North Jersey Section
American Chemical Society

Oct 18, 2017 – MSDG Meeting

NJ-ACS Mass Spec Discussion Group
The NJ Mass Spectrometry Discussion Group is pleased to announce our October Monthly Meeting.
NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:    Wednesday October 18, 2017

Venue:   Franklin Plaza Hotel   (formerly named Holiday Inn Somerset-Bridgewater)

     195 Davidson Avenue, Somerset, NJ 08873

Sponsor: Shimadzu

Shimadzu

Please  register here.  Registration is free, compliments to our sponsor.

Program

5:30 PM    Social and Registration  
6:15 PM    Complimentary Dinner
7:00 PM    Welcome and Opening Remarks
7:05 PM    Speakers

Speaker 1:  Prof. Richard B van Breemen

UIC/NIH Center for Botanical Dietary Supplements Research, University of Illinois College of Pharmacy, Chicago, IL; and Linus Pauling Institute, Oregon State University, Corvallis OR

“From the Field to the Clinic, the Role of Mass Spectrometry in Establishing Safety and Efficacy of Botanical Dietary Supplements”

Abstract for Prof van Breemen:

Mass spectrometry has become an essential tool for all stages of drug discovery and development. Similarly, mass spectrometry has broad utility in studies of the safety and efficacy of botanical dietary supplements. These applications to botanical dietary supplements include studies of the mechanisms of action (target identification and validation); identification of active natural products (drug discovery); studies of metabolism of active compounds; investigation of the potential for drug-botanical interactions (similar to studies of drug-drug interactions); and investigation of the pharmacokinetics of active compounds. Mass spectrometry is also being used in support of Phase I, II and III clinical trials of safety and efficacy of botanical dietary supplements. Preclinical and clinical examples will be drawn from studies of botanical dietary supplements such as red clover, black cohosh, hops, and licorice that are being used by menopausal women as alternatives to conventional hormone therapy.

Speaker 2:  Prof. Takeshi Bamba

Medical Institute of Bioregullation, Kyushu Univ., Fukoaka, Japan

“Metabolic profiling y supercritcal fluid extraction and separation technologies”

Abstract for Prof Takeshi Bamba:

Supercritical fluids have desirable properties like high density, low viscosity, and high diffusivity, which make them suitable mobile phases for supercritical fluid chromatography (SFC), an analytical technique that is amenable to high-throughput, high-resolution analysis. We attempted to apply SFC/MS to metabolic profiling. Furthermore, we tried to expand the range of applications of SFC for diverse compounds, including polar compounds. Additionally, we have developed supercritical fluid extraction (SFE) technologies for metabolic profiling. SFE can be used to extract labile compounds without degradation or loss. We applied SFE to the extraction of various metabolites and combined it with online SFC/MS for metabolic profiling. Furthermore, we developed a new online SFE-SFC-MS instrument.

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