North Jersey Section
American Chemical Society

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Upcoming MSDG Event

Dec 4, 2018 – MSDG Meeting

NJ-ACS Mass Spec Discussion Group
The NJ Mass Spectrometry Discussion Group is pleased to announce our December 2018 Monthly Meeting.

NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:    Tuesday December 4, 2018

Venue:   Somerville Elks Lodge 1068

     375 Union Avenue, Bridgewater, NJ 08807

     (908)707-1545

Sponsor: Shimadzu

Shimadzu

Please  register here.  Registration is free, compliments to our sponsor.

Program

5:30 PM    Social and Registration  
6:15 PM    Complimentary Dinner
6:55 PM    Welcome and Opening Remarks
7:05 PM    Speakers

Speaker 1:  Jun Zhang

Principal Scientist, Bristol-Myers Squibb

“Evaluation of Microflow LC-MS/MS in a Quantitative Discovery Bioanalysis Setting”

Abstract for Jun Zhang:

Despite recent advances made in discovery bioanalysis to address the requirements of high throughput, high capacity and fast turnaround using LC-MS/MS, challenges in sensitivity remain for the analyses of some small molecules, peptides and other modalities. In theory microflow LC-MS/MS offers increased sensitivity compared to its regular flow counterpart due to more efficient MS ionization and sampling. In this study, the feasibility of using microflow LC-MS/MS for quantitative discovery bioanalysis was assessed. The evaluation demonstrated much improved sensitivity on microflow LC vs. regular flow LC for both small molecules and peptides, along with satisfactory analytical performance and robustness. The processes of method development, optimization and sample analysis on the microflow LC-MS/MS system were also shown to be straightforward. The better sensitivity enabled by microflow LC allowed for successful problem solving and method troubleshooting that was not feasible with regular flow LC in discovery bioanalysis.

Speaker 2:  Evelyn Wang; Ph.D.

Applications Scientist, Shimadzu Scientific Instruments

“Addressing the Challenges of Cell Culture Media Monitoring Through the Use of Triple Quad LCMS and TOF Analysis Techniques”

Abstract for Dr Wang:

Cell Culture monitoring can be challenging with all the contributing factors that can lead to cell line morbidity. As such the use of the proper tools while developing the monitoring technique is crucial to improve yields and cell line life. Once accomplished, the use of robust and reliable analysis tools to accurately map and develop intervention steps to increase the cell line growth and lifespan are crucial. This talk will discuss the merits of using the Shimadzu 9030 TOF platform for identification of components present as well as anomalies that may be observed from basal verses home grown cell line media and the use of the Shimadzu Triple Quad platform to routinely monitor cell line component consumption processes for accurate media monitoring. This process can then be transferred to manufacturing seamlessly through the use of C2MAP analysis using automated sample preparation followed by injection into the MS system for analysis.

2018-12-04

(Recent Event)

Oct 9, 2018 – MSDG Meeting

NJ-ACS Mass Spec Discussion Group The NJ Mass Spectrometry Discussion Group is pleased to announce our October 2018 Monthly Meeting. NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:    Tuesday, October 9, 2018

Venue:   Somerville Elks Lodge 1068

375 Union Ave Bridgewater, NJ 08807

908-707-1545

www.SomervilleElks.org

Sponsor:   Waters

Please  register here.  Registration is free, compliments of Waters.

Program

5:30 PM    Social and Registration  

6:15 PM    Complimentary Dinner

6:55 PM    Welcome and Opening Remarks

7:05 PM    Speakers

Speaker 1: Lorell Discenza

Senior Research Scientist, Bristol-Myers Squibb

“Small Molecule Bioanalysis via LC-MS/MS is Here to Stay!”

Abstract for Lorell Discenza:
Large molecules and high resolution mass spectrometers are getting all the press, but quantitative analysis of small molecules using Triple Quadrupole Mass Spectrometers in support of TK, PK and PD studies, particularly in Drug Discovery is still in high demand. To address the increasing complexity of drug targets, medicinal chemistry is taking innovative approaches in drug design, which translates into greater challenges for the Bioanalyst.

