North Jersey Section
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(Past Events)

Apr 30, 2020 – DMDG Spring Symposium and Vendor Exhibition


NJ-DMDG

Sponsored by the

North Jersey ACS Drug Metabolism Discussion Group

“Novel Drug Delivery Approaches”

[ program ]

NOTICE: This symposium is postponed to Sept 10 (tentative date).

In light of the evolving situation with the COVID-19 viral outbreak in the US and the world, it is with the deepest regret that we make the difficult decision to postpone the Spring Symposium to September 10, 2020 (tentative date).  Besides our concern for the health of our participants, many local companies, vendors and contract research organizations have issued travel guidelines that restrict or prohibit associates from attending conferences, which would greatly limit the size of the audience at the meeting in April.

Imad Hanna
NJ-DMDG chair


 

Date:   April 30, 2020

Time:   8:00 am – 4:00 pm

Venue:  The Palace at Somerset Park,
        333 Davidson Avenue,
        Somerset, NJ 08873     [ directions ]

Registration Information:

  • Pre-registration fee is $125 (pre-register by April 23, 2020).
  • Registration fee at the door is $150 (Checks only)
  • Registration fee is $10 for students and postdocs and $50 for faculty
  • Registration is free for unemployed

Please plan to pre-register as a group, as coordinated by a member of the NJACS DMDG Steering Committee List, below, from your organization.

  • If you have no DMDG member at your company, please contact Elizabeth Joshi (elizabeth.joshi@merck.com) for registration.
  • Payments by personal or company checks. Sorry, credit cards are not accepted.
  • Checks should be made payable to: NJ Drug Metabolism Discussion Group.

Exhibitors:

top

Program

“Novel Drug Delivery Approaches”
8:00 a.m.

Registration / Continental Breakfast / Vendor Exhibit
9:00 a.m.

Introductory Remarks

Imad Hanna, Chair, NJ DMDG
9:15 a.m.

SiRNA delivery of GalNac-conjugated molecules

Diane Ramsden, Principal Scientist, Alnylam, Cambridge, MA
10:00 a.m.

Cell-selective prodrugs for molecular targeted drug delivery

John Isbell, PhD, Director, Drug Metabolism and Disposition. Genomics Institute of the Novartis Research Foundation, San Diego, CA
10:45 a.m.

Vendor Exhibit & Coffee Break
11:15 a.m.

Stem cell-directed targeted enzyme/prodrug therapy of cancer

Arash Hatefi, Associate Professor, Department of Pharmaceutics, Rutgers, The State University of New Jersey.
12:00 p.m.

Lunch & Vendor Exhibit
1:15 p.m.

Nano particle drug conjugates for efficient delivery to biological targets

Liang Zhao, PhD, Department of Microbiology and Immunology Albert Novartis Institutes for BioMedical Research, Cambridge, MA
2:00 p.m.

Pharmacokinetic modeling of CNS disposition of 5-HT3 receptor antagonist with quantitative assessment of the role of P-glycoprotein efflux

Manting Chiang, PhD, Graduate Student, Pharmaceutical Sciences, Rutgers, The State University of New Jersey. Current affiliation: Clinical Pharmacology & Pharmacometrics, Bristol Meyers Squibb, Princeton, NJ
2:45 p.m.

Vendor Exhibit & Coffee Break
3:00 p.m.

Biopharmaceutical characteristics and drug delivery strategies for peptides/ASOs/targeted protein degraders

John Morrison, PhD, Pharmaceutical Candidate Optimization, Bristol Meyers Squibb, Princeton, NJ
3:45 p.m.

Program closure


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NJ-DMDG Steering Committee 2019-2020
Name Company E-mail address Responsibility
Imad Hanna Novartis imad.hanna@novartis.com Chair (2019-2020)
Beth Joshi Merck elizabeth.joshi@merck.com Past Chair (2018-2019)
Manthena Varma Pfizer Manthena.V.Varma@pfizer.com Past Chair, 2017-18
Matthew Hoffmann Celgene mjhoffman@celgene.com Treasurer
Naiyu Zheng BMS naiyu.zheng@bms.com Vendor Liaison (2018-2020)
Anima Ghosal Kean University ghosala@aol.com Vendor Liaison
Bo Wen GSK bo.1.wen@gsk.com Past Chair, 2016-17
Lauren Aleksunes Rutgers University aleksunes@eohsi.rutgers.edu Past Chair, 2015-16
Carlo Sensenhauser Janssen R&D CSensenh@its.JnJ.com Member
Allen Jones Students 2 Science allen.n.jones@verizon.net Member
Ron Kong PTC Therapeutics rkong@ptcbio.com Member
Lei Tang Sanofi Lei.Tang@sanofi.com Member
Li Yu Roche li.yu.ly1@roche.com Member
Maria Markowska Mmaryla5@yahoo.com Member
Fan Wu Celgene fwu@celgene.com Member
Hong Shen BMS hong.shen1@bms.com Member

 

top

Directions to the Palace at Somerset Park

    333 Davidson Avenue, Somerset, NJ 08873
    Phone: 732-302-9922
    [ website ]

From the New Jersey Turnpike:

    Exit 10 to Interstate 287 North.
    Follow 10 miles to Exit 10 (527 New Brunswick -- South Bound Brook).
    Take Easton Ave towards South Bound Brook to first light.
    Make left (Davidson Ave).

From New York City:

    Lincoln Tunnel to N.J. Turnpike South.
    Follow N.J. Turnpike directions mentioned above.

From Route 287:

    If traveling north:

      Exit 10 (527 New Brunswick -- South Bound Brook)
      Follow sign towards Bound Brook, to light.
      Make left (Davidson Ave).

    If traveling south:

      Exit 10 (527 New Brunswick).
      Left on Easton Ave., to light.
      Make left (Davidson Ave).

