Upcoming MSDG Event

April 11, 2023 – MSDG Meeting

The NJ Mass Spectrometry Discussion Group is pleased to announce our April 11 2023 Meeting.

NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date: Tuesday, April 11, 2023

Venue: Somerville Elks Lodge 1068

375 Union Avenue, Bridgewater, NJ 08807

(908) 707-1545

Please register here. It’s free, including dinner, but registration is required.

Masks or no masks are respected and welcomed.

Program

5:30 PM Social time (cash bar / appetizers)
6:15 PM Complimentary Dinner
6:55 PM Welcome and Opening Remarks
7:05 PM Invited Speaker

Speaker 1: Wendy Zhong, PhD, Sr. Principal Scientist, Analytical Research & Development, Merck Research Laboratories, Rahway, NJ, USA

“Label Free Molecular Imaging and Electron-based Dissociation via High Resolution Mass Spectrometry—Applications in Pharmaceutical Industry”

Abstract:

Abstract: With the increased complexity of new and diverse modalities in the pharmaceutical industry, there is a high demand to develop more sensitive and versatile analytical tools. HRMS has become an important analytical technique due to its broad applications in small molecule structure identification, molecular imaging, large biomolecules such as protein and antibody-drug conjugate characterization. In this presentation, I will discuss several unique/innovative approaches we developed and applied to solve challenging problems in drug discovery and development.

• Label free molecular imaging applications in tissues and tablets

Fatty liver disease phenotype is characterized by both an increase in the concentration and synthesis rate of neutral lipids (NL) across the liver. The spatial distribution of multiple lipids classes is poorly characterized in fatty liver disease. A novel method was development to enhance ionization of neutral lipid via Sodium-Doped Gold-Assisted Laser Desorption Ionization. This method can allow investigators to obtain spatial resolution of lipogenic flux by coupling imaging mass spectrometry and isotope tracers. Long-acting injectable (LAI) implants can deliver a drug over several weeks to years, reducing the dosing frequency and improving patient adherence. An innovative approach of using MALDI-MSI to characterize the drug release process from LAI implants was developed. This method provides definitive molecular-level information about the chemical composition as well as the distribution of APIs simultaneously.

• Development of Electron-based dissociation (ExD) to differentiate isomeric amino acids

Isomeric amino acids such as aspartic isoaspartic acid leucine/isoleucine, and valine/norvaline are widely present in peptides and proteins. For example: Leu and Ile count for 16% of all amino acids in proteins. Nva differs from Leu by only one methyl group, and mis-incorporation of Nva is common during the production of recombinant proteins. Conventional CID generates the same m/z value for these isomers and consequently is unable to differentiate isobaric species. Therefore, it poses a challenge to establishing correct peptide and proteins sequences. Electron-activated dissociation (ExD) was developed to differentiate these isomeric amino acid residues in therapeutic peptide and protein.

Speaker 2: Ethan Yang, PhD, Applications Lead, Imaging/MRMS, Bruker Scientific LLC, Billerica, MA USA

“Recent Advances in High Spatial Resolution MALDI Imaging for Metabolomics and Proteomics with the Bruker timsTOF fleX MALDI-2 Platform”

Abstract:

Abstract: Recent innovations in instrumentation in the Bruker MALDI imaging platform—the timsTOF fleX MALDI-2 with microGRID—are now enabling deeper biological investigations in small metabolites and large proteins. Specific examples of metabolic pathways and cancer biology with results as 5 µm spatial resolution are shown.

✎ 2023-05-11

(Past Events)

Nov 1, 2022 – MSDG Meeting

Under Construction

The NJ Mass Spectrometry Discussion Group is pleased to announce our November 2022 Meeting.

NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date: Tuesday, November 1, 2022

Venue: Somerville Elks Lodge 1068

375 Union Avenue, Bridgewater, NJ 08807

(908) 707-1545

Please register here. Free but registration required. Includes dinner.

Masks or no masks are respected and welcomed.

