NJ Mass Spectrometry Discussion Group Monthly Meeting

Somerville Elks Lodge 1068 375 Union Avenue, Bridgewater, United States

The NJ Mass Spectrometry Discussion Group is pleased to announce our April 9 2024 in-person Meeting. Program 5:30 PM    Social and Registration 6:15 PM    Complimentary Dinner 6:55 PM    Welcome and Opening Remarks 7:05 PM  Speaker 1: Darshit Shah, HLA-peptide discovery to develop tumor-specific immunotherapies for the treatment of cancer. Regeneron Pharmaceuticals 8:00 PM Speaker 2: Shourjo Ghose, Ultra-high sensitive Single Cell Proteomics on the timsTOF Ultra Attendance if Free Sponsored by Bruker 

Free

2024 Spring Symposium and Vendor Exhibition (Drug Metabolism Discussion Group )

The Palace at Somerset Park 333 Davidson Ave, Somerset, NJ, United States

Discovery, Development, and Regulatory Strategy for Biologics and ADCs in Oncology and Immunology Program 8:00 a.m. Registration / Continental Breakfast / Vendor Exhibit 8:45 a.m. Introductory Remarks Arian Emami Riedmaier, PhD; Chair, NJ DMDG 9:00 a.m. The Evolution of First-in-Human Dose Selection for Biologics in Oncology and Beyond Haiqing Wang, PhD; Senior Director, DMPK, Alnylam 9:45 a.m. Mutants, Loners and Bad Influences (Systems Model of KRAS Pathway Describing Mechanism of Response in G13D CRC) Edward Stites, MD, PhD; Associate Professor of Laboratory Medicine and Pathology, Yale School of Medicine 10:30 a.m. Vendor Exhibit & Coffee Break 11:15 a.m. Mitochondrial Bioenergetic Health Index as a Biomarker for Kidney Injury Kiran Deshpande; PhD Candidate, Ernest Mario School of Pharmacy Rutgers, New Brunswick, NJ 11:45 p.m. Vendor Exhibit & Lunch 12:45 p.m. Immunogenicity Risk Assessments and Bioanalytical Strategy for IND Enabling Studies for Complex Biologics Sanjay Dholakiya, PhD; Principal Scientist, BMS 1:30 p.m. Developing Effective Drug Development Strategies for Biologics Samuel Chuang, PhD; Senior Director, Scientific Advisory Services, Charles River 2:15 p.m. Vendor Exhibit & Coffee Break 2:30 p.m. ADCs as Therapeutic Options: History, Resurgence and DXd Based ADCs from DSI Tushar Garimella, PhD; Executive Director, Clinical Pharmacology, Daiichi-Sankyo 3:15 p.m. Medicilon Strategy

$10.00 – $150.00

2023 Baekeland Award Symposium

Lenfell Hall, Mansion (Hennessy Hall), Fairleigh Dickinson University Florham campus, Madison, NJ 285 Madison Avenue, Madison, NJ, United States

The 2023 Baekeland Award Symposium will be held in honor of Prof. Keary M. Engle (The Scripps Research Institute) on April 12, 2024 at Fairleigh Dickinson University in Madison, New Jersey. Dr. Engle will be celebrated for his novel catalytic alkene functionalization reactions, inventing general and versatile strategies for the programmed functionalization of olefins and developing nickel and palladium catalysts that are widely used in academic and industrial research labs around the world. The speakers of the symposium include Dr. Steven Wisniewski (Bristol-Myers Squibb), Tianning Diao (New York University), Peng Liu (University of Pittsburgh), and Scott Miller (Yale University). Detailed program and agenda to follow. Keary Engle -- Photo by Don Boomer The title of his talk will be "Metal–olefin interactions and the catalytic chemistry they inspire" Abstract & Bio Please see the flyer for the schedule and other information.  Please register on the right. Please note:  Registration is extended until Friday, April 12th morning. Schedule 1:00  Registration 1:30  Welcome Address Dr. Dorothy J. Phillips, ACS President-Elect Dr. Sandra Keyser, NJ-ACS & Baekeland Symposium Chair 1:45  Dr. Steven Wisniewski How Base Metals Catalysis Can Impact Process Chemistry 2:25  Dr. Tianning Diao Leveraging One- and Two-Electron Mechanisms in Nickel-Catalyzed

Free – $15.00

NMR Seminar: Adopting NMR spectroscopy to address the dynamic aspects of G protein-coupled receptor (GPCR) activation

