North Jersey Section
American Chemical Society

Apr 29, 2021 – NMR Topical Group Meeting

The North Jersey ACS NMR Topical Group is pleased to present its April meeting online, Thurs, April 29, 2021, 7:00 pm 


Featured Presentation

Seminar details:

Speaker: Ivan V. Sergeyev, Bristol Myers Squibb

Title: “Dynamic Nuclear Polarization: From Niche Technique to Essential Tool”

Abstract

NMR as a whole, but especially solid-state NMR, can be classed as a “signal-limited” technique – with limited sample volumes, compromises must be made between signal-to-noise ratio and experimental acquisition times. In recent years, a sensitivity revolution has enabled orders-of-magnitude signal enhancements, up to a theoretical maximum of 660- fold, via the Dynamic Nuclear Polarization (DNP) technique. In enabling the gradual easing of the aforementioned compromises, DNP-enhanced SSNMR has enabled studies of systems not previously amenable to solid-state NMR, including whole viruses, amyloid fibrils, membrane proteins, and complex multi-component materials. Yet, the “there is no such thing as a free lunch” mantra also applies — DNP-NMR is not without its pitfalls, generally requiring specialized hardware and modifications to the sample that can impact spectral resolution. Extensive efforts have gone into mitigating these pitfalls and maximizing the sensitivity gains available, especially as the field moves to ever higher magnetic fields. Recent investigations of previously under-explored facets of the technique, for instance direct enhancement of nuclei other than 1H, hint that we have only scratched the surface in terms of the capabilities and potential of DNP. In this talk, I will present:
  • An overview of the technology and mechanisms behind DNP, including recent advances at high magnetic field and low microwave power
  • A brief practical discussion of the state-of-the-art in sample preparation for various DNP applications
  • Recent work in 19F-DNP, with potential implications for the field as a whole
  • Perspectives for the future: combining DNP, ultrafast magic angle spinning (MAS), and selective excitation to revolutionize sensitivity and resolution

Time:
7:00 – 8:00pm, 4/29/2021 EST
The seminar is free of charge and sponsored by NJACS NMR Topical Group

Link to the webinar (uses Microsoft Teams):

https://njacs.org/nmr-2021-04-29

Register

Please [ register here ] for this meeting

Questions:

Bradley.Falk@bms.com (Chair)
Jon.Williams@rutgers.edu (Co-Chair)

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