Call for nominations: Award For Creativity in Molecular Design & Synthesis due Feb 29

The ACS North Jersey Section is soliciting nominations for the 2024 Award for Creativity in Molecular Design & Synthesis. The award recognizes initiative, creativity, leadership, and perseverance in pure and/or applied chemistry. Nominees must have had broad impact in the areas of chemical synthesis, method development, bioorganic/medicinal chemistry, pharmaceutical sciences, and/or molecular recognition. Nominations should include a letter describing the nominee’s achievements, a brief biography and curriculum vitae, and a list of the nominee’s important published works. Supporting letters are strongly encouraged. Please  submit  materials  by  February 29  to Professor Joseph Badillo: The prize consists of a crystal plaque and a $5,000 honorarium.

NMR Seminar: Structural Determination of Neurodegenerative Disease-Associated Proteins Inside Cells

MS Teams

 Abstract The misfolded proteins associated with neurodegenerative disease can adopt a variety of different conformations, some of which are toxic. Because these proteins have identical amino acid sequences, the cellular environment clearly influences the final state, yet most structural studies do not include the cellular context and, perhaps because we are not studying the correct conformation, not a single therapeutic strategy for these diseases addresses the underlying protein misfolding pathology. Using new sensitivity-enhancement technology for solid state NMR spectroscopy, Dynamic Nuclear Polarization, we study protein structure in native environments -inside living cells -to reveal how both healthy and disease-relevant cellular environments influence protein structure. Because NMR reports quantitatively, with atomic level precision, on all sampled conformation, it can not only report on structural polymorphs but also provide experimental restraints on regions of intrinsic disorder, complementing insights from cryo-electron microscopy and tomography.Using this approach, we recently demonstrated that an amyloid fibril with a solved cryo-EM structure was polymorphic and found that when those fibrils were used to seed amyloid propagation in mammalian cells, the minority polymorph in the purified setting became the majority polymorph inside cells. With this approach we can understand the mechanism of protein-based inheritance of amyloid aggregates and

Meeting of the Princeton ACS Section:“1D Lepidocrocite Titania-based Nanomaterials, Their Diverse Morphologies and Exceptional Properties”

Frick Chemistry Laboratory, Taylor Auditorium, Princeton University

Meeting of the Princeton ACS Section Tuesday, March 12, 2024 Professor Michel. W. Barsoum Drexel University, Philadelphia, PA “1D Lepidocrocite Titania-based Nanomaterials, Their Diverse Morphologies and Exceptional Properties” Frick Chemistry Laboratory, Taylor Auditorium, Princeton University Mixer (in Atrium) 6:30 pm; Lecture 7:00 pm   Abstract: Recently, we converted 15 binary and ternary titanium carbides, nitrides, borides, phosphides, and silicides into lepidocrocite-based, one dimensional, 1D, sub-nanometer nanofilaments, NFs, ≈ 5x7 Å in cross-section by reacting them with a tetramethylammonium hydroxide, TMAH, aqueous solution at ≈ 85 °C range for tens of hours. In some cases, the conversion is 100 % precluding the need for centrifuges, filters, etc. We currently routinely make 100 g batches in a lab setting. Depending on with what and the order the reaction products are washed, the 1D NFs self-assemble into loose, spaghetti-shaped fibers, ≈ 30 nm in diameter, fully inorganic TiO2 gels, pseudo 2D or porous mesoscopic particles. In all cases, the fundamental building block is 1D lepidocrocite NFs, ≈ 3 nm long, that self-assemble into the aforementioned morphologies. At this time, we believe that our materials are the only thermodynamically stable 1D NFs in water, with important implications in photo- and chemical catalysis. The production

Executive Committee Meeting

Zoom Meeting

This will be a virtual meeting held on Zoom. If you did not receive a Zoom invite, then register below and you will receive an email with the Zoom connection. Best, Sandra


NJCG: Green Chromatography Webinar

NJCG is hosting an online seminar on Thursday, March 14th, 2024, focused on "Green Chromatography". Register here.  Please find the attached flyer for more information.

NMR Seminar: POKY, The Software Suite for NMR Studies and More

MS Teams

Abstract NMR spectroscopy is a powerful technique for molecular studies. In biomolecular research, it offers a wide range of unique approaches, from analyzing small compounds to investigating macromolecules, and from examining purified samples to studying complex mixtures. NMR analysis is primarily conducted in dry laboratory settings. Once the sample is prepared and inserted into the spectrometer, nearly all processes are performed using computers. When it comes to spectral analysis of biomacromolecules, such as proteins and nucleic acids, Sparky has been the gold standard program for a few decades. Donald Kneller from the Tack Kuntz group and Tom Goddard from the Tom Ferrin group were early contributors to UCSF-Sparky in the 90s. I took over from the University of California, San Francisco (UCSF) and developed NMRFAM-Sparky at the National Magnetic Resonance Facility at Madison (NMRFAM) until 2020 before I moved to the University of Colorado Denver. Since then, my group has developed the new program, POKY. POKY succeeds all the previous capabilities while provides new and enhanced features, leveraging the recent AI revolution. It is highly automated and efficient, covering assignment, peak picking, relaxation, dynamics, metabolomics, and small compound analysis. Additionally, POKY incorporates self-teaching capabilities. We have identified six different challenges,

NJ Mass Spectrometry Discussion Group Monthly Meeting

Somerville Elks Lodge 1068 375 Union Avenue, Bridgewater, United States

The NJ Mass Spectrometry Discussion Group is pleased to announce our April 9 2024 in-person Meeting. Program 5:30 PM    Social and Registration 6:15 PM    Complimentary Dinner 6:55 PM    Welcome and Opening Remarks 7:05 PM  Speaker 1: Darshit Shah, HLA-peptide discovery to develop tumor-specific immunotherapies for the treatment of cancer. Regeneron Pharmaceuticals 8:00 PM Speaker 2: Shourjo Ghose, Ultra-high sensitive Single Cell Proteomics on the timsTOF Ultra Attendance if Free Sponsored by Bruker 

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