North Jersey Section
American Chemical Society

Organic Topical Group

About the Organic Topical Group

NJACS-OTG
The NJACS Organic Chemistry Topical group brings together New Jersey's organic chemists from academia, companies and the pharmaceutical industry -- hosting regular meetings and semi-annual symposia.  [ Upcoming Symposium ]

2017 Board

Ken Fraunhoffer (Chair)
Bristol-Myers Squibb
One Squibb Drive
New Brunswick, NJ 08903
Kenneth.Fraunhoffer@bms.com
732-227-6715

Steven Silverman (Past-Chair)
Merck Research Laboratories
Rahway, NJ
steven.silverman@merck.com
742-594-1997

Michael Smith
Bristol-Myers Squibb
New Brunswick, NJ 08903
michael.smith2@bms.com
732-227-3231

Susan Zultanski
Merck Research Laboratories
Rahway, NJ
Susan_Zultanski@merck.com
732-594-3840

Yalan Xing
William Patterson University
xingy@wpunj.edu
973-720-3462

Michael Zacuto
Celgene
mzacuto@celgene.com


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Upcoming OTG Event

Nov 30, 2017 – Early Career Symposium

The Organic Topical Group's Fall 2017 Event

NJACS-OTGEarly Career Symposium

Date: Thursday, November 30, 2017
Time: Check-in & breakfast at 8:00 AM. Symposium begins at 9:20 AM
Venue: The Palace at Somerset Park
333 Davidson Ave, Somerset, NJ 08873
[ directions | register | flyer | OTG homepage | Committee ]

Presentations


Noah Burns

Prof. Noah Burns (Stanford)

Synthesis and Study of Unusual Lipids

Ke Chen

Dr. Ke Chen (Bristol-Myers Squibb)

Design and Development of the Commercial Process for a Tyk2 Inhibitor

Corinna Schindler

Professor Corinna Schindler (University of Michigan)

Iron(III)-Catalyzed Carbonyl-Olefin Metathesis

Todd Hyster

Professor Todd Hyster (Princeton)

Using Enzymes as Catalysts for Non-Natural Free Radical Reactions

Dani Schultz

Dr. Dani Schultz (Merck)

Remote Functionalization of C–H Bonds of Aliphatic Amines via Decatungstate Photocatalysis

Alex Radosevich

Professor Alex Radosevich (MIT)

Catalytic Synthetic Methods Based on P(III) ⇌ P(V) Redox Cycling

Schedule

8:00 – 9:20

Registration/breakfast/networking

9:20 – 9:30

Dr. Ken Fraunhoffer (Bristol-Myers Squibb)

Welcoming remarks

9:30 – 10:20

Professor Corinna Schindler (University of Michigan)

Iron(III)-Catalyzed Carbonyl-Olefin Metathesis

Introduced by Professor Yalan Xing, William Paterson University

10:20 – 11:10

Dr. Ke Chen (Bristol-Myers Squibb)

Design and Development of the Commercial Process for a Tyk2 Inhibitor

Introduced by Dr. Ken Fraunhoffer (Bristol-Myers Squibb)

 

11:10 – 11:40

 

AM Coffee Break

 

11:40 – 12:30

Professor Todd Hyster (Princeton University)

Using Enzymes as Catalysts for Non-Natural Free Radical Reactions

Introduced by Dr. Mike Smith (Bristol-Myers Squibb)

12:30 – 1:30

Lunch

 

1:30 – 2:20

Dr. Dani Schultz (Merck)

Remote Functionalization of C–H Bonds of Aliphatic Amines via Decatungstate Photocatalysis

Introduced by Dr. Sue Zultanski, Merck

 

2:20 – 3:10

Professor Noah Burns (Stanford University)

Synthesis and Study of Unusual Lipids

Introduced by Dr. Steve Silverman, Merck

 

3:10 – 3:40

 

PM Coffee Break

 

3:40 – 4:30

Professor Alex Radosevich (MIT)

