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Oct 17, 2013 – DMDG Fall Symposium and Vendor Show

Drug Met Symposium and Vendor Show

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Date: October 17, 2013
Venue: The Palace at Somerset Park, 333 Davidson Avenue, Somerset, NJ 08873.

2009 Fall Symposium and Vendor Exhibition

2013 Fall Symposium and Vendor Exhibition

Sponsored by the

North Jersey ACS

Drug Metabolism Discussion Group

“Biomarkers, Reactive Metabolites, Idiosyncratic Reactions”

The Palace at Somerset Park
333 Davidson Avenue
Somerset, New Jersey 08873
17 October, 2013
8:00 am – 3:45 pm

*Program*
“Biomarkers, Reactive Metabolites, Idiosyncratic Reactions”
8:00 a.m.	Registration / Continental Breakfast / Vendor Exhibit
9:00 a.m.	Introductory Remarks *Dr. Wing Lam, Chair, NJDMDG*
9:10 a.m.	Exploring the Mechanism of Metabolic Intermediate Complex-Based Metabolism-Dependent CYP Inhibition: the Case of Lapatinib *Joanna Barbara, Ph.D., Director of Analytical Services, XenoTech,* *Lenexa, KS*
10:00 a.m.	Altered Drug Metabolism During Pregnancy *Hyunyoung* *(Young) Jeong,* *Pharm.D., Ph.D., Associate Professor, Department of Pharmacy Practice and Biopharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL*
10:45 a.m.	Vendor Exhibit & Coffee Break
11:30 p.m.	Molecular Imaging Biomarkers for Predicting Treatment Response *Paul D. Acton, Ph.D., Scientific Director & Janssen Fellow, Global Head, Molecular Imaging, Janssen Research and Development, Spring House, PA*
12:15 p.m.	Lunch & Vendor Exhibit
1:45 p.m.	Why are Idiosyncratic Drug Reactions Idiosyncratic *Jack Uetrecht, M.D., Ph.D.,* *Professor of Pharmacy and Medicine,* *University of Toronto, Toronto, ON*
2:30 p.m.	Vendor Exhibit & Coffee Break
3:00 p.m.	Coadministration of Ritonavir (RTV) with the HCV Protease Inhibitor Danoprevir (DNV) Substantially Reduces Reactive Metabolite Formation: In Vitro and In Vivo Data *Bonnie Brennan , Pharm.D., Senior Principal Scientist, Department of Clinical Pharmacology at Roche, Nutley, NJ*
3:45 p.m.	Program Closure

NJ-DMDG Steering Committee 2013-2014:

Name	Company	E-mail address	Role
Wing Lam	Janssen R&D	wlam@its.JnJ.com	Chair, 2013-14
Philip Krieter	Warner Chilcott	pakrieter@verizon.net	Treasurer
Matthew Hoffmann	Celgene	mjhoffman@celgene.com	Vice-Treasurer
Karen H. Dingley	Merck Research	karen_dingley@merck.com	Vendor Liaison
Allen Jones	Roche	allen.n.jones@verizon.net	Past Chair, 2012-13
Lian Zhou	BMS	Lian.zhou@bms.com	Past Chair, 2011-12
Imad Hanna	Novartis	imad.hanna@novartis.com	Past Chair, 2010-11
Roseann Affinito	KCAS Bio	roseannaffinito@optonline.net	Member
Lauren Aleksunes	Rutgers University	aleksunes@eohsi.rutgers.edu	Member
Shiying Chen	Merck Research	shiying.chen@merck.com	Member
Karl Frank	Roche	karl_b.frank@roche.com	Member
Rong Kong	PTC Therapeutics	rkong@ptcbio.com	Member
Maria Markowska	Janssen R&D	MMarkows@its.jnj.com	Member
Zhao pie Zeng	Sanofi-aventis	Zhaopie.Zeng@sanofi-aventis.com	Member
Lei Tang	Sanofi-aventis	Lei.Tang@sanofi-aventis.com	Member
Richard Tschirret-Guth	Merck Research	richard_tschirretguth@merck.com	Member
Bo Wen	GSK	bo.1.wen@gsk.com	Member
Manthena Varma	Pfizer	Manthena.V.Varma@pfizer.com	Member
Li Yu	Roche	li.yu.ly1@roche.com	Member
Yaofeng Cheng	BMS	Yaofeng.Cheng@bms.com	Member
Carolina Cabral		cbcabral@gmail.com	Member

Registration:

Pre-registration fee is $125 (pre-register by 10 October 2013).

Registration is Free for students and unemployed (with proper identification).

Registration fee at the door is $150 (Checks only).

• Please plan to pre-register as a group, as coordinated by a member of the NJACS DMDG steering committee from your organization (see list above).