We present LC-MS/MS assay development for measuring exposures of parent compounds and their stereoisomeric metabolites as well assays for highly polar, poorly ionized compounds. And, of course, high assay sensitivity is needed in the analysis of biological matrices such as plasma, urine, whole blood, tumor, spleen and lymph nodes.

Speaker 2:  Baiba Cabovska, Ph.D.

Senior Business Development Manager, Waters Corporation

“SHRMS and migration from food and medical product contact materials”

Abstract for Dr. Cabovska:
Extractables from packaging materials are a concern to manufacturers and suppliers of containers for the regulated food and pharmaceutical industries. The food industry is most regulated in European Union where recent regulations require testing and characterization of non-intentionally added substances in food-contact materials. Pharmaceutical industry is regulated in both the United States and Europe where extractable and leachable studies are mandatory to receive an approval for drug marketing. Due to these regulations packaging material manufacturers are motivated to control and monitor their product to ensure that no potential risk exists from extractable and leachable material.

The challenge with the compounds observed in the extraction studies is their identification. The manufacturers rarely provide a complete list of all the additives in polymers used for packaging. The original ingredients can degrade or undergo chemical changes during the manufacturing process. Also there may be contaminants that the manufacturer is not even aware of.

LetM-^Rs review how HRMS is applied for testing migration or leaching from these items to meet the regulatory requirements and to protect patients and consumers.

2018-10-09

(Recent Event)

Tue Sep 18, 2018 – MSDG Vendor Show & Symposium

NJ-ACS Mass Spec Discussion Group
The NJ Mass Spectrometry Discussion Group is pleased to announce our September 2018 Annual Vendor Show and Symposium.

NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. 

Date:  Tuesday,  September 18, 2018

Venue: Somerville Elks Lodge 1068
       375 Union Avenue
       Bridgewater, NJ 08807
       908-707-1545
       www.somervilleelks.org

Please  register here.  Registration is free, compliments of our sponsors.   [ flyer ]

A limited number of free drink tickets will be provided to early attendees!

Featuring the following sponsors / vendors / collaborators on site (listed in the order of registration):

Bruker Diagenode JEOL Eutech Instruments
Scientific Instrument Services Restek SciEx Waters
908devices IonSense Shimadzu Agilent
ThermoScientific Peak Scientific PerkinElmer Eastern Analytical Symposium

Program

3:00 – 5:00 PM        Registration, Vendor Show, and Poster Session

5:00 – 5:45 PM        Prof Hui Zhang (Johns Hopkins University)

5:45 – 7:00 PM        Buffet Dinner (raffle prizes will be announced)

7:00 – 8:00 PM        Prof Jennifer Brodbelt (University of Texas at Austin)

Prof Hui Zhang

Speaker 1: Prof Hui Zhang, PhD

Director, Mass Spectrometry Core Facility, Center for Biomarker Discovery and Translation, Department of Pathology, Johns Hopkins University

“Multi-omic analysis of tumor tissues reveals a large number of glycopeptides and their association with glycosylation enzymes”

Abstract for Prof Zhang:

Many gene products exhibit extensive structural micro-heterogeneity due to an array of co-occurring post-translational modifications. These protein modifications are not synthesized with genomic template and often affect the functionality of the proteins and therefore need to be characterized in detail in order to determine their structural and functional relationships and their potential linkage with genome and proteome. Protein glycosylation plays fundamental roles in many cellular processes, and previous reports have shown dysregulation to be associated with human diseases. Here, we describe the analysis of proteins from breast cancer xenograft tissues using our recently developed software package GPQuest 2.0, revealing a large number of previously unidentified N-linked glycopeptides. More importantly, we found that using immobilized metal affinity chromatography (IMAC) technology for the enrichment of phosphopeptides had co-enriched a substantial number of sialoglycopeptides, allowing for a large-scale analysis of sialoglycopeptides in conjunction with the analysis of phosphopeptides. Collectively, combined MS/MS analyses of proteomic and phosphoproteomic datasets resulted in the identification of thousands of intact N-linked glycopeptides derived from breast cancer xenograft tissues. This analysis revealed an extensive number of glycopeptides hidden in the proteome and co-enriched in IMAC-based phosphopeptide-enriched proteomic data.

