“Emerging Areas in DMPK: From CYPs and Transporters to Drug Interactions”

Somerset Crowne Plaza Hotel
110 Davidson Avenue
Somerset, New Jersey

October 6, 2011
8:00 am – 3:45 pm


08:00 am
Registration / Continental Breakfast / Vendor Exhibit

09:00 am
Introductory Remarks
Dr. Lian Zhou, Chair, NJDMDG

09:10 am
New Insights on the Interplay of Intestinal CYP3A and P-gp in Influencing Intestinal Absorption of Dual Substrates
Dr. Dhiren Thakker, Ferguson Distinguished Professor and Associate Dean, Pharmacotherapy and Experimental Therapeutics, School of Pharmacy, University of North Carolina, Chapel Hill, NC

10:00 am
Active Intestinal Drug Uptake: The Double-Edged Sword Transporters [slides (PDF)] Dr. Imad Hanna, Senior Fellow, Drug Metabolism and Pharmacokinetics, Novartis, East Hanover, NJ

10:45 am
Vendor Exhibit & Coffee Break

11:30 am
Pro-drug strategies to leverage transporters [slides (PDF)] Dr. James Polli, Professor of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD

12:15 pm
Lunch & Vendor Exhibit

01:45 pm
ADME of Biologics – What Have We Learned from Small Molecules?
Dr. Thomayant Prueksaritanont, Sr. Scientific Director, Preclinical Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck, West Point, PA Malvern, PA

02:30 pm
Vendor Exhibit & Coffee Break

03:00 pm
Assessing modeling and simulation tools and methods for predicting drug interactions caused by induction (FDA/Industry/Academia Induction Group Work Product) [slides (PDF)] Dr. Scott Obach, Senior Research Fellow, Pfizer Groton, CT

03:45 pm
Program Closure