• If you have no DMDG member at your company, please contact Wing Lam (mwlam@its.jnj.com) for registration.

• Payments by personal or company checks. Sorry, credit cards are not accepted.

• Checks should be made payable to: NJ Drug Metabolism Discussion Group.

• Please also visit our website: http://www.njacs.org/topical-groups/drug-metabolism

Exhibitors:

• Please contact Karen Dingley (karen_dingley@merck.com) for information concerning exhibits

Directions to the Palace at SomersetPark

333 Davidson Avenue, Somerset, NJ 08873 08873 [ website ]

Phone: 732-302-9922

From the New Jersey Turnpike:

Exit 10 to Interstate 287 North. Follow 10 miles to Exit 10 (527 New Brunswick-South Bound Brook). Easton Ave towards South Bound Brook to first light, make left (Davidson Ave.)

From New York City:

Lincoln Tunnel to N.J. Turnpike South. Follow N.J. Turnpike directions mentioned above.

From Route 287:

If traveling north:

Exit 10 (527 New Brunswick-South Bound Brook). Follow sign towards Bound Brook, to light make left (Davidson Ave.)

If traveling south:

Exit 10 (527 New Brunswick). Left on Easton Ave., to light, make left (Davidson Ave).

From the Newark Airport

Take NJ Turnpike South to Exit 10- I-287 North to Exit 10 (Easton Ave) to first light, go left on Davidson Ave. Hotel immediately on left.

✎ 2013-10-17

(Past Events)

Apr 18, 2013 – DMDG Spring Symposium & Vendor Show

“Models, Pharmacogenomics, Pharmacokinetics”

Venue: Hotel Somerset Bridgewater (formerly Crowne Plaza, formerly Somerset Plaza), 110 Davidson Avenue, Somerset, NJ 08873. [ directions ]

Exhibitor Info

Please contact Karen Dingley at karen_dingley@merck.com for information concerning exhibits.

Program [ program book ]

08:00 am — Registration / Continental Breakfast / Vendor Exhibit

09:00 am
Introductory Remarks
Dr. Allen Jones, Chair, NJDMDG

09:10 am
“Novel Hepatic Model Systems for Investigating Mechanisms of Drug-Induced
Liver Injury (DIU)”
Edward L. LeCluyse, Ph.D. , Associate Investigator Institute for Chemical Safety Sciences The Hamner Institutes for Health Sciences, Research Triangle Park, NC

10:00 am
“Pharmacogenomics in American Indian Populations”
Erica L. Woodahl, Ph.D. , Associate Professor Department of Biomedical and Pharmaceutical Sciences University of Montana, MT [ slides ]

10:45 am — Vendor Exhibit & Coffee Break

11:30 am
“Pharmacokinetics of Proteins and Peptides”
Joseph P. Balthasar, Ph.D. , Professor of Pharmaceutical Sciences, State University of New York at Buffalo, Buffalo, NY

12:15 pm — Lunch & Vendor Exhibit

1:45 pm
“Glucuronidation, sulfation, and pharmacokinetics of conjugated metabolite”
Swati Nagar, Ph.D. , Associate Professor, Temple University School of Pharmacy, Philadelphia, PA [ slides ]

2:30 pm — Vendor Exhibit & Coffee Break

3:00 pm
“A panel of translational xenoreceptor, cytochrome P450, transporter and transplanted liver humanized mouse models for improved prediction of drug responses in Man”
Nico Scheer, Ph.D., Head of the tADMET^TM portfolio, Taconic Farms, Inc., Cranbury, NJ [ slides ]

3:45 pm — Program Closure

Directions to the Hotel Somerset Bridgewater

Hotel Somerset Bridgewater was formerly Crowne Plaza, formerly Somerset Plaza
110 Davidson Avenue, Somerset, NJ 08873
Phone: 732-560-0500

From the New Jersey Turnpike:
Exit 10 to Interstate 287 North. Follow 10 miles to Exit 10 (527 New Brunswick-South Bound Brook). Easton Ave towards South Bound Brook to first light, make left (Davidson Ave.)
From New York City:
Lincoln Tunnel to N.J. Turnpike South. Follow N.J. Turnpike directions mentioned above.
From Route 287:
- If traveling north: Exit 10 (527 New Brunswick-South Bound Brook). Follow sign towards Bound Brook, to light make left (Davidson Ave.)
- If traveling south: Exit 10 (527 New Brunswick). Left on Easton Ave., to light, make left (Davidson Ave).
From the Newark Airport
Take NJ Turnpike South to Exit 10- I-287 North to Exit 10 (Easton Ave) to first light, go left on Davidson Ave. Hotel immediately on left.