Dr. Purnima Khandelwal
“Polyethylene Glycol (PEG) Quantitation in Biofluids supporting Drug Discovery”
Conjugation of macromolecular drugs to polyethylene glycol (PEG) improves their therapeutic potential by enhancing the half-life. As a substantial component of the drug, it is necessary to measure the pharmacokinetic (PK) characteristics of PEG in vivo. A quantitative NMR-based method was developed and applied to measuring 40 kDa PEG in serum, enabling determination of PK parameters in preclinical species. Observed half-life was found to be consistent with 125Iodine-labeled PEG methods. Moreover, urinary quantitation of 20kDa PEG was used to investigate side effects of a pegylated biologic. NMR spectroscopy was shown to be a convenient and reliable alternative to follow pharmacokinetics of PEG in various biofluids.
6:00 pm Dinner
7:00 pm Seminar
Frick Chemistry Atrium (dinner), Frick Chemistry room A81 (seminar), Princeton University, Princeton NJ 08540
$5 for students postdoc, retired, unemployed
No charge for seminar only