North Jersey Section
American Chemical Society

Jan 16, 2019 – NMR Topical Group Meeting

The North Jersey ACS NMR Topical Group is pleased to presents its March meeting at Rutgers, Wednesday, January 16, 2019  [ register ]

Featured Presentation

Justyna Sikorska, PhD

Senior Scientist, Merck & Co., Inc.

Justyna Sikorska

“Identification of Biologically Relevant Scaffolds and their Binding Modes”

Abstract

The NMR is an invaluable technique that can be implemented at the different stages of drug discovery process, ranging from identification of new drug lead to optimization of their binding pharmacophore and establishment of their structure-activity relationships. My research interests have evolved around different aspects of NMR application to drug discovery. To date I worked in two different research areas: biological testing, isolation, structure elucidation of natural products and development of Intermolecular NOEs for Pharmacophore Mapping (INPHARMA ) method enabling determination of the ligand binding mode. Therefore, in the first part of my talk I will demonstrate the extended scope of natural products isolation and elucidation to very limited quantities of pure metabolites. In the second part of my talk I will cover application of INPHARMA method for the identification of ligand binding poses with accuracy high enough to be applicable for pharmacophore design and virtual screening.

Program

6:00 pm Dinner
7:00 pm Seminar

Dinner Cost (pay at the door):

$15 employed / $5 students, postdoc, retired, unemployed. No charge for seminar only.

Meeting Venue

CABM (Center for Advanced Biotechnology and Medicine)
Room 010
Rutgers, 679 Hoes Lane West
Piscataway, NJ 08854 [ directions ]
Parking: Parking will be available in the front of CABM (see map link given above under Directions)

Questions:

Qi.Gao1@merck.com (Chair)
or Justyna.Sikorska@merck.com

Register:

Please register online [ here ] or via e-mail to
Qi.Gao1@merck.com or
Justyna.Sikorska@merck.com

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