NJ Mass Spectrometry Discussion Group Monthly Meeting

Somerville Elks Lodge 1068 375 Union Avenue, Bridgewater, United States

The NJ Mass Spectrometry Discussion Group is pleased to announce our May 2, 2024 in-person Meeting. 5:30 PM    Social and Registration 6:15 PM    Complimentary Dinner 6:55 PM    Welcome and Opening Remarks 7:05 PM  Speaker 1:   Kallol Gupta, Nanobiology Institute, Yale University, and Department of Cell Biology, Yale School of Medicine, A nanoscale spatially resolved mass spectrometry-based platform for macromolecular cartography of the cellular membrane 8:00 PM Speaker 2:   Jared B. Shaw, Department of Chemistry, University of Nebraska-Lincoln;  New approaches for top-down and native top-down protein characterization Sponsored by NJACS MSDG with partial funding from ASMS Somerville Elks Lodge 1068 375 Union Avenue Bridgewater, 08807 United States+ Google Map View Venue Website

Free

NMR Seminar: Probing Molecular Packing of Lipid Nanoparticles from 31P Solution and Solid-State NMR

MS Teams

Speaker: Ryan Schroder , Senior Scientist, Bristol Myers Squibb Date: Thursday May 23rd, 2024 Time: 12:00 pm ET via Microsoft Teams Abstract Lipid nanoparticles (LNPs) are intricate multicomponent systems widely recognized for their efficient delivery of oligonucleotide cargo to host cells. Gaining insights into the molecular properties of LNPs is crucial for their effective design and characterization. However, analysis of their internal structure at the molecular level presents a significant challenge. This study introduces31P nuclear magnetic resonance (NMR) methods to acquire structural and dynamic information about the phospholipid envelope of LNPs. Specifically, we demonstrate that the31P chemical shift anisotropy (CSA) parameters serve as a sensitive indicator of the molecular assembly of distearoylphosphatidylcholine (DSPC) lipids within the particles. An analytical protocol for measuring31P CSA is developed, which can be implemented using either solution NMR or solid-state NMR, offering wide accessibility and adaptability. The capability of this method is demonstrated using both model DSPC liposomes and real-world pharmaceutical LNP formulations. Furthermore, our method can be employed to investigate the impact of formulation processes and composition on the assembly of specifically LNP particles or, more generally, phospholipid-based delivery systems. This makes it an indispensable tool for evaluating critical pharmaceutical properties such as structural

North Jersey ACS Woman’s Chemists Committee Virtual Meeting

Google Meet

The North Jersey ACS’ Women Chemists Committee is proud to present Juliet (Chin) Hart, CEOand Founder of Hart & Chin, speaking on "Being a Leader in the Sciences". Using a virtual meeting platform, Google Meet, this professional development event will address the following questions: What does it mean to be a leader in the sciences? Why would I or anyone want to be an influential leader? What are the challenges & benefits? How do I become a leader or a strong leader? Attendance is FREE and open to all via Google Meet Click here to join

MARM 2024

Pennsylvania State University University Park, PA, United States

The Central Pennsylvania Section of the American Chemical Society welcomes you to beautiful Happy Valley, home of the Penn State Nittany Lions, for the 52nd annual Mid-Atlantic Regional Meeting (MARM)!

ResMed: Residential School on Medicinal Chemistry and Biology in Drug Discovery

Hanover Marriott, Whippany, NJ 1401 NJ-10 E, Whippany, NJ, United States

ResMed is a week-long graduate level course organized to provide an accelerated program for medicinal chemists, biologists and other industrial and academic scientists who wish to broaden their knowledge of drug discovery and development. The School’s aim is to concentrate on the fundamentals that are useful in drug discovery spanning initial target validation through development.

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