Program

4:30 PM Social time (cash bar / appetizers)
6:00 PM Complimentary Dinner
7:00 PM Invited Speaker

The NJMSDG steering committee is delighted to welcome ASMS’s Archivist / Historian, P. Jane Gale, PhD to present

“Decade by Decade: An Historical Review of Mass Spectrometry and ASMS in the Second Half of the 20th Century“

P. Jane Gale, Ph.D. to present on Tuesday, November 1st 2022

Abstract:

Abstract: Following fifteen years of meeting as part of the American Society for Testing and Materials (ASTM, now ASTM International) a small group of influential mass spectrometrists broke away from the umbrella group to found the American Society for Mass Spectrometry. Whereas in the early days talks at annual get-togethers were dominated by topics related to the oil industry, the newly formed ASMS had a broader focus and included lively discussions of everything from mechanistic studies of molecules in the gas phase to surface science studies of materials important to the electronics industry. The growing Society became the premier US venue in which to present both fundamental research on the technique and applied research into its use in ever-widening fields of study. This talk will follow the Society’s growth and development over the last 70+ years, incorporating into that history the vast array of scientific developments that enabled new areas of application.

We will have a contest (with prizes) for the oldest working mass spectrometer! We’ll include all pictures in a slide show. Please send pictures and provenances/details to ccabral@njacs.org. You must be present to win but, but, but, you can submit any ‘known to you’ MS with proper details. So reach back to those university instruments where you eked out that data for your PhD, etc, . . . love to have your pics and stories . . . but it must still be working – no old unit sitting in storage waiting for someone to figure out how to dispose of it 😊. This will be like ‘baby picture’ time in reverse.

✎ 2022-11-01

(Past Events)

April 12, 2022 – MSDG Meeting

The NJ Mass Spectrometry Discussion Group is pleased to announce our April 12, 2022 Meeting — Online!

NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:.....Tuesday April 12, 2022

Time:.....7:00 PM | (UTC-05:00) Eastern Time (US & Canada)

Via:......Webex

Cost:.....Free

Join:.....[ below ]

Sponsor:..Bruker

Program

Speaker 1: Hanno Steen, PhD, Director of Proteomics and Associate Professor, Department of Pathology, Boston Children’s Hospital and Harvard Medical School, Boston, MA, USA

“Scaling up while scaling down – Sample-sparing High Throughput Proteomics”

Abstract:

Abstract: Since its inception, proteomics was poised to revolutionize clinical diagnostics by providing novel biomarkers. Currently, however, proteomics has not met its own expectations particularly because large population sizes are required for meaningful biomarkers that can account for genetic, environmental and lifestyle variance. A main bottleneck has been the suboptimal throughput. Enabling throughput will allow the robust processing and analysis of statistically meaningful samples numbers, i.e., hundreds to thousands of samples within a reasonable timeframe. Our recent, involvement in several NIAID immunophenotyping studies focused on understanding COVID-19 impact on the immune system, the efficacy of vaccination, and ontogeny in early life with thousands of plasma samples, highlighted the importance of increasing throughput in collecting high quality data while simultaneously decreasing the amount of required starting material. The Steen Lab has developed a high throughput proteomics platform that allows for the robust processing and analysis of such large numbers of plasma samples. These efforts leveraged the methodology and experience of the Steen Lab to process and analyze hundreds of urine samples with the aim of identifying non-invasive biomarker candidates. The presentation will describe method development from the Steen Lab towards i) high throughput proteomics, ii) improved depth of the plasma proteome, and iii) meta-analyses converting many small studies and datasets into a large dataset with statistical relevance. Our platform which incorporates these approaches will enable the analysis of small volumes of large sample numbers which will bring allow us to understand deviations from normal despite natural interpersonal variability, i.e., truly personalized medicine.

Speaker 2: Matt Willets, US Proteomics Applications Manager, Bruker

“Ultra-sensitive 4D Proteomics on the timsTOF SCP mass spectrometer”

Abstract:

Abstract: The timsTOF SCP is the first commercially introduced mass spectrometer for single cell proteomics. The modified front end (orthogonal ion guide) and the brighter ion beam increase the ion transfer up to five times while maintaining instrument high robustness. In this presentation, we will show how the ultra-high sensitivity of the timsTOF Pro can benefit workflows from immunopeptidomics to single cell analysis

Pre-registration is not required. Just join at the appointed time

NJACS MSDG invites you

to a Webex meeting.