We then performed genomic, proteomic, and glycoproteomic analysis of human high-grade serous ovarian carcinoma (HGSOC) and non-cancerous tissues, we found that abundance at glycosites was regulated by the overall glycoprotein expression, while glycosylation at each individual glycosylation site contained glycosylation-site-specific heterogeneity and it was regulated by the protein abundance of the glycoproteins as well as the levels of glycosylation enzymes that were involved in the glycosylation biosynthesis pathway. This study bridges the gaps among alterations in gene and protein expression, protein glycosylation, and phosphorylation by providing the most complete landscape of glycoproteome in related to proteome and genome, which would be beneficial for stratifying other protein modifications for changes of cancer gene products based on genetic alterations. Furthermore, using the data from glycoproteomics, proteomics, and genomics, we defined and demonstrated the possibility of classifying the pathological outcome of cancer from normal tissues of HGSOC using glycans on the glycoproteins from tissues.


Prof Jenny Brodbelt

Speaker 2: Prof Jenny Brodbelt

Norman Hackerman Chair,  Department of Chemistry, University of Texas at Austin

“Ultraviolet Photodissociation Mass Spectrometry for Characterization of Proteins and Protein Complexes”

Abstract for Prof Brodbelt:

Developments in mass spectrometry instrumentation and experimental design have motivated new applications in the field of structural biology. Ultraviolet photodissociation (UVPD) results in broad sequence coverage of intact proteins via more extensive backbone fragmentation than can be obtained using other MS/MS methods, and ion activation/dissociation can be accomplished using a single 5 ns laser pulse. This translates to a compelling MS/MS technology for characterization of intact proteins, including mapping post-translational modifications and ligand binding sites. There has been growing interest in employing top-down approaches to characterize proteins and to examine native-like protein structures by using MS/MS to disassemble the complexes and sequence the constituent proteins. UVPD provides high levels of sequence coverage for native-like protein complexes, and the relative abundances of fragment ions correlate with variations in the intramolecular and intermolecular interactions that stabilize particular regions of the proteins. Products retaining non-covalently bound ligands reflect the fast, high energy activation of UVPD.  For multimeric protein complexes, UVPD disassembles the complexes to reflect sub-unit architecture.

2018-09-18

(Past Events)

Jun 19, 2018 – MSDG Meeting

NJ-ACS Mass Spec Discussion Group The NJ Mass Spectrometry Discussion Group is pleased to announce our June 2018 Monthly Meeting. NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:    Tuesday, June 19, 2018

Venue:   Somerville Elks Lodge 1068

375 Union Ave Bridgewater, NJ 08807

908-707-1545

www.SomervilleElks.org

Sponsor: Thermo Fisher

Please  register here.  Registration is free, compliments of Thermo Fisher.

Program

5:30 PM    Social and Registration  
6:15 PM    Complimentary Dinner
6:55 PM    Welcome and Opening Remarks
7:05 PM    Speakers

Speaker 1:  Scott Peterman, PhD

Sr. Manager, Global Marketing for Advanced Products, Thermo Fisher

“Breaking the Bottlenecks of Small Molecule Research Using the Thermo Scientific Orbitrap ID-X Mass Spectrometer”

Abstract for Dr. Peterman:

Small molecule research covers a very broad range of applications, but all have similar experimental objectives for identifying and characterizing the compounds of interest to evaluate the stated research objective. Similarly, all applications face bottlenecks associated with exhaustively sampling compounds of interest in the presence of the background matrix, efficiently isolating and fragmenting each compound to generate high-quality, product ion rich spectral ion trees, and confidently automating the data processing to significantly increase the conversion of unknown unknowns to knowns. This presentation will highlight the new workflows focused on small molecules with our new tribrid mass spectrometer. The workflow components enable complex methods to be easily created, employed in automated sequence analysis routines, and demonstrations of the data processing routines used for compound identification and structural elucidation, regardless of the user expertise.

