity of the mass spectra. We developed a rapid and sensitive LC-MS method applicable to synthetic mRNA capping using MaxPeak™ Premier Columns in combination with the compliance-ready BioAccord LC-MS system. Analysis of 5’ capping of IVT mRNA preparations could be achieved in less than 5-minutes. Linearity was demonstrated to detecting product-related impurities down to less than 0.1% of the target 5’ capped fragment.

Pre-registration is not required.  Just join at the appointed time


NJACS MSDG invites you

to a Webex meeting.

NJ-ACS Mass Spectrometry Discussion Group Virtual Meeting

Wednesday, December 8, 2021

7:00 pm | Eastern Time | 1 hr 15 mins


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Meeting number (access code): 2559 427 5257

Meeting Password: axP5cDbSs22

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Access code: 2559 427 5257

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