NJ-ACS Mass Spectrometry Discussion Group Virtual Meeting

Tuesday, April 12, 2022

7:00 pm | Eastern Time | 1 hr 15 mins

More ways to join:

Join from the meeting link:

https://njacsmsdg.my.webex.com/njacsmsdg.my/j.php?MTID=m1e203489cf1f1889aa56b4f2851a4b60

Join by meeting number:

Meeting number (access code): 2556 896 6928

Meeting Password: 6543212

(also 654321 from phones and video systems)

Join by phone (voice only):

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Access code: 2556 896 6928

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✎ 2022-04-12

(Past Events)

December 8, 2021 – MSDG Meeting

The NJ Mass Spectrometry Discussion Group is pleased to announce our December 8, 2021 Meeting — Online!

NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:.....Wednesday December 8, 2021

Time:.....7:00 PM | (UTC-05:00) Eastern Time (US & Canada)

Via:......Webex

Cost:.....Free

Join:.....[ below ]

Sponsor:..Waters Corporation

Program

Speaker 1: Dr. Ying Zhang, Pfizer

Streamlining and Accelerating Peptide Multi-Attribute Method (MAM) Analysis with a BioAccord MAM Workflow to Enhance Product Knowledge”

Abstract:

Abstract: Development of biopharmaceuticals requires a thorough understanding of product quality attributes (PQAs) and impurities to ensure that the product meets desired safety and efficacy profiles. Multi-attribute method (MAM), based on LC-MS peptide mapping technology, enables direct site-specific monitoring of challenging PQAs and allows enhanced product and process understanding. In this presentation, we will demonstrate how we utilize a BioAccord MAM workflow to increase our product knowledge through both PQA monitoring and new peak detection.

Speaker 2: Dr. Jennifer Nguyen, Waters Corporation

“Rapid Analysis of Synthetic mRNA Cap Structure Using Ion-Pairing RPLC with MaxPeak™ Premier Columns and the BioAccord LC-MS System”

Abstract:

Abstract: The 5’ cap of mRNA is vital to characterize in vaccine development. Ion-pairing reversed phase liquid-chromatography mass spectrometry (LC-MS) can be used to analyze pre-defined 5’ fragments of synthetic mRNA. However, accurate quantitation can be difficult to achieve due to non-specific binding with the system. Moreover, the choice of ion-pairing system can heavily influence the quality and sensitivity of the mass spectra. We developed a rapid and sensitive LC-MS method applicable to synthetic mRNA capping using MaxPeak™ Premier Columns in combination with the compliance-ready BioAccord LC-MS system. Analysis of 5’ capping of IVT mRNA preparations could be achieved in less than 5-minutes. Linearity was demonstrated to detecting product-related impurities down to less than 0.1% of the target 5’ capped fragment.

Pre-registration is not required. Just join at the appointed time

NJACS MSDG invites you

to a Webex meeting.

NJ-ACS Mass Spectrometry Discussion Group Virtual Meeting

Wednesday, December 8, 2021

7:00 pm | Eastern Time | 1 hr 15 mins

More ways to join:

Join from the meeting link:

https://njacsmsdg.my.webex.com/njacsmsdg.my/j.php?MTID=m3734dc989d819feed79b7f62cd39a2a9

Join by meeting number:

Meeting number (access code): 2559 427 5257

Meeting Password: axP5cDbSs22

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Join by phone (voice only):

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Access code: 2559 427 5257

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✎ 2021-12-08

(Past Events)

August 11, 2021 – MSDG Meeting

The NJ Mass Spectrometry Discussion Group is pleased to announce our August 11, 2021 Meeting — Online!

NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:.....Wednesday August 11, 2021

Time:.....7:00 - 8:15 PM

Via:......Webex

Cost:.....Free

Join:.....[ below ]

Sponsor:..SCIEX

Program

Speaker 1: Dr. Andrew Wagner

PhD, Principal Scientist Small Molecule Drug Discovery at Bristol Myers Squibb

“Breaking Throughput Barriers of Mass Spectrometry (MS)-Based Analysis Using Acoustic Ejection Sample Delivery: Impacts in Early Drug Discovery and Beyond”

Abstract:

