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Targeting Heterodimeric G Protein-coupled Receptors as an added Dimension in Drug Design

Philip Portoghese, University of Minnesota

A major technical program for MARM 2006 centers on medicinal chemistry. As part of this program, a full-day symposium in honor of the Alfred Burger Award in Medicinal Chemistry will be held, featuring past award recipients and the rising stars in medicinal chemistry. MARM 2006 is honored that the keynote lecture in this symposium will be presented by the Distinguished Professor Philip Portoghese from the University of Minnesota. Professor Portoghese is internationally well known for excellence in medicinal chemistry and has received numerous awards, including the Oak and the Tulip Medal (European Federation of Medicinal Chemistry), Edward E. Smissman-Bristol-Myers-Squibb Award (ACS Division of Medicinal Chemistry), Nathan B. Eddy Award for Excellence in Drug Abuse Research (NAS-National Research Council), Research Achievement Award in Medicinal Chemistry (American Association of Pharmaceutical Scientists), and the Alfred Burger Award in 2000. His research has made positive contributions to understanding opioids and opioid antagonists, the conformational and configurational analysis of biologically active compounds, and the design and synthesis of affinity labels as receptor probes. His lecture at MARM will focus on recent results from this research group on heterodimeric G protein-coupled receptors in medicinal chemistry. (February 29, 2006)


Capillary Electrophoresis of Cells, Single Fly Heads and Populations of Flies: Towards Understanding Behavior, Addiction and Drugs of Abuse

Andrew G Ewing, Penn State University

A major technical area for MARM 2006 is analytical chemistry. As part of this program, a symposium on the principles and emerging applications of capillary electrophoresis (CE) will be held. MARM 2006 is honored that the keynote lecture in this symposium will be presented by Andrew G. Ewing, J. Lloyd Huck Chair and Professor of Chemistry and Neural and Behavioral Sciences at Penn State University. Professor Ewing is internationally known for excellence in applying numerous analytical techniques to the study of chemistry in and around neuronal micro- and even nano-environments to further the understanding of single-cell neurochemistry and neurophysiology. Professor Ewing has received numerous awards and distinctions, including being named a Guggenheim Fellow (1999), and an AAAS Fellow (2004). He has also received the Benedetti-Pichler Award (2000), and The Frederick Conference Award for Outstanding Achievements in the Field of Capillary Electrophoresis (1999). His lecture at MARM will focus on recent results from his research group on the determination of neurotransmitters in and around single cells, in fly head homogenates and in single fly heads by CE, and how these data can be used to aid our understanding of how the brain functions. (February 28, 2006)


Catalytic Motors and Pumps

MARM 2006 features an in depth technical program in materials science and nanotechnology, headlined by Dr. Thomas Mallouk, director of Penn State University's Center for Nanoscale Science and the DuPont Professor of Materials Chemistry and Physics. Dr. Mallouk will be presenting an exciting plenary lecture on nanoscale motors and pumps. He is well known for his design and application of nanomaterials to several areas of science and society. Dr. Mallouk has applied his creativity to thinking small, using DNA to aid in the assembly of inorganic sheets, rods, and tubes, using combinatorial techniques to discover new fuel cell catalysts, using nanocrystalline semiconductors for artificial photosynthesis, and using chemical "delivery vehicles" for transport of nanoparticles in the remediation of polluted soils. MARM 2006 is honored to have Dr. Mallouk present the Tuesday evening plenary lecture on his collaborative work with Dr. Ayusman Sen and their students on catalytic nanomotors. This lecture will feature amazing videos of nanometer size rods and gears that use hydrogen peroxide to fuel their motion. Anyone interested in how nanoscale chemistry might ultimately change our lives will be happy they attended this thought-stimulating presentation.. (February 23, 2006)


A Retrospective View of Drug Discovery

The 2006 ACS Middle Atlantic Regional Meeting (MARM) is honored to have Dr. Paul Anderson, the 2006 Priestly Medalist and 1997 president of the ACS, presenting a plenary lecture. Dr. Anderson is a distinguished chemist, with nearly 40 years in the pharmaceutical industry, contributing to the discovery of numerous pharmaceutically important compounds, including the HIV drugs Crixivan and Sustiva, the cholesterol lowering drug Zocor, and glaucoma treatment Trusopt. Along with being a leader at Merck, Dupont Pharmaceuticals, and Bristol-Myers Squibb, he has also played a role on scientific advisory boards at smaller pharmaceutical companies, such as Acadia and Achillion. His achievements and service to chemistry have been additionally recognized with many honors and awards; the 2003 National Academy of Sciences Award for Chemistry in Service to Society, the 2002 Perkin Medal, and the 1995 E.B. Hershberg Award to name a few. (March, 2006)


Single Molecule Spectroscopy for Early Diagnosis of Disease

MARM 2006 is honored to have Professor Edward S. Yeung from Iowa State University presenting a lecture as one of the invited plenary speakers. His research, which focuses on the identification, development, evaluation, and application of new measurement concepts, has led to the discovery of new analytical techniques in nonlinear spectroscopy, laser-based detectors, capillary electrophoresis, trace gas monitoring, single-cell and single-molecule analysis, DNA sequencing, and data treatment procedures in chemical measurements. His contributions to chemistry have been recognized by numerous awards, including the ACS Division of Analytical Chemistry Award in Chemical Instrumentation and the Pittsburgh Analytical Chemistry Award. Reaching the ultimate level in microscale spectroscopy, Dr. Yeung's presentation will detail how single molecules can be detected using a novel laser-imaging system. The method provides the ability to look at the chemical constituents within a single human cell, which has important applications to the early diagnosis of diseases. (February, 2006)


Chocolate - Food of the Gods

MARM 2006 promises to be an enjoyable and i n for mative meeting with Dr. Howard and Sally Peters presenting an invited plenary lecture during the Sunday science education day. Dr. Peters has devoted himself to the advancement of chemistry in our world through numerous years of service in ACS governance and as a chemical attorney. An appropriate presentation for a chemistry meeting in "Chocolate Town" - the Peters will provide insight into the history of chocolate from the Mayan and Aztec cultures to the present, the chemistry and biochemistry of theobroma cocoa, and the currently circulating urban legends about chocolate. Over the years, Dr. Peters has presented this talk and others about the history of chemistry as part of his efforts to get more people excited about chemistry and to inform current chemists of how chemistry relates to everyone's life. (January, 2006)







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Last Modified: 03-Mar-2006
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