Speaker 2:  Debadeep Bhattacharyya

Sr. Manager, Marketing, Clinical Research and Forensic Toxicology, Thermo Fisher

“Confident Quantitation – Addressing Today’s and Tomorrow’s Challenges”

Abstract for Dr. Bhattacharyya:

While quantitative analysis of critical analytes in different matrices has been around for several years now, the growing complications in types of analytes and complexities of matrices continue to pose challenges to every analytical scientist focused on developing quantitative workflows. This presentation will highlight the benefits of a comprehensive workflows focused on targeted quantitation with our new generation Triple Quadrupole MS platforms. These workflows enable development of robust, reliable, reproducible, quantitative workflows for every molecule type, in every matrix regardless of the user expertise.

2018-06-19

(Past Events)

May 9, 2018 – MSDG Meeting

NJ-ACS Mass Spec Discussion Group The NJ Mass Spectrometry Discussion Group is pleased to announce our May Monthly Meeting. NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:    Wednesday May 9, 2018

Venue:   Somerville Elks Lodge 1068       Note venue! 

375 Union Ave Bridgewater, NJ 08807

(908-707-1545)

Sponsor:       Bruker Daltonics

Please  register here.  Registration is free, compliments of Bruker Daltonics.

Program

5:30 PM    Social and Registration  
6:15 PM    Complimentary Dinner
6:55 PM    Welcome and Opening Remarks
7:05 PM    Speakers

Speaker 1: Prof. Leonard Foster, PhD

University of British Columbia, Vancouver, BC

“Exploring tissue-specific interactomes using PCP-SILAC”

Abstract for Dr. Foster:

An interactome describes the global organization of protein interactions within a cell. Protein correlation profiling (PCP) uses precise co-elution of two proteins as evidence that they interact. This high-throughput technique does not require overexpression or the creation of fusion proteins. We have created a SILAC mouse and used it to construct the interactomes of seven different tissues based on PCP. These data now allow us to ask several questions, including specialization of tissues at the interactome level, whether disease-causing mutations might perturb the interaction network in pathogenesis and the level of accuracy of computational predictions of interaction networks. This presentation will focus on the latest developments in interactome mapping from our laboratory.

Speaker 2:  Gary Kruppa, PhD

Vice President Proteomics, Bruker Daltonics Inc

“The timsTOF Pro Powered by PASEF: Digging Deeper into the Proteome with Record-breaking Speed, Sensitivity and Robustness”

Abstract for Dr. Kruppa:

Parallel Accumulation Serial Fragmentation (PASEF, Meier et al., JPR 2015, PMID: 26538118) for trapped ion mobility spectrometry (TIMS) quadrupole time of flight (QTOF) instruments enables 5-10X faster data-dependent acquisition of fragment ion spectra in bottom up shotgun proteomics. We have now implemented PASEF on a new instrument, the timsTOF Pro, and achieved deeper proteome coverage, as well as impressive gains in sensitivity and sample efficiency due to the 100% duty cycle and focusing of the ions in time and space provided by TIMS and the PASEF method. In this talk we will cover the principles of TIMS and PASEF and describe how these gains in speed and sensitivity are obtained. The impact of this method on instrument time and sample amount vs proteome depth in data-dependent shotgun proteomics experiments will be discussed.

2018-05-09

(Past Events)

Apr 10, 2018 – MSDG Meeting

NJ-ACS Mass Spec Discussion Group
The NJ Mass Spectrometry Discussion Group is pleased to announce our April Monthly Meeting. NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:    Tuesday April 10, 2018

Venue:   Somerville Elks Lodge 1068       New venue! 

     375 Union Ave Bridgewater, NJ 08807

Sponsor: Agilent

Please  register here.  Registration is free, compliments of Agilent Technologies.

Program

5:30 PM    Social and Registration  
6:15 PM    Complimentary Dinner
7:00 PM    Welcome and Opening Remarks
7:05 PM    Speakers

Speaker 1:  Dr. Jun Dai

Bristol-Myers Squibb – Discovery Analytical Sciences, Lawrenceville, NJ

“A novel online capillary isoelectric focusing – mass spectrometry (cIEF-MS) method for the separation and characterization of monoclonal antibody charge variants”

Abstract for Dr. Dai:

A reliable direct online cIEF-MS method was successfully developed, for the first time, to separate and characterize charge variants of monoclonal antibodies (mAbs). The method is based on electrokinetically pumped sheath liquid nanospray CE-MS technology using a CMP EMASS-II ion source on an Agilent TOF-MS. The cIEF-MS charge profiles are well aligned with imaged cIEF-UV results and provide valuable MS information of protein charge variants. We believe that this integral cIEF-MS platform can be a crucial technology in meeting the challenges of charge variant characterization for biotherapeutics.