Abstract: Label-free, MS-based analysis is routinely used throughout drug discovery to help drive important decision-making and enable lead discovery, hit triaging and lead optimization. MS-based methodologies have traditionally relied upon liquid chromatography (LC) or on-line solid phase extraction (SPE) as front-end sample clean-up mechanisms. These approaches have slow cycle times (> 10 seconds/sample) that often aren’t amenable to high throughput screening assays conducted in 384- or 1536-well plates. Acoustic ejection mass spectrometry is a recently developed high-throughput MS approach that combines acoustic droplet ejection (ADE) with an open-port interface (OPI) to enable direct sample introduction from plates into the mass spectrometer for analysis. Using the acoustic ejection mass spectrometer system, we have demonstrated analytical throughput speeds as fast as 1 second-per-sample for multiple screening assays. This remarkable improvement in MS cycle time, approaching that of optical plate readers, has resulted in increased capacity and faster turn-around-time for reading many critical early drug discovery studies such as liability assessment and activity-based screens, and has the potential to impact many other areas within drug discovery.

Speaker 2: Dr. Jose Castro-Perez

Senior Director Accurate Mass Product Management at SCIEX

“New novel developments in high resolution mass spectrometry to address lower levels of detection and improved characterization of analytes”

Abstract:

Abstract: High resolution mass spectrometry has continued to grow as new application areas are constantly emerging. Here, we will present and discuss new developments which addresses both sensitivity and structural characterization needs for a variety of application areas for both small and large molecules in Life Sciences Multi-Omics and also in Drug Discovery..

Pre-registration is not required. Just join at the appointed time

NJACS MSDG invites you

to a Webex meeting.

NJ-ACS Mass Spectrometry Discussion Group Virtual Meeting

Wednesday, August 11, 2021

7:00 pm | Eastern Time | 1 hr 15 mins

More ways to join:

Join from the meeting link:

https://njacsmsdg.my.webex.com/njacsmsdg.my/j.php?MTID=m4d5315d73fb5ba10bf95e9ab1be241b6

Join by meeting number:

Meeting number (access code): 182 511 6738

Meeting Password: WRn5e29HjnP

(97653294 from phones and video systems)

Join by phone (voice only):

+1-510-338-9438 (USA Toll)

Access code: 182 511 6738

Or by a single tap on a mobile phone (voice only):

+1-510-338-9438,,1825116738 (USA Toll)

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✎ 2021-08-11

(Past Events)

July 21, 2021 – MSDG Meeting

The NJ Mass Spectrometry Discussion Group is pleased to announce our July 21, 2021 Meeting — Online!

NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:.....Wednesday July 21, 2021

Time:.....6:30 - 7:45 PM

Via:......Webex

Cost:.....Free

Join:.....[ below ]

Sponsor:..Agilent

Program

Speaker 1: Dr. John Schiel

PhD, NIST Biomolecular Measurement Division

“Multi-Attribute Mass Spectrometry as a Multi-Modality Technology”

Abstract:

Abstract: Characterization of mAbs has evolved during the past 30 years to include a toolbox of measurements to elucidate identity, quality, and stability. Molecular complexity is magnified with gene therapies, as is the need to pursue adaptation of high-resolution analytical measurement approaches to further the understanding and development of these novel modalities. This talk will describe the principles of the multi-attribute mass spectrometry method (MAM) as applied to mAbs and its evolution toward identification and control of viral vector quality attributes.

About Dr. Schiel:

Bio: Dr. Schiel received his BS (2004) and Ph.D. (2009) in chemistry from the University of Nebraska-Lincoln, and is currently a research chemist in the NIST Biomolecular Measurement Division. Dr. Schiel coordinates the development of Reference Materials that support the biomanufacturing industry, including the recombinant IgG1κ NIST monoclonal antibody Reference Material 8671 (NISTmAB). He also leads an analytical research team developing innovative approaches toward production/characterization of next generation biotherapeutics (e.g. viral vectors, cell therapy products, and vaccines) and de-risking of innovative technologies for lifecycle appropriate implementation and regulatory assimilation. He is an author of over 30 publications, an editor of the ACS book series “State-of-the-Art and Emerging Technologies for Therapeutic Monoclonal Antibody Characterization”, and recipient of numerous Awards including the Arthur S. Flemming Award, Department of Commerce Gold Medal, ACS Division of Analytical Chemistry Fellowship, Bioanalysis Young Investigator Award, and UNL Early Achiever Award.