From Newark Airport:

    Take NJ Turnpike South to Exit 10
    I-287 North to Exit 10 (Easton Ave).
    At first light, go left on Davidson Ave.
    Hotel immediately on left.

top

✎ 2020-04-30

(Past Events)

May 9, 2019 – Spring Symposium and Vendor Exhibition

NJ-DMDG

2019 Spring Symposium & Vendor Exhibition

Sponsored by the

North Jersey ACS Drug Metabolism Discussion Group

“From Small Molecule to Large – Modality Expansion and Impact within Drug Disposition”


Date:   May 9, 2019

Time:   8:00 am – 4:00 pm

Venue:  The Palace at Somerset Park,
        333 Davidson Avenue,
        Somerset, NJ 08873     [ directions ]

Registration Information:

  • Pre-registration fee is $125 (pre-register by May 2, 2019).
  • Registration fee at the door is $150 (Checks only)
  • Registration fee is $10 for students and postdocs and $50 for faculty
  • Registration is free for unemployed
Please plan to pre-register as a group, as coordinated by a member of the NJACS DMDG Steering Committee List, below, from your organization.
  • If you have no DMDG member at your company, please contact Elizabeth Joshi (elizabeth.joshi@merck.com) for registration.
  • Payments by personal or company checks. Sorry, credit cards are not accepted.
  • Checks should be made payable to: NJ Drug Metabolism Discussion Group.

Exhibitors:


Program

“From Small Molecule to Large – Modality Expansion and Impact within Drug Disposition”

 8:00 a.m.

                        Registration / Continental Breakfast / Vendor Exhibit

 9:00 a.m.

Introductory Remarks

Elizabeth Joshi, Chair, NJ DMDG

 9:15 a.m.

The Role of DMPK in Supporting Therapeutic Proteins in a Drug Discovery Setting

Larry Wienkers, PhD, Principal Scientist, Wienkers Consulting

 10:00 a.m.

Applications of Minimal PBPK Models to Understand the Effect of FcRn on Monoclonal Antibody System Persistence

Yanguang (Carter) Cao, Ph.D., Assistant Professor | Division of Pharmacotherapy and Experimental Therapeutics | UNC Eshelman School of Pharmacy

 10:45 a.m.

            Vendor Exhibit & Coffee Break

 11:15 a.m.

Prediction of in vivo molecular stability of protein therapeutics through in vitro assessment of kinetic stability

Kevin Cook, Senior Scientist - PKDM, Amgen

 12:00 p.m.

            Lunch & Vendor Exhibit

 1:15 p.m.

Preclinical PK/TE/PD Approach and Application for First-in-Human Dose Selection of a Therapeutic Antibody Targeting a Checkpoint Receptor

Yanbin Lao, PhD, Principal Research Scientist, Eli Lilly and Company

 2:00 p.m.

Engineered “Smart” Insulin: Insulin-Carbohydrate Conjugates with Responsivity to Physiological Levels of Glucose

SongnianLin , PhD, Director – Discovery Chemistry, Merck Research Laboratories, Kenilworth, NJ

 2:45 p.m.

            Vendor Exhibit & Coffee Break

 3:00 p.m.

Digital nano: Rational Design of Biocompatible Nanomaterials by Virtual Nano Library Techniques and Artificial Intelligence

Hao Zhu, Associate Professor – Chemistry, Rutgers University, New Brunswick, NJ

 3:45 p.m.

                          Program closure

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NJ-DMDG Steering Committee 2019-2020
Name Company E-mail address Responsibility
Beth Joshi Merck elizabeth.joshi@merck.com Chair, 2018-19
Imad Hanna Novartis imad.hanna@novartis.com Chair Elect, 2019-20
Matthew Hoffmann Celgene mjhoffman@celgene.com Treasurer
Naiyu Zheng BMS naiyu.zheng@bms.com Vendor Liaison
Manthena Varma Pfizer Manthena.V.Varma@pfizer.com Past Chair, 2017-18
Bo Wen GSK bo.1.wen@gsk.com Past Chair, 2016-17
Lauren Aleksunes Rutgers University aleksunes@eohsi.rutgers.edu Past Chair, 2015-16
Wing Lam Janssen R&D wlam@its.JnJ.com Past Chair, 2013-14
Allen Jones - allen.n.jones@verizon.net Past Chair, 2012-13
Anima Ghosal Kean University ghosala@aol.com Member
Ron Kong PTC Therapeutics rkong@ptcbio.com Member
Lei Tang Sanofi Lei.Tang@sanofi.com Member
Li Yu Roche li.yu.ly1@roche.com Member
Fan Wu Celgene fwu@celgene.com Member
Jin Wu Merck Jin_wu@merck.com Member
Zhao pie Zeng - zhaopiezeng@gmail.com Member
Carolina Berthiaume - carolina.berthiaume@gmail.com Member
Maria Markowska - Mmaryla5@yahoo.com Member

top

Directions to the Palace at Somerset Park

    333 Davidson Avenue, Somerset, NJ 08873
    Phone: 732-302-9922
    [ website ]
From the New Jersey Turnpike:
    Exit 10 to Interstate 287 North. Follow 10 miles to Exit 10 (527 New Brunswick -- South Bound Brook). Take Easton Ave towards South Bound Brook to first light, make left (Davidson Ave.)
From New York City:
    Lincoln Tunnel to N.J. Turnpike South. Follow N.J. Turnpike directions mentioned above.
From Route 287:
    If traveling north:
      Exit 10 (527 New Brunswick -- South Bound Brook). Follow sign towards Bound Brook, to light make left (Davidson Ave.)
    If traveling south:
      Exit 10 (527 New Brunswick). Left on Easton Ave., to light, make left (Davidson Ave).
From Newark Airport:
    Take NJ Turnpike South to Exit 10 I-287 North to Exit 10 (Easton Ave) at first light, go left on Davidson Ave. Hotel immediately on left.