Speaker 2:  Dr. Erin Baker

PNNL – Richland, WA

“Increasing Molecular Coverage in Complex Biological & Environmental Samples Using Ion Mobility-Mass Spectrometry”

Abstract for Dr. Baker:

Mass spectrometry (MS)-based technologies are playing a growing role in the analysis of complex samples. Despite significant advances in MS technology, currently it is difficult to obtain measurements of both high throughput and high sensitivity for samples with great dynamic ranges such as biofluids and plant extracts. This problem ultimately results in the inability to effectively account for variation among sample conditions and/or biodiversity leading to inconsequential findings for samples which have great variation. To address this challenge, we have coupled an ion mobility separation (IMS) with MS to afford greatly improved measurement throughput, sensitivity, robustness, and quantitative capabilities for rapid analysis of complex samples. The benefits we have observed in omic studies of biological and environmental samples with IMS-MS will be summarized in this presentation.

2018-04-10

(Past Events)

Oct 18, 2017 – MSDG Meeting

NJ-ACS Mass Spec Discussion Group
The NJ Mass Spectrometry Discussion Group is pleased to announce our October Monthly Meeting.
NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:    Wednesday October 18, 2017

Venue:   Franklin Plaza Hotel   (formerly named Holiday Inn Somerset-Bridgewater)

     195 Davidson Avenue, Somerset, NJ 08873

Sponsor: Shimadzu

Shimadzu

Please  register here.  Registration is free, compliments to our sponsor.

Program

5:30 PM    Social and Registration  
6:15 PM    Complimentary Dinner
7:00 PM    Welcome and Opening Remarks
7:05 PM    Speakers

Speaker 1:  Prof. Richard B van Breemen

UIC/NIH Center for Botanical Dietary Supplements Research, University of Illinois College of Pharmacy, Chicago, IL; and Linus Pauling Institute, Oregon State University, Corvallis OR

“From the Field to the Clinic, the Role of Mass Spectrometry in Establishing Safety and Efficacy of Botanical Dietary Supplements”

Abstract for Prof van Breemen:

Mass spectrometry has become an essential tool for all stages of drug discovery and development. Similarly, mass spectrometry has broad utility in studies of the safety and efficacy of botanical dietary supplements. These applications to botanical dietary supplements include studies of the mechanisms of action (target identification and validation); identification of active natural products (drug discovery); studies of metabolism of active compounds; investigation of the potential for drug-botanical interactions (similar to studies of drug-drug interactions); and investigation of the pharmacokinetics of active compounds. Mass spectrometry is also being used in support of Phase I, II and III clinical trials of safety and efficacy of botanical dietary supplements. Preclinical and clinical examples will be drawn from studies of botanical dietary supplements such as red clover, black cohosh, hops, and licorice that are being used by menopausal women as alternatives to conventional hormone therapy.

Speaker 2:  Prof. Takeshi Bamba

Medical Institute of Bioregullation, Kyushu Univ., Fukoaka, Japan

“Metabolic profiling y supercritcal fluid extraction and separation technologies”

Abstract for Prof Takeshi Bamba:

Supercritical fluids have desirable properties like high density, low viscosity, and high diffusivity, which make them suitable mobile phases for supercritical fluid chromatography (SFC), an analytical technique that is amenable to high-throughput, high-resolution analysis. We attempted to apply SFC/MS to metabolic profiling. Furthermore, we tried to expand the range of applications of SFC for diverse compounds, including polar compounds. Additionally, we have developed supercritical fluid extraction (SFE) technologies for metabolic profiling. SFE can be used to extract labile compounds without degradation or loss. We applied SFE to the extraction of various metabolites and combined it with online SFC/MS for metabolic profiling. Furthermore, we developed a new online SFE-SFC-MS instrument.