Speaker 2: Peter Rye

Application Scientist, Agilent

“Characterization and quantification of synthetic oligonucleotides using HRAM and QQQ”

Abstract:

Abstract: Mass spectrometry plays a vital role in the measurement and characterization of synthetic DNA and RNA oligonucleotides (oligos), which are used widely in molecular biology and in the development of therapeutics. This webinar will highlight (1) the quantitative analysis of oligos, both by QQQ and HRAM technologies, to achieve the best combination of sensitivity and speed, (2) impurities determinations using HRAM, multiple analysis techniques, and purpose-built software, and (3) high-throughput methods that enable the acquisition, analysis, and purity review of over 5,000 samples a day. Join us to push the speed, sensitivity, and dynamic range of oligo measurements to new heights.

Pre-registration is not required. Just join at the appointed time

NJACS MSDG invites you

to a Webex meeting.

NJ-ACS Mass Spectrometry Discussion Group Virtual Meeting

Wednesday, July 21, 2021

6:30 pm | Eastern Time | 1 hr 15 mins

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Join from the meeting link:

https://njacsmsdg.my.webex.com/njacsmsdg.my/j.php?MTID=mfb241ec2bcd360aa25aaa41360c41b12

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Meeting number (access code): 182 221 1293

Meeting Password: nFAMNdAX834

(63266329 from phones and video systems)

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+1-510-338-9438 (USA Toll)

Access code: 182 221 1293

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✎ 2021-07-21

(Past Events)

May 12, 2021 – MSDG Meeting

The NJ Mass Spectrometry Discussion Group is pleased to announce our May 12, 2021 Meeting — Online!

NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:.....Wednesday May 12, 2021

Time:.....7:00 - 8:15 PM

Via:......Webex

Cost:.....Free

Join:.....[ below ]

Sponsor:..Bruker

Program

Speaker 1: Dr. Matt Willetts

PhD, Bruker Scientific LLC, runs the Proteomics Applications for the Eastern US and is based in Billerica MA. Matt received his Ph.D. from Sheffield Hallam University in the UK

“timsTOF: Stop Compromising & have it all! – Throughput, Sensitivity, PTMs, Imaging, and Robustness”

Abstract:

Abstract: Trapped Ion Mobility on the timsTOF enables you to find more proteins, faster and with less sample than ever before with enhanced DDA and new DIA approaches using parallel accumulation and followed up with serial fragmentation (PASEF). Throughput is now primed for clinical research cohorts. New SpatialOMx workflows on the timsTOF fleX mean you can image molecules on a tissue section and run a deep coverage LC-MS/MS analysis from the same sample, and on the same instrument.

Speaker 2: Ying Ge, PhD

Professor Department of Cell and Regenerative Biology, Department of Chemistry, and Human Proteomics Program, University of Wisconsin-Madison

“New Strategies in Top-down Proteomics for Precision Medicine”

Abstract:

Abstract: Transformative insights from a holistic approach at the systems level have great potential to elucidate disease mechanisms and to develop new therapeutic treatments for precision medicine. Proteomics is essential for deciphering how proteins interact as a system and for understanding the functions of cellular systems in human diseases. However, the unique characteristics of the human proteome, which include the large dynamic range of protein expression and the extreme complexity resulting from a plethora of post-translational modifications (PTMs) and sequence variations, make such analyses difficult. The top-down mass spectrometry (MS)-based proteomics, which is based on analysis of intact proteins, is arguably the most powerful method to comprehensively characterize proteoforms that arise from genetic variations, alternative splicing, and PTMs. My group has made significant advances in top-down MS for analysis of large intact proteins purified from complex biological samples including cell and tissue lysate as well as body fluids. Recently, we are employing a multi-pronged approach to address the challenges in top-down proteomics in a comprehensive manner by developing new MS-compatible surfactants for protein solubilization, novel materials and new strategies for multi-dimensional chromatography separation of proteins, novel nanomaterials for enrichment of low-abundance proteins, as well as a new comprehensive user-friendly software package, MASH Explorer for top-down proteomics. In this talk I will present our recent technology developments in top-down high-resolution mass spectrometry-based proteomics as well as its application to pharmaceutical research, cardiac systems biology and precision medicine.

Pre-registration is not required. Just join at the appointed time

NJACS MSDG invites you

to a Webex meeting.

