North Jersey Section
American Chemical Society

Mar 25, 2020 – NMR Topical Group Meeting CANCELLED


Meeting cancelled due to coronavirus outbreak.



The North Jersey ACS NMR Topical Group is pleased to presents its March meeting at Rutgers, Wednesday, March 25, 2020, from 6:00 to 8:00 pm  [ register ]

Featured PresentationRobin A de Graff

Speaker: Dr. Robin A. de Graaf, Professor of Radiology and Biomedical Imaging, Yale University

Title: “Deuterium Metabolic Imaging (DMI), a novel MR-based method to map metabolism in 3D”

Abstract

Non-invasive imaging of metabolic pathways in neurological disease has been a long-standing goal to monitor disease progression or therapy efficacy. Positron emission tomography (PET) in combination with 2-18F-fluoro-2-deoxy-D-glucose (FDG) is currently the only clinically viable metabolic imaging method. However, the high uptake of FDG by normal brain drastically reduces the image contrast and the usefulness of FDG-PET in studying neurological disease. MR-based methods (1H, 13C, hyperpolarized 13C MRS) are promising but have failed to reach clinical significance due to technical complexity and lack of robustness and/or sensitivity. Deuterium metabolic imaging (DMI) is a novel MR-based method that uses the favorable MR characteristics of deuterium to map metabolism in vivo in 3D. The low intrinsic sensitivity of 2H NMR is offset by favorable T1 and T2 relaxation times, a large nuclear spin and a sparse NMR spectrum devoid of strong water and lipid signals. By combining 2H NMR with deuterated glucose administration (oral or intravenous), MR spectroscopic imaging and signal quantification through spectral fitting we were able to generate deuterium metabolic images of brain, brain tumor and liver metabolism in vivo. Our first-in-human DMI maps of glucose metabolism in healthy brain and in patients with high grade brain tumors illustrate that DMI has the potential to become a robust and widely applicable brain imaging method with strong clinical utility

Program

6:00 pm Dinner + Retirement cake for George Anastasi
6:45 pm Raffle
7:00 pm Seminar (No charge for seminar only)

Dinner Cost  (pay at the door):

$10 employed / $5 students, postdoc, retired, unemployed. No charge for seminar only.

Meeting Venue

Rutgers University
Department of Chemistry and Chemical Biology, CCB
Room 1203
123 Bevier Rd
Piscataway, NJ 08854   [ Driving Directions to the new CCB Building ]

Parking: Parking will be available in LOT 54 (described in Driving Directions)

Important: Please register your car in advance with Rutgers Parking Department at:
https://rudots.nupark.com/events/Events/Register/afda8f8d-d782-4f00-942b-58eef60339de

Questions:

Justyna.Sikorska@merck.com (Chair)
Bradley.Falk@bms.com (Co-Chair)

Register:

Please register online [ here ] or via e-mail to
Justyna.Sikorska@merck.com (Chair)
Bradley.Falk@bms.com (Co-Chair)

Top