The North Jersey ACS NMR Topical Group is pleased to presents its March meeting at Rutgers, Tuesday, November 13, 2018 [ register ]
Prof. Nathaniel Nucci, PhD
Assistant Professor, Rowan University, Department of Medical & Translational Sciences
“Resolving the Dynamic Dance between Proteins and Solvent using NMR and Reverse Micelles”
The critical role of solvent in thermodynamically driving protein structure and function has long been recognized, yet significant controversy persists over the details of how water interacts with proteins. This fundamental gap in our basic understanding of protein systems is largely due to the paucity of experimental data regarding how water and proteins move with respect to one another at the atomic level. While the enthalpic contributions to protein structure-function relationships are well understood, the entropic contributions remain largely a mystery and the fast dynamics of water and protein provide an important window to entropy. Recent studies using nuclear magnetic resonance (NMR) have shed exciting new light on the entropic nature of proteins and of their solvating water. These experiments have revealed a likely functional role for the internal entropy of proteins and for the entropy of the water that solvates them. These recent findings and their implications for understanding protein function will be discussed. New studies using NMR and fluorescence techniques to understand anomalous diffusion in cells will also be summarized.
6:00 pm Dinner
7:00 pm Seminar
Dinner Cost (pay at the door):
$15 employed / $5 students, postdoc, retired, unemployed. No charge for seminar only.
CABM (Center for Advanced Biotechnology and Medicine)
Rutgers, 679 Hoes Lane West
Piscataway, NJ 08854 [ directions ]
Parking: Parking will be available in the front of CABM (see map link given above under Directions)
or Qi.Gao1@merck.com (Co-Chair)
Please register online here
or via e-mail to