top

✎ 2019-05-09

(Past Events)

Oct 11, 2018 – DMDG FallSymposium and Vendor Exhibition

NJ-DMDG

2018 Fall Symposium & Vendor Exhibition

Sponsored by the

North Jersey ACS Drug Metabolism Discussion Group

“Strategies for Optimizing Pharmacological, Metabolic, and Toxicological Profiles of Clinical Candidates”


Date:   October 11, 2018

Time:   8:00 am – 3:45 pm

Venue:  The Palace at Somerset Park,
        333 Davidson Avenue,
        Somerset, NJ 08873     [ directions ]


NJDMDG Fall Symposium 11 Oct 2018

Speakers & Organizers: Bottom row (L to R): Matt Hoffman (Celgene), Beth Joshi (Merck), Laura Armstrong (Rutgers), Piyush Bajaj (Takeda), Judi Wardwell (InSphero), Li Yu (Roche), Top row (L to R): Murat Cirit (MIT), Imad Hanna (Novartis), Naiyu Zheng (BMS), Dan Mudra (Lilly), Wing Lam (Janssen), Fan Wu (Celgene)

Registration Information:

  • Pre-registration fee is $125 (pre-register by October 5, 2018).
  • Registration fee at the door is $150 (Checks only)
  • Registration fee is $10 for students and postdocs and $50 for faculty
  • Registration is free for unemployed
Please plan to pre-register as a group, as coordinated by a member of the NJACS DMDG Steering Committee List, below, from your organization.
  • If you have no DMDG member at your company, please contact Elizabeth Joshi (elizabeth.joshi@merck.com) for registration.
  • Payments by personal or company checks. Sorry, credit cards are not accepted.
  • Checks should be made payable to: NJ Drug Metabolism Discussion Group.

Exhibitors:


2009 Fall Symposium and Vendor Exhibition

Program

“Strategies for Optimizing Pharmacological, Metabolic, and Toxicological Profiles of Clinical Candidates”

8:00 a.m.

Registration / Continental Breakfast / Vendor Exhibit

9:00 a.m.

Introductory Remarks

Elizabeth Joshi, Chair, NJ DMDG

9:15 a.m.

Mechanistic Modeling at the Discovery-Development Interface: From Design to Dose

Daniel Mudra, PhD, Director, Discovery ADME, Eli Lilly and Company

10:00 a.m.

Translational DMPK Applications of Tissue Chip Technologies

Murat Cirit, PhD, Director, Translational Center of Tissue Chip Technologies at Massachusetts Institute of Technology (MIT)

10:45 a.m.

Vendor Exhibit & Coffee Break

11:15 a.m.

Microphysiological multi-tissue flow-based system utilizing InSphero 3D InSight™ Microtissues: Applications for DMPK, Drug Metabolism and Drug Discovery

Judi Wardwell, Senior Technical Specialist, InSphero Inc.

12:00 p.m.

Lunch & Vendor Exhibit

1:20 p.m.

Model-informed translational strategies to improve upon drug safety risks

Piyush Bajaj, PhD, Scientist II – Investigative Toxicology, Drug Safety Research and Evaluation, Takeda, Cambridge, MA

2:05 p.m.

Hepatic FXR’s Protective Role Against NASH Development in a High-Fat Diet Induced NAFLD Mouse Model

Laura Armstrong, PhD, Post-Doctoral Research Fellow, Rutgers University

2:35 p.m.

Vendor Exhibit & Coffee Break

3:00 p.m.

Novel Metabolite ID Platform for Therapeutic Proteins

Xiang Yu, PhD, Associate Principle Scientist, PPDM Preclinical ADME Metabolite ID, Merck, West Point, NJ

3:45 p.m.

Program Closure

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NJ-DMDG Steering Committee 2018-2019
Name Company E-mail address Responsibility
Beth Joshi Merck elizabeth.joshi@merck.com Chair, 2018-19
Imad Hanna Novartis imad.hanna@novartis.com Chair Elect, 2019-20
Matthew Hoffmann Celgene mjhoffman@celgene.com Treasurer
Naiyu Zheng BMS naiyu.zheng@bms.com Vendor Liaison
Manthena Varma Pfizer Manthena.V.Varma@pfizer.com Past Chair, 2017-18
Bo Wen GSK bo.1.wen@gsk.com Past Chair, 2016-17
Lauren Aleksunes Rutgers University aleksunes@eohsi.rutgers.edu Past Chair, 2015-16
Wing Lam Janssen R&D wlam@its.JnJ.com Past Chair, 2013-14
Allen Jones - allen.n.jones@verizon.net Past Chair, 2012-13
Anima Ghosal Kean University ghosala@aol.com Member
Ron Kong PTC Therapeutics rkong@ptcbio.com Member
Lei Tang Sanofi Lei.Tang@sanofi.com Member
Li Yu Roche li.yu.ly1@roche.com Member
Fan Wu Celgene fwu@celgene.com Member
Jin Wu Merck Jin_wu@merck.com Member
Zhao pie Zeng - zhaopiezeng@gmail.com Member
Carolina Berthiaume - carolina.berthiaume@gmail.com Member
Maria Markowska - Mmaryla5@yahoo.com Member

top

Directions to the Palace at Somerset Park

    333 Davidson Avenue, Somerset, NJ 08873
    Phone: 732-302-9922
    [ website ]
From the New Jersey Turnpike:
    Exit 10 to Interstate 287 North. Follow 10 miles to Exit 10 (527 New Brunswick — South Bound Brook). Take Easton Ave towards South Bound Brook to first light, make left (Davidson Ave.)
From New York City:
    Lincoln Tunnel to N.J. Turnpike South. Follow N.J. Turnpike directions mentioned above.
From Route 287:
    If traveling north:
      Exit 10 (527 New Brunswick — South Bound Brook). Follow sign towards Bound Brook, to light make left (Davidson Ave.)
    If traveling south:
      Exit 10 (527 New Brunswick). Left on Easton Ave., to light, make left (Davidson Ave).
From Newark Airport:
    Take NJ Turnpike South to Exit 10 I-287 North to Exit 10 (Easton Ave) at first light, go left on Davidson Ave. Hotel immediately on left.