NJ-ACS Mass Spectrometry Discussion Group Virtual Meeting

Wednesday, May 12, 2021

7:00 pm | Eastern Time | 1 hr 15 mins

More ways to join:

Join from the meeting link:

https://njacsmsdg.my.webex.com/njacsmsdg.my/j.php?MTID=m5c4f9295cad8da91881d37e3bce54bf6

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Meeting number (access code): 182 595 8225

Meeting Password: egMHp2PMK85

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Access code: 182 595 8225

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✎ 2021-05-12

(Past Events)

Apr 28, 2021 – MSDG Meeting

The NJ Mass Spectrometry Discussion Group is pleased to announce our April 2021 Meeting — Online!

NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:.....Wednesday April 28, 2021

Time:.....7:00 - 8:15 PM

Via:......Webex

Cost:.....Free

Join:.....[ below ]

Sponsor:..MOBILion Systems Inc.

Program

Speaker 1: Daniel DeBord

PhD, Director of R&D MOBILion Systems Inc.

“Is Structures for Lossless Ion Manipulation (SLIM) a One Trick Pony or a One Stop Shop for Ion Mobility-Mass Spectrometry Analysis?”

Abstract:

Abstract: Since its introduction in 2014, SLIM has been used to demonstrate unprecedented levels of ion mobility resolution and the potential impact of this resolution on both the depth and throughput of analysis.Integration has focused on the combination of high-resolution ion mobility (HRIM) with high resolution mass spectrometry (HRMS) in the form of time of flight instrumentation. This system configuration provides broad spectrum acquisition along with fast analysis times, making it most suitable for discovery or characterization analyses where the goal is to see “everything” with as much specificity as possible.

Researchers at MOBILion have been working to evolve SLIM functionality to also support targeted applications where the goal is instead to focus on a certain number of analytes, but to be able to detect them as accurately and sensitively as possible, even within complex biological matrices. This presentation will provide an overview of these various designs of the SLIM and show how this platform technology can be tailored to enhance the performance of all types of mass spectrometric detection.

Speaker 2: Jeffrey Agar

PhD, Associate Professor of Chemistry and Pharmaceutical Science at Northeastern University's Barnett Institute

“Top-down- and ion mobility MS-enabled drug discovery for ALS”

Abstract:

Abstract: We have employed top-down MS to discover ALS-related structural changes to SOD1, an ALS-associated protein. Topics will include custom-made antibodies to purify SOD1 (which can cause ALS) from ALS patients; using ultrahigh resolution MS to determine the sites of PTMs and how these modifications effect SOD1 higher-order structure; determining which modifications are disease-relevant using neurotoxicology assays; and the development of a novel, privileged chemistry using modified cyclic disulfides, for preventing oxidative PTMs and stabilizing proteins.

Pre-registration is not required. Just join at the appointed time

NJACS MSDG invites you

to a Webex meeting.

NJ-ACS Mass Spectrometry Discussion Group Virtual Meeting -- Hosted by MOBILion Systems Inc.

Wednesday, April 28, 2021

7:00 pm | Eastern Time | 1 hr 15 mins

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Join from the meeting link:

https://njacsmsdg.my.webex.com/njacsmsdg.my/j.php?MTID=m6259274ea15ade2e5e42aac0aeab1778

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Meeting number (access code): 182 837 8684

Meeting Password: aFHN2U2jgx5

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Access code: 182 604 4539

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✎ 2021-04-28

(Past Events)

Mar 23, 2021 – MSDG Meeting

The NJ Mass Spectrometry Discussion Group is pleased to announce our March 2021 Meeting — Online!

NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:.....Tuesday March 23, 2021

Time:.....7:00 - 8:15 PM

Via:......Webex

Cost:.....Free

Join:.....[ below ]

Sponsor:..Shimadzu

Shimadzu Scientific Instruments cordially invites you to join us for an online talk on improving throughput in your laboratory.

Program

Speakers: Stephen Kurzyniec

Pharma/Biopharma Business Development Manager, Shimadzu Scientific Instruments

“Mass Spec Approaches to Supporting Biologic Development”

Abstract:

Abstract: Monoclonal antibodies (mAbs) have become the most common modality for Biopharma therapeutic research programs. Years of research and development are required to identify the best candidate to move forward into clinical trials. Along the way, many analytical assays are used to screen, characterize and quantify these biomolecules. Traditionally, immunoassays such as ELISA (enzyme-linked Immunosorbent assay) have been the preferred analytical method, but more techniques have been stepping up to the challenge. Since the unique critical reagents required for ELISA can take months to generate, analytical techniques that take less method development time can have an “early-adoption” advantage that speeds up critical decision-making. Among them, LC-MS is the most appealing due to the accuracy, sensitivity, and specificity achieved by it.