2017-10-08

(Past Events)

Tue Sep 12, 2017 – MSDG Symposium, Poster & Vendor Show

NJ-ACS Mass Spec Discussion Group
The NJ Mass Spectrometry Discussion Group is pleased again this year to announce our “Annual NJMSDG Vendor Night, Meeting and Poster Session”.

NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

We had a fantastic turn out for our last year’s vendor show (~250 attendees) with guest lectures.

Prof Brian ChaitProf Scott A. McLuckeyThis year, we are pleased to announce that Professor Scott McLuckey, from Purdue University, will be one of our guest lecturer. The other presentation will be given by Professor Brian Chait of The Rockefeller University.

Don’t miss this incredible network, learning and cross-fertilization opportunity. Save the date!

Date:  Tuesday,  September 12, 2017

Venue: Franklin Plaza Hotel   (formerly named Holiday Inn Somerset-Bridgewater)

195 Davidson Avenue, Somerset, NJ 08873

More than 200 attendees expected

Please  register here.  Registration is free.

Program

2:30 – 3:00 PM        Vendor & Poster Set Up – Hotel Ballroom

3:00 – onwards      Registration & Vendor Show- Hotel Ballroom

3:00 – 4:30 PM        NEW!  Concurrent Workshop for Academics

4:15 – 5:00 PM        Poster Session & Cocktail Break / vendor interaction

5:00 – 5:45 PM        Prof Scott McLuckey (Purdue University)

5:45 – 7:00 PM        Buffet Dinner (raffle prizes will be announced)

7:00 – 8:00 PM        Prof Brian Chait (The Rockefeller University),

Speaker 1: Prof Scott McLuckey, PhD

Purdue University

“The Development of Electrostatic Linear Ion Traps as General Purpose Tandem Mass Spectrometers”

Abstract & Bio for Prof McLuckey:

Co-authors: Eric Dziekonski, Josh Johnson, and Kenny Lee

Abstract: We have been developing approaches to exploit the unique geometry of the linear electrostatic ion trap (ELIT) for general purpose mass spectrometry and tandem mass spectrometry. This effort has involved the implementation of ion isolation and ion activation methods along with optimization of mass analysis. A synopsis on our current status will be provided along with a detailed comparison of two complementary approaches to mass analysis that are capable of being executed simultaneously in the ELIT. One approach involves the detection of ions via image current measurement with subsequent Fourier transformation of the time-domain signal. We refer to this approach as FT-ELIT MS. Alternatively, ions can be detected after a fixed storage time via an externally mounted channelplate detector. We refer to this approach as multi-reflection time-of-flight (MR-TOF) MS. Both approaches can be used on the same ion population because the detection approaches are independent and do not interfere with one another. Based on the inherent characteristics of the two approaches, they exhibit advantages and disadvantages relative to one another, depending upon the needs of the measurement. As a result, they tend to be complementary. Currently, the FT-ELIT approach in our apparatus is capable of achieving mass resolution in excess of 100,000 FWHM at m/z 176. However, MR-TOF experiment achieves high resolution in a shorter period of time at the expense of mass range. These differences are illustrated and discussed at a fundamental level and musings on how they might be used in concert will be discussed.

Bio: Scott A. McLuckey Scott A. McLuckey received his B.S. in Chemistry at Westminster College (New Wilmington, PA) in 1978 and doctorate in Analytical Chemistry at Purdue University (West Lafayette, IN) in 1982. He then served as a Postdoctoral Fellow at the FOM Institute for Atomic and Molecular Physics (Amsterdam, The Netherlands) until late 1983. He was then awarded a Wigner Fellowship at Oak Ridge National Laboratory in the Analytical Chemistry Division. While at Oak Ridge, he served in such capacities as Group Leader, Organic and Biological Mass Spectrometry, and Head of Analytical Spectroscopy Section within the Chemical Sciences Division. In 2000, he moved to Purdue University as Professor of Chemistry. In June 2008, he was named the John A. Leighty Distinguished Professor of Chemistry at Purdue.

