Dr. Aalim Weljie
Perelman School of Medicine, University of Pennsylvania
“Relaxing with chronobiology: the role of quantitative NMR spectroscopy in metabolomics studies of sleep
Sleep and circadian rhythm studies have recently benefited from metabolomics analyses, uncovering new connections of chronobiology and metabolism. From quantitative nuclear magnetic resonance (NMR) to untargeted mass spectrometry (MS), a diversity of analytical approaches has been applied to elucidating diurnal patterns in metabolites. In this talk, I consider the advances in the metabolomics toolbox which have yielded significant variability in metabolites across multiple sleep and circadian studies, and specifically discuss the role of quantitative NMR spectroscopy. Study design and data processing measures essential for detecting rhythmicity in metabolomics data will also be discussed. I will highlight our studies of circadian metabolism and sleep disorders such as insomnia to provide a practical example of how NMR can be employed in this arena and what benefits it provides. Future developments in these technologies are anticipated vis-à-vis validating these early findings, given that metabolomics has only recently entered the ring with other systems biology assessments in chronobiology studies.
6:00 pm Dinner
7:00 pm Seminar
$15 employed / $5 students, postdoc, retired, unemployed. No charge for seminar only.
Frick Chemistry Atrium (dinner),
Frick Chemistry room A57 (seminar),
Princeton University, Princeton NJ 08540
Parking: Parking will be available in Lot 21 (see map link given above under Directions)
Public Transit: It is possible to take NJ Transit all the way to Princeton campus (the symposium location is ~ 10 min walk from the train station). Take the Northeast Corridor NJ transit train to Princeton Junction, then transfer to the small “dinky” train that ends on campus (5 min train ride).