North Jersey Section
American Chemical Society

Apr 28, 2021 – MSDG Meeting

NJ-ACS Mass Spec Discussion Group


The NJ Mass Spectrometry Discussion Group is pleased to announce our April 2021 Meeting — Online!

NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:.....Wednesday April 28, 2021

Time:.....7:00 - 8:15 PM

Via:......Webex

Cost:.....Free

Join:.....[ below ]

Sponsor:..MOBILion Systems Inc.

MOBILion Systems Inc.

Program

Speaker 1: Daniel DeBord

PhD, Director of R&D MOBILion Systems Inc.

“Is Structures for Lossless Ion Manipulation (SLIM) a One Trick Pony or a One Stop Shop for Ion Mobility-Mass Spectrometry Analysis?”

Abstract:

Abstract:  Since its introduction in 2014, SLIM has been used to demonstrate unprecedented levels of ion mobility resolution and the potential impact of this resolution on both the depth and throughput of analysis.Integration has focused on the combination of high-resolution ion mobility (HRIM) with high resolution mass spectrometry (HRMS) in the form of time of flight instrumentation. This system configuration provides broad spectrum acquisition along with fast analysis times, making it most suitable for discovery or characterization analyses where the goal is to see “everything” with as much specificity as possible.

Researchers at MOBILion have been working to evolve SLIM functionality to also support targeted applications where the goal is instead to focus on a certain number of analytes, but to be able to detect them as accurately and sensitively as possible, even within complex biological matrices. This presentation will provide an overview of these various designs of the SLIM and show how this platform technology can be tailored to enhance the performance of all types of mass spectrometric detection.

Speaker 2: Jeffrey Agar

PhD, Associate Professor of Chemistry and Pharmaceutical Science at Northeastern University's Barnett Institute

“Top-down- and ion mobility MS-enabled drug discovery for ALS”

Abstract:

Abstract:  We have employed top-down MS to discover ALS-related structural changes to SOD1, an ALS-associated protein. Topics will include custom-made antibodies to purify SOD1 (which can cause ALS) from ALS patients; using ultrahigh resolution MS to determine the sites of PTMs and how these modifications effect SOD1 higher-order structure; determining which modifications are disease-relevant using neurotoxicology assays; and the development of a novel, privileged chemistry using modified cyclic disulfides, for preventing oxidative PTMs and stabilizing proteins.

Pre-registration is not required.  Just join at the appointed time

NJACS MSDG invites you

to a Webex meeting.

NJ-ACS Mass Spectrometry Discussion Group Virtual Meeting -- Hosted by MOBILion Systems Inc.

Wednesday, April 28, 2021

7:00 pm | Eastern Time | 1 hr 15 mins

JOIN MEETING

More ways to join:

Join from the meeting link:

https://njacsmsdg.my.webex.com/njacsmsdg.my/j.php?MTID=m6259274ea15ade2e5e42aac0aeab1778

Join by meeting number:

Meeting number (access code): 182 837 8684

Meeting Password: aFHN2U2jgx5

        (23462825 from phones and video systems)

Join by phone:

+1-510-338-9438  (USA Toll)

Access code: 182 604 4539

Join by video system, application or Skype for business

Dial 1828378684@webex.com

you can also dial 173.243.2.68 and enter the meeting number.

Need help? Go to https://help.webex.com

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