MS Teams

Abstract X-ray crystallography and cryo-EM have established a detailed picture of the G protein-coupled receptor (GPCR) structural landscape – laying the foundation for understanding receptor activation in terms of the induced fit and conformational selection models of allostery. Yet, in many instances these conceptualizations remain unsatisfactory for explaining the molecular mechanisms of partial agonists, allosteric modulators and biased agonists. The dynamically-driven model of allostery posits that fluctuations about the mean conformation, which do not produce structural changes on a scale observable by cryo-EM and X-ray crystallography, are sufficient to lower the energy barrier between inactive and active modes. NMR can report on entropically-driven allosteric mechanisms; yet, technical challenges have largely limited its application to the super-microsecond motional regimes of GPCRs. Focusing on a thermostabilized peptide-binding GPCR, the neurotensin receptor 1 (NTS1), we employed NMR and density functional theory (DFT) to probe global sub-microsecond motions of 13Cε-methionines. Using this approach, we establish that the NTS1 solution ensemble includes substates with lifetimes on several discrete timescales. The longest-lived metastable states reflect those captured in agonist- and inverse agonist-bound crystal structures separated by large energy barriers. Individual methionine residues, some distributed up to 32 Å apart, also sense rapid motions superimposed within these

NJ Mass Spectrometry Discussion Group Monthly Meeting

Somerville Elks Lodge 1068 375 Union Avenue, Bridgewater, United States

The NJ Mass Spectrometry Discussion Group is pleased to announce our May 2, 2024 in-person Meeting. 5:30 PM    Social and Registration 6:15 PM    Complimentary Dinner 6:55 PM    Welcome and Opening Remarks 7:05 PM  Speaker 1:   Kallol Gupta, Nanobiology Institute, Yale University, and Department of Cell Biology, Yale School of Medicine, A nanoscale spatially resolved mass spectrometry-based platform for macromolecular cartography of the cellular membrane 8:00 PM Speaker 2:   Jared B. Shaw, Department of Chemistry, University of Nebraska-Lincoln;  New approaches for top-down and native top-down protein characterization Sponsored by NJACS MSDG with partial funding from ASMS Somerville Elks Lodge 1068 375 Union Avenue Bridgewater, 08807 United States+ Google Map View Venue Website

Free

NMR Seminar: Probing Molecular Packing of Lipid Nanoparticles from 31P Solution and Solid-State NMR

MS Teams

Speaker: Ryan Schroder , Senior Scientist, Bristol Myers Squibb Date: Thursday May 23rd, 2024 Time: 12:00 pm ET via Microsoft Teams Abstract Lipid nanoparticles (LNPs) are intricate multicomponent systems widely recognized for their efficient delivery of oligonucleotide cargo to host cells. Gaining insights into the molecular properties of LNPs is crucial for their effective design and characterization. However, analysis of their internal structure at the molecular level presents a significant challenge. This study introduces31P nuclear magnetic resonance (NMR) methods to acquire structural and dynamic information about the phospholipid envelope of LNPs. Specifically, we demonstrate that the31P chemical shift anisotropy (CSA) parameters serve as a sensitive indicator of the molecular assembly of distearoylphosphatidylcholine (DSPC) lipids within the particles. An analytical protocol for measuring31P CSA is developed, which can be implemented using either solution NMR or solid-state NMR, offering wide accessibility and adaptability. The capability of this method is demonstrated using both model DSPC liposomes and real-world pharmaceutical LNP formulations. Furthermore, our method can be employed to investigate the impact of formulation processes and composition on the assembly of specifically LNP particles or, more generally, phospholipid-based delivery systems. This makes it an indispensable tool for evaluating critical pharmaceutical properties such as structural

North Jersey ACS Woman’s Chemists Committee Virtual Meeting

Google Meet

The North Jersey ACS’ Women Chemists Committee is proud to present Juliet (Chin) Hart, CEOand Founder of Hart & Chin, speaking on "Being a Leader in the Sciences". Using a virtual meeting platform, Google Meet, this professional development event will address the following questions: What does it mean to be a leader in the sciences? Why would I or anyone want to be an influential leader? What are the challenges & benefits? How do I become a leader or a strong leader? Attendance is FREE and open to all via Google Meet Click here to join

MARM 2024

Pennsylvania State University University Park, PA, United States

The Central Pennsylvania Section of the American Chemical Society welcomes you to beautiful Happy Valley, home of the Penn State Nittany Lions, for the 52nd annual Mid-Atlantic Regional Meeting (MARM)!

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