top

✎ 2018-10-11

(Past Events)

Apr 20, 2017 – DMDG Spring Symposium and Vendor Exhibition

NJ-DMDG

2017 Spring Symposium & Vendor Exhibition

Sponsored by the

North Jersey ACS Drug Metabolism Discussion Group

“Translating Preclinical Drug Disposition in Clinical Development”

Date:    April 20, 2017
Time:    8:00 am – 3:45 pm
Venue:  The Palace at Somerset Park, 333 Davidson Avenue, Somerset, NJ 08873 [ directions ]

Registration Information:

  • Pre-registration fee is $125 (pre-register by April 15, 2017).
  • Registration fee at the door is $150 (Checks only)
  • Registration fee is $10 for students and postdocs and $50 for faculty
  • Registration is free for unemployed

Please plan to pre-register as a group, as coordinated by a member of the NJACS DMDG Steering Committee List, below, from your organization.

  • If you have no DMDG member at your company, please contact Bo Wen (bo.1.wen@gsk.com) for registration.
  • Payments by personal or company checks. Sorry, credit cards are not accepted.
  • Checks should be made payable to: NJ Drug Metabolism Discussion Group.

Exhibitors:

  • Please contact Anima Ghosal (ghosala@aol.com) for information concerning exhibits

Program

“Translating Preclinical Drug Disposition in Clinical Development”

8:00 a.m.

Registration / Continental Breakfast / Vendor Exhibit

9:00 a.m.

Introductory Remarks

Bo Wen, Chair, NJ DMDG

9:10 a.m.

Metabolomic and Transcriptomic Analysis of BCRP/Abcg2 and PGP/Abcb1 WT and Double KO Rat Tissues to Identify Endogenous, Dietary and Xenobiotic Substrates

Erin Schuetz, PhD, Member, Department of Pharmaceutical Sciences, St Jude Children’s Research Hospital, Memphis, TN

10:00 a.m.

Assays to Guide the Way at NCATS: Drug Transporters and Drug Efficacy

Matthew Hall, PhD, Biology Group Leader, National Center for Advancing Translational Sciences (NCATS) Chemical Genomics Center, National Institutes of Health, Rockville, MD

10:45 a.m.

Vendor Exhibit & Coffee Break

11:30 p.m.

Emerging Role of Non-P450 Enzymes in Drug Metabolism and Toxicity

Deepak Dalvie, PhD, Sr. Principal Investigator, Department of Drug Metabolism and Pharmacokinetics, Celgene, San Diego, CA

12:15 p.m.

Lunch & Vendor Exhibit

1:45 p.m.

Is it Possible to Accurately Predict the Risk that a Drug Candidate Will Cause Idiosyncratic Drug Reactions?

Jack Uetrecht, PhD, Professor of Pharmacy and Medicine and the Canada Research Chair in Adverse Drug Reactions, University of Toronto, Toronto, Ontario, Canada

2:30 p.m.

Vendor Exhibit & Coffee Break

3:00 p.m.

ADME Analysis of Therapeutic Peptides: Preserving Product Value

Jerome Hochman, PhD, Sr. Principal Scientist, Department of Pharmacokinetics Pharmacodynamics and Drug Metabolism, Merck & Co. West Point, PA

3:45 p.m.

Program Closure


top

NJ-DMDG Steering Committee 2016-2017
Name Company E-mail address Responsibility
Bo Wen GSK bo.1.wen@gsk.com Chair, 2016-17
Manthena Varma Pfizer Manthena.V.Varma@pfizer.com Chair Elect, 2017-18
Zhao pie Zeng Sanofi Zhaopie.Zeng@sanofi-aventis.com Treasurer
Anima Ghosal Kean Univ ghosala@aol.com Vendor Liaison
Lauren Aleksunes Rutgers Univ aleksunes@eohsi.rutgers.edu Past Chair, 2015-16
Richard Tschirret-Guth Merck richard_tschirretguth@merck.com Past Chair, 2014-15
Wing Lam Janssen R&D wlam@its.JnJ.com Past Chair, 2013-14
Allen Jones   allen.n.jones@verizon.net Past Chair, 2012-13
Lian Zhou BMS Lian.zhou@bms.com Past Chair, 2011-12
Imad Hanna Novartis imad.hanna@novartis.com Member
Ron Kong PTC Therapeutics rkong@ptcbio.com Member
Lei Tang Sanofi Lei.Tang@sanofi-aventis.com Member
Li Yu Roche li.yu.ly1@roche.com Member
Yaofeng Cheng BMS Yaofeng.Cheng@bms.com Member
Virna Schuck Novartis virna.schuck@novartis.com Member
Naiyu Zheng BMS naiyu.zheng@bms.com Member
Beth Joshi Merck elizabeth.joshi@merck.com Member
Matthew Hoffmann Celgene mjhoffman@celgene.com Member
Karen H. Dingley Celgene kdingley@celgene.com Member
Carolina Berthiaume   carolina.berthiaume@gmail.com Member
Maria Markowska   cMmaryla5@yahoo.com Member


top

Directions to the Palace at Somerset Park

    333 Davidson Avenue, Somerset, NJ 08873
    Phone: 732-302-9922

From the New Jersey Turnpike:

    Exit 10 to Interstate 287 North.
    Follow 10 miles to Exit 10 (527 New Brunswick -- South Bound Brook).
    Take Easton Ave towards South Bound Brook to first light,
    make left (Davidson Ave.)

