North Jersey Section
American Chemical Society

April 12, 2022 – MSDG Meeting

NJ-ACS Mass Spec Discussion Group


The NJ Mass Spectrometry Discussion Group is pleased to announce our April 12, 2022 Meeting — Online!

NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:.....Tuesday April 12, 2022

Time:.....7:00 PM | (UTC-05:00) Eastern Time (US & Canada)

Via:......Webex

Cost:.....Free

Join:.....[ below ]

Sponsor:..Bruker

Bruker

Program

Hanno SteenSpeaker 1: Hanno Steen, PhD, Director of Proteomics and Associate Professor, Department of Pathology, Boston Children’s Hospital and Harvard Medical School, Boston, MA, USA

“Scaling up while scaling down – Sample-sparing High Throughput Proteomics”

Abstract:

Abstract:  Since its inception, proteomics was poised to revolutionize clinical diagnostics by providing novel biomarkers. Currently, however, proteomics has not met its own expectations particularly because large population sizes are required for meaningful biomarkers that can account for genetic, environmental and lifestyle variance. A main bottleneck has been the suboptimal throughput. Enabling throughput will allow the robust processing and analysis of statistically meaningful samples numbers, i.e., hundreds to thousands of samples within a reasonable timeframe. Our recent, involvement in several NIAID immunophenotyping studies focused on understanding COVID-19 impact on the immune system, the efficacy of vaccination, and ontogeny in early life with thousands of plasma samples, highlighted the importance of increasing throughput in collecting high quality data while simultaneously decreasing the amount of required starting material. The Steen Lab has developed a high throughput proteomics platform that allows for the robust processing and analysis of such large numbers of plasma samples. These efforts leveraged the methodology and experience of the Steen Lab to process and analyze hundreds of urine samples with the aim of identifying non-invasive biomarker candidates. The presentation will describe method development from the Steen Lab towards i) high throughput proteomics, ii) improved depth of the plasma proteome, and iii) meta-analyses converting many small studies and datasets into a large dataset with statistical relevance. Our platform which incorporates these approaches will enable the analysis of small volumes of large sample numbers which will bring allow us to understand deviations from normal despite natural interpersonal variability, i.e., truly personalized medicine.
Matt WilletSpeaker 2: Matt Willets, US Proteomics Applications Manager, Bruker

Ultra-sensitive 4D Proteomics on the timsTOF SCP mass spectrometer


Abstract:

Abstract:  The timsTOF SCP is the first commercially introduced mass spectrometer for single cell proteomics. The modified front end (orthogonal ion guide) and the brighter ion beam increase the ion transfer up to five times while maintaining instrument high robustness. In this presentation, we will show how the ultra-high sensitivity of the timsTOF Pro can benefit workflows from immunopeptidomics to single cell analysis

Pre-registration is not required.  Just join at the appointed time

NJACS MSDG invites you

to a Webex meeting.

NJ-ACS Mass Spectrometry Discussion Group Virtual Meeting

Tuesday, April 12, 2022

7:00 pm | Eastern Time | 1 hr 15 mins

JOIN MEETING

More ways to join:

Join from the meeting link:

https://njacsmsdg.my.webex.com/njacsmsdg.my/j.php?MTID=m1e203489cf1f1889aa56b4f2851a4b60

Join by meeting number:

Meeting number (access code): 2556 896 6928

Meeting Password: 6543212

        (also 654321 from phones and video systems)

Join by phone (voice only):

+1-510-338-9438  (USA Toll)

Access code: 2556 896 6928

Or by a single tap on a mobile phone (voice only):

+1-510-338-9438,,25568966928  (USA Toll)

Global call-in numbers

Join by video system, application or Skype for business

Dial 1825116738@webex.com

You can also dial 173.243.2.68 and enter the meeting number.

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