In this presentation, we will discuss workflows to aid in the development, characterization and quantitation monoclonal antibodies. Shimadzu’s Cell Culture Media analysis provides bioprocess development scientists a 125-component snapshot in a single 17-minute LCMSMS method. Coupled with Protein Metrics Byos software, Shimadzu’s 9030 LCMS-QToF can provide an in-depth assessment of a mAb’s overall composition. Finally, Shimadzu’s nSMOL immunocapture kit for the quantitation of traditional mAbs, biosimilars, and hybrids by LC-MS/MS. Along with the nSMOL kit, the Ultra Fast scanning (30000 u/sec) and extreme sensitivity of the Shimadzu LCMS-8060 system allows for the detection of many CDR peptides from a single mAb or even for multiplexed samples in a single analytical run. The minimal method development time of nSMOL coupled with mass spectrometry can be a game-changer for mAb analysis in a high-throughput laboratory.

Pre-registration is not required. Just join at the appointed time

NJACS MSDG invites you

to a Webex meeting.

“Mass Spec Approaches to Supporting Biologic Development”

Host: NJACS MSDG

Tuesday, March 23, 2021

7:00 pm | Eastern Time | 1 hr 15 mins

Meeting number: 182 604 4539

Password: KSem85aCfg8

(57368522 from phones and video systems)

Join by phone +1-510-338-9438 (USA Toll)

Access code: 182 604 4539

Need help? Go to https://help.webex.com

✎ 2021-03-23

(Past Events)

Sep 22, 2020 – MSDG Meeting

The NJ Mass Spectrometry Discussion Group is pleased to announce our September 2020 Meeting — Online!

NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:.....Tuesday September 22, 2020

Time:.....7:00 PM

Via:......Webex

Cost:.....Free

Join:.....[ below ]

Sponsor:..Novatia

Program

Speakers: Robert Schuster and Kevin McCarl

Novatia, LLC Newtown, PA

“Automated deconvolution and analysis of intact biomolecule MS data: From Antibody drug conjugates to oligonucleotides”

Abstract:

Abstract: ProMass is the only fully automated mass spectrum deconvolution software package with versatile integration into ThermoFisher, Waters and SCIEX instrument operating platforms and a wide array of applications. ProMass can be used to analyze the mass spectra of oligonucleotides, proteins, monoclonal antibodies (mAbs), antibody drug conjugates (ADCs), small molecules and a variety of polymeric materials. This webinar will focus on the application of ProMass to characterize antibody drug conjugates and oligonucleotides. One study is the application of ProMass in conjunction with a Waters qTOF mass spectrometer to characterize lysine- and cysteine- antibody drug conjugate standards produced in-house, including automated DAR calculation. In another study, ProMass HR was partnered with a Thermo Orbitrap to isotopically resolve oligonucleotide standards and a Thermo LTQ XL to develop a high throughput platform for rapid oligonucleotide quality control analysis.

Bio for: Robert Schuster, Ph.D.

Bio: Robert Schuster holds a B.S. in Biochemistry from Oakland University (2008), an M.S. in Chemistry from Tufts University (2011) and a Ph.D. in Medicinal Chemistry from Purdue University (2016). During his time at Purdue University, Rob worked with Laurie L. Parker and Jean-Christophe Rochet in the study of intracellular tyrosine kinase activation in Parkinson’s disease and Chronic Myeloid Leukemia, using exogenous peptide-based substrates and mass spectrometry (MS) quantitation. This work resulted in a patent on the development of degradation resistant peptide substrates to measure tyrosine kinase activation. As a Senior Research Fellow (Postdoctoral research associate) with Jing Zhang, at the University of Washington School of Medicine, he worked on protein biomarker identification, and the development of MS-based quantitative assays to analyze total protein and PTMs in blood and cerebrospinal fluid of patients diagnosed with Parkinson’s disease. Rob developed chemical derivatization methods to improve the sensitivity of assays measuring abundantly low peptides. Rob joined Novatia as a Senior Scientist in April 2018.