From New York City:

    Lincoln Tunnel to N.J. Turnpike South.
    Follow N.J. Turnpike directions mentioned above.

From Route 287:

    If traveling north:

      Exit 10 (527 New Brunswick -- South Bound Brook).
      Follow sign towards Bound Brook, to light
      make left (Davidson Ave.)
    If traveling south:

      Exit 10 (527 New Brunswick).
      Left on Easton Ave., to light,
      make left (Davidson Ave).

From Newark Airport:

    Take NJ Turnpike South to Exit 10
    I-287 North to Exit 10 (Easton Ave)
    at first light, go left on Davidson Ave.
    Hotel immediately on left.

top

✎ 2017-04-20

(Past Events)

Oct 13, 2016 – DMDG Fall Symposium and Vendor Exhibition

NJ-DMDG

2016 Fall Symposium & Vendor Exhibition

Sponsored by the

North Jersey ACS Drug Metabolism Discussion Group

“Transforming assessment of Drug Disposition with Novel Methodologies”

Date:    October 13, 2016
Time:    8:00 am – 3:45 pm
Venue:  The Palace at Somerset Park, 333 Davidson Avenue, Somerset, NJ 08873 [ directions ]

Registration Information:

  • Pre-registration fee is $125 (pre-register by Oct 6, 2016).
  • Registration fee at the door is $150 (Checks only)
  • Registration fee is $10 for students and postdocs and $50 for faculty
  • Registration is free for unemployed

Please plan to pre-register as a group, as coordinated by a member of the NJACS DMDG Steering Committee List, below, from your organization.

  • If you have no DMDG member at your company, please contact Bo Wen (bo.1.wen@gsk.com) for registration.
  • Payments by personal or company checks. Sorry, credit cards are not accepted.
  • Checks should be made payable to: NJ Drug Metabolism Discussion Group.

Exhibitors:

  • Please contact Anima Ghosal (ghosala@aol.com) for information concerning exhibits

Program

“Translational Advances in Drug Disposition and Toxicity:
Emerging Technologies and Tools”

8:00 a.m.

Registration / Continental Breakfast / Vendor Exhibit

9:00 a.m.

Introductory Remarks

Bo Wen, Chair, NJ DMDG

9:10 a.m.

Predicting Transporter-Based Systemic and Tissue Drug Disposition Using Quantitative Proteomics and PET Imaging

Jashvant Unadkat, PhD, Professor, Department of Pharmaceutics, University of Washington, Seattle, WA

10:00 a.m.

Decoding Host-Microbe Communication Through Metabolomics

Andrew Patterson, PhD, Associate Professor, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA

10:45 a.m.

Vendor Exhibit & Coffee Break

11:30 p.m.

Drug Metabolism Enzyme and Transporter Pharmacogenetics in Drug Development: Industry Practices and Challenges

William Brian, PhD, Senior Director, Department of Translational Medicine and Early Development (TMED), Sanofi, Bridgewater, NJ

12:15 p.m.

Lunch & Vendor Exhibit

1:45 p.m.

Transporter-Mediated Asymmetric Tissues Disposition for Drug Efficacy and Toxicity: Opportunities and Challenges in Translation

Yurong Lai, PhD, Sr. Principal Scientist, Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Princeton, NJ

2:30 p.m.

Vendor Exhibit & Coffee Break

3:00 p.m.

How Can The Evolution of LC/MS Technology Enable Drug Metabolism Scientists to Continue Their Remarkable Contributions to Drug Discovery and Development?

Mingshe Zhu, PhD, Principal Scientist, Department of Biotransformation, Bristol-Myers Squibb, Princeton, NJ

3:45 p.m.

Program Closure


top

NJ-DMDG Steering Committee 2016-2017
Name Company E-mail address Responsibility
Bo Wen GSK bo.1.wen@gsk.com Chair, 2016-17
Manthena Varma Pfizer Manthena.V.Varma@pfizer.com Chair Elect, 2017-18
Zhao pie Zeng Sanofi Zhaopie.Zeng@sanofi-aventis.com Treasurer
Anima Ghosal Kean Univ ghosala@aol.com Vendor Liaison
Lauren Aleksunes Rutgers Univ aleksunes@eohsi.rutgers.edu Past Chair, 2015-16
Richard Tschirret-Guth Merck richard_tschirretguth@merck.com Past Chair, 2014-15
Wing Lam Janssen R&D wlam@its.JnJ.com Past Chair, 2013-14
Allen Jones   allen.n.jones@verizon.net Past Chair, 2012-13
Lian Zhou BMS Lian.zhou@bms.com Past Chair, 2011-12
Imad Hanna Novartis imad.hanna@novartis.com Member
Ron Kong PTC Therapeutics rkong@ptcbio.com Member
Lei Tang Sanofi Lei.Tang@sanofi-aventis.com Member
Li Yu Roche li.yu.ly1@roche.com Member
Yaofeng Cheng BMS Yaofeng.Cheng@bms.com Member
Virna Schuck Novartis virna.schuck@novartis.com Member
Naiyu Zheng BMS naiyu.zheng@bms.com Member
Beth Joshi Merck elizabeth.joshi@merck.com Member
Matthew Hoffmann Celgene mjhoffman@celgene.com Member
Karen H. Dingley Celgene kdingley@celgene.com Member
Carolina Berthiaume   carolina.berthiaume@gmail.com Member
Maria Markowska   cMmaryla5@yahoo.com Member


top

Directions to the Palace at Somerset Park

    333 Davidson Avenue, Somerset, NJ 08873
    Phone: 732-302-9922

From the New Jersey Turnpike:

    Exit 10 to Interstate 287 North.
    Follow 10 miles to Exit 10 (527 New Brunswick -- South Bound Brook).
    Take Easton Ave towards South Bound Brook to first light,
    make left (Davidson Ave.)