Catalytic Synthetic Methods Based on P(III) P(V) Redox Cycling

Introduced by Dr. Mike Zacuto, Celgene

4:30-4:40

Dr. Steve Silverman (Merck)

Concluding remarks

 

Organizing Committee

  • Ken Fraunhoffer (Chair, BMS) [ email ]
  • Steve Silverman (Merck) [ email ]
  • Michael Smith (BMS) [ email ]
  • Yalan Xing, (William Paterson University) [ email ]
  • Michael Zacuto (Celgene) [ email ]
  • Sue Zultanski (Merck) [ email ]

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Registration

  • Registration fee is $120.00 (which includes symposium and lunch). Students: $45 (limited number of seats)
  • Deadline for registration and payment: November 20, 2017
    Note: Deadline is being extended -- but please sign-up right away! 
  • Please register & pay online below with a credit / debit card. Please Note: Registration and payment are two separate steps!

Pay Registration Fee

Registration Type Use any of these cards

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2017-11-30

(Past Event)

Dec 3, 2015 – Innovation in Drug Discovery 2015

The Organic Topical Group's 2015 Symposium

NJACS-OTGInnovation in Drug Discovery

Date:  Thursday, December 3, 2015
Time:  Check-in & breakfast at 8:30 AM. Symposium begins at 9:20 AM
Venue: The Palace at Somerset Park
       333 Davidson Ave, Somerset, NJ 08873
       [ directions | register | flyer | OTG homepage ]

Presentations

Nils Lonberg

Nils Lonberg (BMS)

Targeting the Immune System for Cancer Therapy

Alexander Ruchelman

Alexander Ruchelman (Celgene)

Apremilast: From Discovery to Commercialization

Mike Kress

Mike Kress (Merck)

Contemporary Process Chemistry Solutions: Good Enough is Never Good Enough

Peter Senter

Peter Senter (Seattle Genetics)

Antibody Drug Conjugates: From Preclinical Research to an Approved Drug and Beyond

Seth Herzon

Professor Seth Herzon (Yale University)

Synthetic and Translational Studies of the Diazofluorene Antitumor Antibiotics

Dennis Liotta

Dennis Liotta (Emory University)

The Role of CXCR4 Modulators in Controlling HIV Entry, Stem Cell Mobilization and Certain Types of Cancer

Program Agenda

8:30 am Breakfast and Registration
9:20 am Introductory Remarks
9:30 am Professor Dennis Liotta (Emory University)

The Role of CXCR4 Modulators in Controlling HIV Entry, Stem Cell Mobilization and Certain Types of Cancer

10:20 am Alexander Ruchelman (Celgene)

Apremilast: From Discovery to Commercialization

11:10 am Coffee Break
11:30 am Mike Kress (Merck)

Contemporary Process Chemistry Solutions: Good Enough is Never Good Enough

12:20 pm Lunch
1:10 pm Nils Lonberg (Bristol-Myers Squibb)

Targeting the Immune System for Cancer Therapy

2:00 pm Professor Seth Herzon (Yale University)

Synthetic and Translational Studies of the Diazofluorene Antitumor Antibiotics

2:50 pm Coffee break
3:10 pm Peter Senter (Seattle Genetics)

Antibody Drug Conjugates: From Preclinical Research to an Approved Drug and Beyond

4:00 pm Concluding Remarks

Organizing Committee

  • Amjad Ali, (Co-Chair, Merck) [ email ]
  • Ken Fraunhoffer (BMS) [ email ]
  • Eric Mertz (Merck) [ email ]
  • Steve Silverman (Merck) [ email ]
  • Lawrence Williams (Co-Chair, Rutgers) [ email ]
 

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Registration

  • Registration fee is $100.00 (which includes breakfast and lunch)
  • Deadline for registration and payment: November 20, 2015 Deadline extended to December 2nd
  • Please register & pay online below with a credit / debit card. Registration and payment are two separate steps.

