The North Jersey ACS NMR Topical Group
Meeting cancelled due to coronavirus outbreak.
is pleased to presents its March meeting at Rutgers, Wednesday, March 25, 2020, from 6:00 to 8:00 pm [ register ]
Speaker: Dr. Robin A. de Graaf, Professor of Radiology and Biomedical Imaging, Yale University
Title: “Deuterium Metabolic Imaging (DMI), a novel MR-based method to map metabolism in 3D”
Non-invasive imaging of metabolic pathways in neurological disease has been a long-standing goal to monitor disease progression or therapy efficacy. Positron emission tomography (PET) in combination with 2-18F-fluoro-2-deoxy-D-glucose (FDG) is currently the only clinically viable metabolic imaging method. However, the high uptake of FDG by normal brain drastically reduces the image contrast and the usefulness of FDG-PET in studying neurological disease. MR-based methods (1H, 13C, hyperpolarized 13C MRS) are promising but have failed to reach clinical significance due to technical complexity and lack of robustness and/or sensitivity. Deuterium metabolic imaging (DMI) is a novel MR-based method that uses the favorable MR characteristics of deuterium to map metabolism in vivo in 3D. The low intrinsic sensitivity of 2H NMR is offset by favorable T1 and T2 relaxation times, a large nuclear spin and a sparse NMR spectrum devoid of strong water and lipid signals. By combining 2H NMR with deuterated glucose administration (oral or intravenous), MR spectroscopic imaging and signal quantification through spectral fitting we were able to generate deuterium metabolic images of brain, brain tumor and liver metabolism in vivo. Our first-in-human DMI maps of glucose metabolism in healthy brain and in patients with high grade brain tumors illustrate that DMI has the potential to become a robust and widely applicable brain imaging method with strong clinical utility.
6:00 pm Dinner + Retirement cake for George Anastasi
6:45 pm Raffle
7:00 pm Seminar (No charge for seminar only)
Dinner Cost (pay at the door):
$10 employed / $5 students, postdoc, retired, unemployed. No charge for seminar only.
Department of Chemistry and Chemical Biology, CCB
123 Bevier Rd
Piscataway, NJ 08854 [ Driving Directions to the new CCB Building ]
Parking: Parking will be available in LOT 54 (described in Driving Directions)
Important: Please register your car in advance with Rutgers Parking Department at:
Please register online [ here ] or via e-mail to