From New York City:

    Lincoln Tunnel to N.J. Turnpike South.
    Follow N.J. Turnpike directions mentioned above.

From Route 287:

    If traveling north:

      Exit 10 (527 New Brunswick -- South Bound Brook).
      Follow sign towards Bound Brook, to light
      make left (Davidson Ave.)
    If traveling south:

      Exit 10 (527 New Brunswick).
      Left on Easton Ave., to light,
      make left (Davidson Ave).

From Newark Airport:

    Take NJ Turnpike South to Exit 10
    I-287 North to Exit 10 (Easton Ave)
    at first light, go left on Davidson Ave.
    Hotel immediately on left.

top

✎ 2016-10-13

(Past Events)

April 14, 2016 – DMDG Spring Symposium and Vendor Exhibition

NJ-DMDG

Drug Met Symposium and Vendor Show

                [ back ]
Date:   April 14, 2016
Venue: The Palace at Somerset Park, 333 Davidson Avenue, Somerset, NJ 08873.

Mark your calendars for The North Jersey Drug Metabolism Discussion Group Spring 2016 Symposium and Vendor Exhibition, to be held at The Palace at Somerset Park, 333 Davidson Avenue, Somerset, NJ 08873, on Thursday, April 14, from 8:00-4:00 PM.

Registration Information:

Pre-registration fee is $125 (pre-register by 7 April 2016).

Registration fee at the door is $150 (Checks only)

Registration fee is $10 for students and postdocs and $50 for faculty

Registration is free for unemployed

Please plan to pre-register as a group, as coordinated by a member of the NJACS DMDG steering committee from your organization (see list).

  • If you have no DMDG member at your company, please contact Richard Lauren Aleksunes       (aleksunes@eohsi.rutgers.edu) for registration.
  • Payments by personal or company checks.  Sorry, credit cards are not accepted.
  • Checks should be made payable to: NJ Drug Metabolism Discussion Group.

Exhibitors:

2016 Spring Symposium and Vendor Exhibition

Sponsored by the

North Jersey ACS

Drug Metabolism Discussion Group

“Transforming assessment of Drug Disposition with Novel Methodologies”

The Palace at Somerset Park, 333 Davidson Avenue Somerset, New Jersey

14 April, 2016 8:00 am – 4:00 pm

Program

“Transforming assessment of Drug Disposition with Novel Methodologies”

8:00 a.m.

Registration / Continental Breakfast / Vendor Exhibit

9:00 a.m.

Introductory Remarks

Lauren Aleksunes, Chair, NJDMDG

9:10 a.m.

Topic:  Application of Engineered Mouse Models for Xenobiotic Disposition Studies

Xinxin Ding, SUNY Polytechnic Institute

10:00 a.m.

Topic:  Challenges in Identifying Biomarkers for Transporter-Mediated Drug-Drug Interactions in Liver and Kidney

Raymond Evers, Merck & Co.

10:45 a.m.

Vendor Exhibit & Coffee Break

11:30 p.m.

Topic: Microsampling in Nonclinical Studies: Where are We Now?

Laura Patrone, Bristol-Myers Squibb

12:15 p.m.

Lunch & Vendor Exhibit

1:45 p.m.

Topic: MALDI Imaging MS: Seeing Drug ADME in Tissues at Last

Stephen Castellino, GlaxoSmithKline

2:30 p.m.

Vendor Exhibit & Coffee Break

3:00 p.m.

Topic: Validation of an Integrated Series of Ligand Binding Assays for the Quantitative Determination of Antibody Drug Conjugates in Biological Matrices

Heather Myler, Bristol-Myers Squibb

3:45 p.m.

Program Closure

 

 

✎ 2016-04-14

(Past Events)

October 15, 2015 – DMDG Spring Symposium and Vendor Exhibition

NJ-DMDG

Drug Met Symposium and Vendor Show

                [ back ]
Date:   October 15, 2015
Venue: The Palace at Somerset Park, 333 Davidson Avenue, Somerset, NJ 08873.

Mark your calendars for The North Jersey Drug Metabolism Discussion Group Spring 2015 Symposium and Vendor Exhibition, to be held at The Palace at Somerset Park, 333 Davidson Avenue, Somerset, NJ 08873, on Monday, October 15, from 8:00-4:00 PM.

Registration Information:

Pre-registration fee is $125 (pre-register by 15 October 2015).

Registration fee at the door is $150 (Checks only)

Registration fee is $10 for students and postdocs and $50 for faculty

Registration is free for unemployed

Please plan to pre-register as a group, as coordinated by a member of the NJACS DMDG steering committee from your organization (see list).

·         If you have no DMDG member at your company, please contact Richard Tschirret-Guth       (richard_tschirretguth@merck.com) for registration.

·         Payments by personal or company checks.  Sorry, credit cards are not accepted.

·         Checks should be made payable to: NJ Drug Metabolism Discussion Group.

Exhibitors:

·         Please contact Karen Dingley (karen_dingley@merck.com) for information concerning exhibits

2015 Fall Symposium and Vendor Exhibition

Sponsored by the

North Jersey ACS

Drug Metabolism Discussion Group

“Strategies to Predict and Reduce Drug Interactions and Toxicities”

The Palace at Somerset Park 333 Davidson Avenue Somerset, New Jersey 15 October, 2015 8:00 am – 3:45 pm

Program

“Recent Advances in Drug Distribution and Drug Action”

8:00 a.m.

