North Jersey Section
American Chemical Society

Mar 24, 2022 – NMR Topical Group Meeting

The North Jersey ACS NMR Topical Group is pleased to present its March meeting online, Thurs, March 24, 7:00 pm 

Featured Presentation

Seminar details:

Date: Thursday March 24th 7:00 pm ET

Speaker: Prof. Galia Debelouchina
Department of Chemistry & Biochemistry
University of California, San Diego

Title: “NMR-Based Tools for Structural Biology of Complex Systems: From Gels to Cells”

Flyer: [ 2022-03-24-NMR-flyer.pdf ]


Recent advances in structural biology have dramatically expanded the scope of proteins and assemblies that are now amenable to structural analysis. Yet, many biological systems display dynamics and undergo transformations that have been difficult to capture experimentally, especially in complex or native settings. In this context, my group has been developing NMR-based methodologies to describe such challenging systems and to pave the way to the next exciting structural biology frontier, the cellular environment. Here, I will present our progress on two fronts: 1) Development of NMR methodologies to describe the molecular basis of protein phase transitions from the liquid to the gel and solid states. In particular, I will focus on the transitions displayed by heterochromatin protein 1α (HP1α), a key player in gene regulation and chromatin organization. 2) Development of sensitivity-enhanced NMR approaches suitable for the cellular environment. Our work is based on a methodology called dynamic nuclear polarization (DNP) which can transfer polarization from electron to nuclear spins and thus increase nuclear signals by several orders of magnitude. For this purpose, we develop small molecule DNP polarization agents that contain unpaired electron spins and that can be targeted selectively to a protein of interest. These agents have allowed us to obtain NMR structural data of tiny amounts of proteins (1-5 μg) and to study the  polarization transfer mechanisms in targeted DNP experiments.

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This will be a virtual meeting hosted via Microsoft Teams.

The seminar is free of charge. No advance registration is required.

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