Bio for: Kevin McCarl, B.S.

Bio: Kevin received his B.S. in chemistry from the University of Pittsburgh (2016), where he did research under the direction of Dr. Stephen Weber. The bulk of Kevin’s research involved investigating the relationship between column temperature, mobile phase composition, and solute retention using HPLC and various stationary phases. Also during his time at Pitt, he designed and implemented a group research project which utilized GC-MS to determine the relative nicotine and carcinogen content in E-cigarette juices. Kevin joined Novatia in October 2016 as an Associate Research Scientist to provide and improve Novatia’s LC-MS platform services for biomolecules. He was was promoted to Research Scientist in early 2018 and has since expanded his analysis efforts. He also maintains the Novatia website and manages the company’s marketing efforts.

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NJACS MSDG invites you

to a Webex meeting.
“Automated deconvolution and analysis of intact biomolecule MS data: From Antibody drug conjugates to oligonucleotides”
Host: NJACS MSDG

Tuesday, September 22, 2020

7:00 pm | Eastern Time | 1 hr 15 mins

Meeting number (access code): 142 133 8594 
Meeting password: JXqpjdAD697 (59775323 from phones and video systems).....
Need help? Go to https://help.webex.com

✎ 2020-09-22

Photos From 2012 Events

Dr. Ron Kong, chair of NJACS-MSDG, provided the opening remarks and the highlights for 2012 NJACS-MSDG.: Dr. Ron Kong, chair of NJACS-MSDG, provided the opening remarks and the highlights for 2012 NJACS-MSDG.
Back: Robert Iannucci, Nick Molinaro, Ron Kong, Fangbiao Li, Patrick Bennett; Front: Min Meng, Petia Shipkova, Jerry Pappas: Back: Robert Iannucci, Nick Molinaro, Ron Kong, Fangbiao Li, Patrick Bennett; Front: Min Meng, Petia Shipkova, Jerry Pappas
Dr. Ron Kong, Chair of NJACS-MSDG, gave the opening remarks.: Dr. Ron Kong, Chair of NJACS-MSDG, gave the opening remarks.
2012 NJACS-MSDG Student Travel Award winner, Freneil Jariwala (left), with Ron Kong.: 2012 NJACS-MSDG Student Travel Award winner, Freneil Jariwala (left), with Ron Kong.
Dr. Ignatius Kass, Waters Technologies Corporation, presenting at NJACS-MSDG.: Dr. Ignatius Kass, Waters Technologies Corporation, presenting at NJACS-MSDG.
Dr. Thomas P. Roddy, Merck & Co., Inc., presenting at NJACS-MSDG.: Dr. Thomas P. Roddy, Merck & Co., Inc., presenting at NJACS-MSDG.
Front: Ignatius Kass, Thomas P. Roddy, John Venesky; Back: Jonathan Ho, Brad I. Coopersmith, Robert Iannucci.: Front: Ignatius Kass, Thomas P. Roddy, John Venesky; Back: Jonathan Ho, Brad I. Coopersmith, Robert Iannucci.
Ron Kong, Chair of NJACS-MSDG, welcomed attendees: Ron Kong, Chair of NJACS-MSDG, welcomed attendees
Amber Flynn Charlebois, NJACS section chair, gave opening remarks: Amber Flynn Charlebois, NJACS section chair, gave opening remarks
2012 NJACS-MSDG Distinguished Service Award Winner, Ed Kerns, with Safet Palamar (left) and Ron Kong (right).: 2012 NJACS-MSDG Distinguished Service Award Winner, Ed Kerns, with Safet Palamar (left) and Ron Kong (right).
2012 NJACS-MSDG Early Career Award Winner, Ileana Cristea, with Safet Palamar (left) and Ron Kong (right): 2012 NJACS-MSDG Early Career Award Winner, Ileana Cristea, with Safet Palamar (left) and Ron Kong (right)
2012 NJACS-MSDG Achievement Award Winner, Steven Gross, with Safet Palamar (left) and Ron Kong (right): 2012 NJACS-MSDG Achievement Award Winner, Steven Gross, with Safet Palamar (left) and Ron Kong (right)
Speakers with the Board of 2012 NJ-ACS MSDG.: Speakers with the Board of 2012 NJ-ACS MSDG.

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