Pay Registration Fee

Registration Type Use any of these cards

Register

Registration closed

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2015-12-03

(Past Event)

Dec 5, 2014 – Award for Creativity in Molecular Design & Synthesis

OTG 2014 Award Symposium

2014 Award Recipient – Professor David MacMillan

David_MacMillan

Professor MacMillan will be recognized “for his pioneering work in the field of enantioselective catalysis, new reaction methodology and natural product synthesis”.

Venue: West Auditorium Robert Wood Johnson Medical School 675 Hoes Lane West-Piscataway, NJ [ Directions ]

park In Lots 54, 54A 58 & 58A without permits

Date:     Friday, December 5, 2014

Times:  12:00 PM – Registration

12:30 PM – Symposium

Please distribute this [ Flyer ]

Student Poster Session-complimentary admission for presenters [ call for abstracts ]. Deadline extended to Dec. 1st
Advance registration required: [ register here ]
Registration fee: $20, Students $10 [ pay online here ]
[ photos ]

Speakers

  • Prof. Stephen Buchwald (MIT)
  • Prof. Paul Reider (Princeton Univ)
  • Prof. Rob Knowles (Princeton Univ)
  • Prof. Gary Molander (U. Penn)
  • Prof. David MacMillan (Princeton Univ)

Sponsors

Merck

Wuxi AppTec

Agilent Technologies

Program

12:00–12:30 Registration
12:30–12:40 Welcome Address: Dr. Ron Kong, Symposium Chair
12:40–1:30 Prof. Gary A. Molander (U. Penn)

Novel Mechanistic Paradigm for Organoboron Cross-Coupling

1:30–2:20 Prof.  Paul Reider (Princeton U.) Chemistry in Service to Society:  

35 Years of Success and Failure Bringing New Medicines to the Patients Who Need Them 

2:20–3:10 Prof. Rob Knowles (Princeton U.)

Proton-Coupled Electron Transfer in Organic Synthesis and Asymmetric Catalysis

3:10–3:40 Break / Refreshments
3:40–4:30 Prof. Stephen Buchwald (MIT)

Metal-Catalyzed Transformations in Organic Chemistry

4:30–4:40 Award Presentation (Dr. Monica Sekharan, NJ-ACS Chair)
4:40–5:30 Keynote: Prof. David MacMillan (Princeton U.)

Photoredox Catalysis: New Reactions of Value to Medicinal and Process Chemistry

5:30 Closing remarks: Dr. Les McQuire, NJACS Awards Chair

Retrospective of the 2014 Symposium

TDavid MacMillanhe 2014 Award for Creativity in Molecular Design and Synthesis was presented to Professor David MacMillan, James S. McDonnell Distinguished University Chair and Professor of Chemistry at Princeton University, at a symposium held at the Robert Wood Johnson Medical School, Rutgers University in Piscataway, NJ on December 6th.  More than 130 industrial chemists, students, and faculty from North Jersey and surrounding sections attended.  Dr. MacMillan was recognized for his “initiative, creativity, leadership, and perseverance in pure and/or applied chemistry.”

In his keynote address, Professor MacMillan described his lab’s cutting-edge research on photoredox catalysis to organic synthesis.  Its implementation has led to the discovery of a myriad of individual reactions. Other speakers included Stephen Buchwald, Camille Dreyfus Professor of Chemistry at Massachusetts Institute of Technology, whose research combines elements of organic chemistry, organic synthesis, and organometallic chemistry to devise catalytic processes;  Rob Knowles, Professor of Chemistry at Princeton University, whose research focuses on synthetic applications of proton-coupled electron transfer (PCET) reactions; Gary A. Molander, Hirschman Makineni Professor and Chair at the University of Pennsylvania, whose research interests are in the development of new synthetic methods for organic synthesis; and, Paul J. Reider, Teaching Professor at Princeton University, where his research is focused on new drugs for Malaria, TB and other neglected diseases.

Dr. Ronald Kong,  Award Chair and Chair-elect of the North Jersey Section, welcomed the guests and described the award.  Dr. Monica Sekharan, Section Chair presented the award plaque and honorarium to Professor MacMillan.  Dr. Les McQuire, NJ-ACS Awards Chair gave the closing remarks and invited attendees to send him names of NJACS members who deserve recognition for their scientific accomplishments and volunteerism.

