The North Jersey ACS NMR Topical Group is pleased to presents its March meeting at Princeton, Wednesday, January 22, 2020 [ register ]
Speaker: Dr. Bradley Falk, Bristol-Myers Squibb
Title: “Development of a 1H solution NMR platform for characterization, screening, and development of therapeutic proteins and peptides”
Simple 1H NMR methods are often underused as a means to characterize protein behavior in discovery and development of Biologics. Most commonly, 1D PROFILE offers a means to assess differences in proteins for batch to batch comparability and biosimilar applications and is the first step in providing a relatively fast, low-resolution option to assess the solution behavior of proteins. We build the next step using DOSY methods to define a Diffusion Profile that defines protein behavior as a distribution of sizes and association states to capture complexities such as self-interactions or aggregation. Lastly we show how coupling information from DOSY and 1H R2 measurements can further refine our understanding of behavior by profiling motions as well as interactions. Combined, these three methods provide an NMR Toolbox that can be used to rapidly characterize behavior, aid in formulation screening and address developability of Biologics under relevant formulation conditions.
6:00 pm Dinner (in Frick Atrium)
7:00 pm Seminar (in Seminar Room A57)
Dinner Cost (pay at the door):
$10 employed, $5 for students, postdoc, retired, unemployed. No charge for seminar only.
Frick Chemistry Laboratory
Princeton, NJ 08544 [ directions ]
Parking: Parking will be available in Lot 21 (see map link given above under Directions)
Public Transit: It is possible to take NJ Transit all the way to Princeton campus (the symposium location is ~ 10 min walk from the train station). Take the Northeast Corridor NJ transit train to Princeton Junction, then transfer to the small “dinky” train that ends on campus (5 min train ride).
or Bradley.Falk@bms.com (Co-Chair)
Please register online [ here ]
or via e-mail to