The North Jersey ACS NMR Topical Group is pleased to present its February meeting at Princeton, Wednesday, February 13, 2019 [ register ]
Dr. Bruce A Johnson, PhD
Structural Biology Initiative,
Advanced Science Research Center,
The Graduate Center of the City University of New York
“NMRFx: A new integrated software suite for NMR data analysis with applications to biomolecular NMR”
Knowing the structure, dynamics and ligand binding specificity of proteins and nucleic acids is essential to understanding the mechanisms of human disease and to the optimal design of molecules that can intervene therapeutically in disease processes. Nuclear Magnetic Resonance (NMR) Spectroscopy is one of the most versatile techniques for obtaining this molecular information. The optimal use of this information requires complex data analysis including signal processing, chemical shift assignment and structure calculation. In this talk I’ll describe our work on a new integrated software suite for NMR data analysis. This new software, NMRFx, is a cross platform tool running on MacOs, Linux and Windows and builds on our previous experience in developing NMRviewJ. I’ll illustrate the software suite with applications to the assignment of RNA molecules that incorporates data processing, chemical shift prediction and a new visual assignment tool that has applications to RNA, peptides and medicinal chemicals.
6:00 pm Dinner (in Frick Atrium)
7:00 pm Seminar (in Seminar Room A57)
$15 employed / $10 students, postdoc, retired, unemployed. No charge for seminar only.
Frick Chemistry Laboratory, Room A57
Princeton, NJ 08544 [ Directions ]
Parking: Lot 21 (see map link under Directions)
Public Transit: It is possible to take NJ Transit all the way to Princeton campus (the symposium location is ~ 10 min walk from the train station). Take the Northeast Corridor NJ transit train to Princeton Junction, then transfer to the small “dinky” train that ends on campus (5 min train ride).
Qi.Gao1@merck.com (Chair) or
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