Awardees are acknowledged for their broad impact in the areas of chemical synthesis, method development, bioorganic/medicinal chemistry, pharmaceutical sciences, and/or molecular recognition.  Visit the North Jersey Section’s website, www.njacs.org, for more details.

NJACS is grateful to the sponsors of this event – Merck, WuXi AppTec, Agilent Technologies, and Rutgers University.

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1. Prof David MacMillan and Dr Monica Sekharan (Chair NJACS)
1. Prof David MacMillan and Dr Monica Sekharan (Chair NJACS)
2. Rob Knowles, Dave MacMillan, Gary Molander, Paul Reider, Stephen Buchwald
2. Rob Knowles, Dave MacMillan, Gary Molander, Paul Reider, Stephen Buchwald
3. Prof MacMillan, Speakers, Committee. Back: B Suits, B Howson, A Ali, D Krone, M Sekharan. Front: E Mertz, R Kong, R Knowles, D MacMillan, G Molander, P Reider, S Buchwald, A Cooper, L McQuire
3. Prof MacMillan, Speakers, Committee. Back: B Suits, B Howson, A Ali, D Krone, M Sekharan. Front: E Mertz, R Kong, R Knowles, D MacMillan, G Molander, P Reider, S Buchwald, A Cooper, L McQuire
4. Rob Knowles, Gary Molander, Paul Reider, Stephen Buchwald, Jean Kim (Mrs. MacMillan) and David MacMillan
4. Rob Knowles, Gary Molander, Paul Reider, Stephen Buchwald, Jean Kim (Mrs. MacMillan) and David MacMillan

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2014-12-05

(Past Event)

Nov 14, 2012 – The 2012 Award for Creativity in Molecular Design & Synthesis

2012 Award Recipient: Prof. K.C. Nicolaou
The Scripps Research Institute and the University of California, San Diego

Venue: The Palace at Somerset Park, 333 Davidson Ave, Somerset, NJ 08873
Click here for: Directions | Flyer | Registration | Pay Registration Fee

Date: Held on Wednesday, November 14, 2012

Program & Registration Fee
8:00 am Sign-in begins
9:00 am – 5:00 pm Symposium
12:00 pm Lunch

Symposium (including banquet lunch): $80.00
Students: $35.00 (limited number of seats)
You may pay online below.

Due to limited seating, registration and payment are required by November 5, 2012.


The North Jersey ACS Organic Topical Group Congratulates Professor K.C. Nicolaou on his receipt of the 2012 Award for Creativity in Molecular Design and Synthesis!


The members of the North Jersey ACS OTG thank all of the speakers, attendees and corporate sponsors for helping to make this year’s award symposium a success! Left to right: Professor Lawrence Williams (Rutgers), Professor Daniel Seidel (Rutgers), Professor K.C. Nicolaou (Scripps), Dr. Akin Davulcu (BMS), Dr. Amjad Ali (Merck), Dr. Michael Miller (BMS), Dr. Naresh Jain (TCRS-US), Dr. Steven Silverman (BMS)

Invited Speakers

Prof. Erik J. Sorensen
Princeton University
“Taking Risks in Complex Synthesis Design”

Prof. Scott A. Snyder
Columbia University
“Exploring Chemoselectivity through Natural Products Total Synthesis”

Dr. Janet Gunzner-Toste
Genentech, Inc.
“The Discovery and Development of Erivedge”

Prof. Phil S. Baran
Scripps Research Institute, Skaggs Institute for Chemical Biology
“Studies in Natural Product Synthesis”

Professor K.C. Nicolaou
The Scripps Research Institute and The University of California, San Diego
“Total Synthesis of Natural Products of Biological and Medicinal Importance”

Organizing Committee

  • Akin Davulcu (Chair, BMS)
  • Daniel Seidel (Past Chair, Rutgers)
  • Amjad Ali (Merck)
  • Steven Silverman (BMS)
  • Joe Kozlowski (Merck)

2012-11-14

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