The NJ Mass Spectrometry Discussion Group is pleased to announce our December 8, 2021 Meeting — Online!
NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]
Date:.....Wednesday December 8, 2021
Time:.....7:00 PM | (UTC-05:00) Eastern Time (US & Canada)
Join:.....[ below ]
Speaker 1: Dr. Ying Zhang, Pfizer
Streamlining and Accelerating Peptide Multi-Attribute Method (MAM) Analysis with a BioAccord MAM Workflow to Enhance Product Knowledge”
Development of biopharmaceuticals requires a thorough understanding of product quality attributes (PQAs) and impurities to ensure that the product meets desired safety and efficacy profiles. Multi-attribute method (MAM), based on LC-MS peptide mapping technology, enables direct site-specific monitoring of challenging PQAs and allows enhanced product and process understanding. In this presentation, we will demonstrate how we utilize a BioAccord MAM workflow to increase our product knowledge through both PQA monitoring and new peak detection.
Speaker 2: Dr. Jennifer Nguyen, Waters Corporation
“Rapid Analysis of Synthetic mRNA Cap Structure Using Ion-Pairing RPLC with MaxPeak™ Premier Columns and the BioAccord LC-MS System”
The 5’ cap of mRNA is vital to characterize in vaccine development. Ion-pairing reversed phase liquid-chromatography mass spectrometry (LC-MS) can be used to analyze pre-defined 5’ fragments of synthetic mRNA. However, accurate quantitation can be difficult to achieve due to non-specific binding with the system. Moreover, the choice of ion-pairing system can heavily influence the quality and sensitivity of the mass spectra.
We developed a rapid and sensitive LC-MS method applicable to synthetic mRNA capping using MaxPeak™ Premier Columns in combination with the compliance-ready BioAccord LC-MS system. Analysis of 5’ capping of IVT mRNA preparations could be achieved in less than 5-minutes. Linearity was demonstrated to detecting product-related impurities down to less than 0.1% of the target 5’ capped fragment.
Pre-registration is not required. Just join at the appointed time
NJACS MSDG invites you
to a Webex meeting.
NJ-ACS Mass Spectrometry Discussion Group Virtual Meeting
Wednesday, December 8, 2021
7:00 pm | Eastern Time | 1 hr 15 mins
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