Registration / Continental Breakfast / Vendor Exhibit

9:00 a.m.

Introductory Remarks

Richard Tschirret-Guth, Chair, NJDMDG

9:10 a.m.

Topic:  Identifying Strategies to Prevent Antiretroviral Drug-induced Toxicities

Namandje Bumpus, Johns Hopkins School of Medicine

10:00 a.m.

Topic:  Targeted Pharmacological Control of the Microbiome to Improve Human Health

Matthew Redinbo, University of North Carolina at Chapel Hill

10:45 a.m.

Vendor Exhibit & Coffee Break

11:30 p.m.

Topic: Toxicity Prediction and Development of Pharmacogenetic Co-Diagnostics Using Diversity Outbred Mice

Alison Harrill, University of Arkansas for Medical Sciences

12:15 p.m.

Lunch & Vendor Exhibit

1:45 p.m.

Topic: Renal Drug Interactions: Progress and Challenges in Making Predictions in a Complex System

Adrian Ray, Gilead Sciences

2:30 p.m.

Vendor Exhibit & Coffee Break

3:00 p.m.

Topic: Cynomolgus Monkey as a Potential Model to Assess Drug Interactions involving Hepatic OATP Transporters: In Vitro, In Vivo, and In Vitro-to-In Vivo Extrapolation

Hong Shen, Bristol-Myers Squibb

3:45 p.m.

Program Closure

 

 

✎ 2015-10-15

(Past Events)

April 27, 2015 – DMDG Spring Symposium and Vendor Exhibition

NJ-DMDG

Drug Met Symposium and Vendor Show

                [ back ]
Date:   April 27, 2015
Venue: The Palace at Somerset Park, 333 Davidson Avenue, Somerset, NJ 08873.

Mark your calendars for The North Jersey Drug Metabolism Discussion Group Spring 2015 Symposium and Vendor Exhibition, to be held at The Palace at Somerset Park, 333 Davidson Avenue, Somerset, NJ 08873, on Monday, April 27, from 8:00-4:00 PM.

Registration Information:

Pre-registration fee is $125 (pre-register by 17 April 2015).

Registration fee at the door is $150 (Checks only)

Registration fee is $10 for students and postdocs and $50 for faculty

Registration is free for unemployed

Please plan to pre-register as a group, as coordinated by a member of the NJACS DMDG steering committee from your organization (see list).

·         If you have no DMDG member at your company, please contact Richard Tschirret-Guth       (richard_tschirretguth@merck.com) for registration.

·         Payments by personal or company checks.  Sorry, credit cards are not accepted.

·         Checks should be made payable to: NJ Drug Metabolism Discussion Group.

Exhibitors:

·         Please contact Karen Dingley (karen_dingley@merck.com) for information concerning exhibits

2015 Spring Symposium and Vendor Exhibition

Sponsored by the

North Jersey ACS

Drug Metabolism Discussion Group

“Recent Advances in Drug Distribution and Drug Action”

The Palace at Somerset Park 333 Davidson Avenue Somerset, New Jersey 27 April, 2015 8:00 am – 3:45 pm

Program

“Recent Advances in Drug Distribution and Drug Action”

8:00 a.m.

Registration / Continental Breakfast / Vendor Exhibit

9:00 a.m.

Introductory Remarks

Richard Tschirret-Guth, Chair, NJDMDG

9:10 a.m.

Topic:  Prediction of unbound intracellular drug concentration in the presence of transporters: from in vitro to in vivo

Kenneth Korzekwa, PhD, Associate Professor Department of Pharmaceutical Sciences, School of Pharmacy, Temple University, Philadelphia, PA

10:00 a.m.

Topic:  Single cell pharmcokinetics

Greg Thurber, PhD, Assistant Professor, Department of Chemical Engineering, University of Michigan, Ann Arbor, MI  

10:45 a.m.

Vendor Exhibit & Coffee Break

11:30 p.m.

Topic: Imaging drug distribution and biomarker response in drug discovery

Paul J. McCracken, PhD, Director of Imaging, biomarkers and Personalized Medicine CFU, Eisai Product Creation Systems, Andover, MA

12:15 p.m.

Lunch & Vendor Exhibit

1:45 p.m.

Topic: Biomarkers identification/analysis in clinical research

Steven P. Piccoli, Ph.D. Research Fellow, Immunochemistry and Biomarker Development, Bristol-Myers Squibb, Princeton, NJ

2:30 p.m.

Vendor Exhibit & Coffee Break

3:00 p.m.

Topic: Systems pharmacology approach to drug disposition and action

James M. Gallo, PhD, Professor, Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY

3:45 p.m.

Program Closure

 

 

✎ 2015-04-27

(Past Events)

October 13, 2014 – DMDG Fall Symposium and Vendor Exhibition

NJ-DMDG

Drug Met Symposium and Vendor Show

                [ back ]

Date:   Oct 13, 2014 — 8:00 am – 4:00 pm
Venue: The Palace at Somerset Park, 333 Davidson Avenue, Somerset, NJ 08873.

Mark your calendars for the The North Jersey Drug Metabolism Discussion Group Fall Symposium and Vendor Exhibition, to be held at The Palace at Somerset Park, 333 Davidson Avenue, Somerset, NJ 08873, on Monday, October 13, from 8:00-4:00 PM. Additional details will be posted in September.

