Abstract: Drug Discovery and Pharmaceutical Development are driven by the need for the rapid advancement of potential drug candidates while the time available for research and development is concurrently pressured to decrease. A direct consequence of these accelerated time lines is increased demand on spectroscopic support groups to provide the same structural elucidation data historically available to the organic chemist while using smaller samples and less time, and without any loss in quality or confidence. NMR spectroscopy is routinely applied as a primary structural tool, but it is notoriously insensitive. Recent advances made in probe designs, however, have had a profound impact on sample size requirements for typical NMR analyses and on the flexibility of the NMR systems, allowing a significant increase in the efficiency of data collection by NMR.

Our presentation will focus on recently released probe designs and their applicability to pharmaceutical analysis.