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The NJ Mass Spectrometry Discussion Group is pleased to announce our December 8, 2021 Meeting — Online!
NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area.
Time:.....7:00 PM | (UTC-05:00) Eastern Time (US & Canada)
Join:.....[ below ]
Speaker 1: Dr. Ying Zhang, Pfizer
Streamlining and Accelerating Peptide Multi-Attribute Method (MAM) Analysis with a BioAccord MAM Workflow to Enhance Product Knowledge”
Abstract: Development of biopharmaceuticals requires a thorough understanding of product quality attributes (PQAs) and impurities to ensure that the product meets desired safety and efficacy profiles. Multi-attribute method (MAM), based on LC-MS peptide mapping technology, enables direct site-specific monitoring of challenging PQAs and allows enhanced product and process understanding. In this presentation, we will demonstrate how we utilize a BioAccord MAM workflow to increase our product knowledge through both PQA monitoring and new peak detection.
Speaker 2: Dr. Jennifer Nguyen, Waters Corporation
“Rapid Analysis of Synthetic mRNA Cap Structure Using Ion-Pairing RPLC with MaxPeak™ Premier Columns and the BioAccord LC-MS System”
Abstract: The 5’ cap of mRNA is vital to characterize in vaccine development. Ion-pairing reversed phase liquid-chromatography mass spectrometry (LC-MS) can be used to analyze pre-defined 5’ fragments of synthetic mRNA. However, accurate quantitation can be difficult to achieve due to non-specific binding with the system. Moreover, the choice of ion-pairing system can heavily influence the quality and sensitivity of the mass spectra. We developed a rapid and sensitive LC-MS method applicable to synthetic mRNA capping using MaxPeak™ Premier Columns in combination with the compliance-ready BioAccord LC-MS system. Analysis of 5’ capping of IVT mRNA preparations could be achieved in less than 5-minutes. Linearity was demonstrated to detecting product-related impurities down to less than 0.1% of the target 5’ capped fragment.
Pre-registration is not required. Just join at the appointed time
NJACS MSDG invites youto a Webex meeting.
NJ-ACS Mass Spectrometry Discussion Group Virtual MeetingWednesday, December 8, 2021
More ways to join:
Join from the meeting link:
Join by meeting number:
Meeting number (access code): 2559 427 5257
Meeting Password: axP5cDbSs22
(29752327 from phones and video systems)
Join by phone (voice only):
+1-510-338-9438 (USA Toll)
Access code: 2559 427 5257
Or by a single tap on a mobile phone (voice only):
+1-510-338-9438,,25594275257 (USA Toll)
Join by video system, application or Skype for business
You can also dial 184.108.40.206 and enter the meeting number.
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