Current DMDG Board Members:

 

  Name   Company   Email   Role

Richard Tschirret-Guth

Merck Research

richard_tschirretguth@merck.com

Chair 2014-15

Lauren Aleksunes

Rutgers University

aleksunes@eohsi.rutgers.edu

Chair-elect, 2015-16

Matthew Hoffmann

Celgene

mjhoffman@celgene.com

Treasurer

Karen H. Dingley

Merck Research

karen_dingley@merck.com

Vendor Liaison

Wing Lam

Janssen R&D

wlam@its.JnJ.com

Past-Chair, 2013-14

Allen Jones

allen.n.jones@verizon.net

Past Chair, 2012-13

Lian Zhou

BMS

Lian.zhou@bms.com

Past Chair, 2011-12

Imad Hanna

Novartis

imad.hanna@novartis.com

Past Chair, 2010-11

Roseann Affinito

KCAS Bio

roseannaffinito@optonline.net

Member

Shiying Chen

Merck Research

shiying.chen@merck.com

Member

Ron Kong

PTC Therapeutics

rkong0605@gmail.com

Member

Maria Markowska

 

Mmaryla5@yahoo.com

Member

Zhao pie Zeng

Sanofi-aventis

Zhaopie.Zeng@sanofi-aventis.com

Member

Lei Tang

Sanofi-aventis

Lei.Tang@sanofi-aventis.com

Member

Bo Wen

GSK

bo.1.wen@gsk.com

Member

Manthena Varma

Pfizer

Manthena.V.Varma@pfizer.com

Member

Li Yu

Roche

li.yu.ly1@roche.com

Member

Yaofeng Cheng

BMS

Yaofeng.Cheng@bms.com

Member

Carolina Cabral

 

cbcabral@gmail.com

Member

✎ 2014-10-13

(Past Events)

May 1, 2014 – DMDG Spring Symposium and Vendor Exhibition

NJ-DMDG

Drug Met Symposium and Vendor Show

                [ back ]

Date:   May 1, 2014
Venue: The Palace at Somerset Park, 333 Davidson Avenue, Somerset, NJ 08873.

2014 Spring Symposium and Vendor Exhibition

Sponsored by the

North Jersey ACS

Drug Metabolism Discussion Group

“Effect of gender, hepatic and renal function on the systemic clearance of small molecules/biotherapeutics and anti-HCV polypharmacy”

The Palace at Somerset Park
333 Davidson Avenue
Somerset, New Jersey
1 May, 2014
8:00 am – 3:45 pm

Program

“Effect of gender, hepatic and renal function on the systemic clearance of small molecules/biotherapeutics and anti-HCV polypharmacy”

8:00 a.m.

Registration / Continental Breakfast / Vendor Exhibit

9:00 a.m.

Introductory Remarks

Dr. Wing Lam, Chair, NJDMDG

9:10 a.m.

FXR and Liver Functions

Grace L. Guo, MBBS, PhD, Associate Professor, Department of Pharmacology and Toxicology, Ernst Mario School of Pharmacy, the Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ

10:00 a.m.

The Clearance of Drugs and Biologics in Human Models of Kidney Disease

Melanie S. Joy, PharmD, PhD, FCCP, FASN, Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO  

10:45 a.m.

Vendor Exhibit & Coffee Break

11:30 p.m.

Hypnotic Drugs, Gender, and the FDA

David J. Greenblatt, MD, Professor of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine and Tufts Medical Center,
Boston, MA

12:15 p.m.

Lunch & Vendor Exhibit

1:45 p.m.

Quantitative Pharmacology in Biotherapeutics Development

Honghui Zhou, PhD, Senior Director and Janssen Fellow, Head, Pharmacokinetics and Pharmacodynamics, Biologics Clinical Pharmacology, Biotechnology CoE, Janssen Research & Development, LLC., Spring House, PA  

2:30 p.m.

Vendor Exhibit & Coffee Break

3:00 p.m.

The Clinical Pharmacology of Anti-HCV Agents

Steven J. Kovacs, PharmD, Director, Translational Medicine, Novartis Institutes for Biomedical Research , East Hanover, NJ

3:45 p.m.

Program Closure

 

2013 DMDG Board Members:

 

  Name   Company   Email   Role

Wing Lam

Janssen R&D

wlam@its.JnJ.com

Chair, 2013-14

Richard Tschirret-Guth

Merck Research

richard_tschirretguth@merck.com

Chair-elect 2014-15

Matthew Hoffmann

Celgene

mjhoffman@celgene.com

Treasurer

Karen H. Dingley

Merck Research

karen_dingley@merck.com

Vendor Liaison

Allen Jones

Alliance Technologies

allen.n.jones@verizon.net

Past Chair, 2012-13

Lian Zhou

BMS

Lian.zhou@bms.com

Past Chair, 2011-12

Imad Hanna

Novartis

imad.hanna@novartis.com

Past Chair, 2010-11

Roseann Affinito

KCAS Bio

roseannaffinito@optonline.net

Member

Lauren Aleksunes

Rutgers University

aleksunes@eohsi.rutgers.edu

Member

Shiying Chen

Merck Research

shiying.chen@merck.com

Member

Karl Frank

 

kbfrank3@verizon.net

Member

Ron Kong

PTC Therapeutics

rkong0605@gmail.com

Member

Maria Markowska

 

Mmaryla5@yahoo.com

Member

Zhao pie Zeng

Sanofi-aventis

Zhaopie.Zeng@sanofi-aventis.com

Member

Lei Tang

Sanofi-aventis

Lei.Tang@sanofi-aventis.com

Member

Richard Tschirret-Guth

Merck Research

richard_tschirretguth@merck.com

Member

Bo Wen

GSK

bo.1.wen@gsk.com

Member

Manthena Varma

Pfizer

Manthena.V.Varma@pfizer.com

Member

Li Yu

Roche

li.yu.ly1@roche.com

Member

Yaofeng Cheng

BMS

Yaofeng.Cheng@bms.com

Member

Carolina Cabral

 

cbcabral@gmail.com

Member

 

 

✎ 2014-05-01

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