McLuckey’s research emphases have been placed in the areas of gas-phase ion chemistry and instrumentation for organic and biological mass spectrometry. Fundamental aspects of ionization, unimolecular reactions, and bi-molecular reactions have been studied with the goal of improving the capabilities of analytical mass spectrometry. Ion activation, ion/molecule reactions, and ion/ion reactions have been major focal areas within the context of the mass spectrometry/mass spectrometry experiment. Instrumentation for tandem mass spectrometry has also been highlighted with emphasis on electrodynamic ion traps and ion trap/hybrid instruments. This research, performed in conjunction with colleagues and post-docs at ORNL, students and post-docs at Purdue, and other collaborators, has been described in roughly 350 papers appearing in the peer-reviewed literature. He has been awarded eleven U.S. Patents on various technologies associated with mass spectrometry. The major current areas of emphasis are the identification and characterization of macro-molecules, primarily via whole molecule tandem mass spectrometry, ion/ion reaction chemistry, and the development of electrostatic ion traps for tandem mass spectrometry. Recognition for the work has included the Biemann Medal, Hites Award, and Distinguished Contribution Award from the American Society for Mass Spectrometry (ASMS), The Curt Brunneé Prize (2000) and Thomson Medal (2016) from the International Mass Spectrometry Foundation, and the Division of Analytical Chemistry Chemical Instrumentation Award and Field and Franklin Award in Mass Spectrometry from the American Chemical Society

McLuckey served as an editor of the International Journal of Mass Spectrometry from January, 1978 through December, 2016 and currently serves as an Associate Editor of Analytical Chemistry. He has co-taught short courses at the annual ASMS Conference on Fundamental Aspects of Mass Spectrometry (3 years) and Quadrupole Ion Traps (6 years). He served as VP for Programs, President, and Past-President of the ASMS from July, 2008-June 2014. He currently serves on the executive board of the International Mass Spectrometry Foundation as the North American Regional Representative.

Speaker 2: Prof Brian Chait

The Rockefeller University

“Towards a ‘Molecular Microscope’ for the Cell”

Abstract & Bio for Prof Chait:

Abstract: The myriad events that occur in living cells (replication, organellar assembly, transport, genome organization, transcription etc.) are to a large extent carried out through dynamic associations and assemblies of macromolecules. I will describe our efforts to develop and integrate sets of tools that are designed to throw light on the evolution, structure and function of these macromolecular machines.

To do this, we are developing approaches for elucidating proximal, distal, and transient protein-protein interactions in cellular milieus, as well as for determining distance restraints between amino acid residues within large protein assemblies by chemical cross-linking and mass spectrometry. The long-term goal of this research is to develop what I will loosely term a “molecular microscope” for defining cellular systems with scales spanning all the way from dimensions of the cell to atomic resolution of molecules.

Bio: Brian Chait Brian T. Chait was born in Cape Town, South Africa. He received his B. Sc. (1969) and B. Sc. (Hons) (1970) from the University of Cape Town and D.Phil. (1976) in experimental nuclear physics from Oxford University. He has spent the past 38 years at The Rockefeller University, where he is currently Camille and Henry Dreyfus Professor, heads the Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, and directs the NIH-funded National Resource for the Mass spectrometric Analysis of Biological Macromolecules, constructing novel mass spectrometers, developing useful methodologies, and applying the developed technologies to challenging biological and biomedical problems. This work is documented in 392 research papers and 31 US patents, many of which are commercialized and widely used throughout the world. These publications have been cited 48,000 times, with an average citation rate of 122 citations/paper. Professor Chait has received several awards for his research in developing instrumentation and methods for characterizing proteins, including the 2000 Bijvoet Medal, the 2002 ACS Field & Franklin Award for Outstanding Achievement in Mass Spectrometry, the 2007 HUPO 2007 Distinguished Discovery Award In Proteomics, the 2012 Per Edman Award, and the 2015 ASMS Award for a Distinguished Contribution in Mass Spectrometry.

2017-09-12

(Past Events)

Jun 28, 2017 – MSDG Meeting

NJ-ACS Mass Spec Discussion Group
The NJ Mass Spectrometry Discussion Group is pleased to announce our June Monthly Meeting.
NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:    Wednesday June 28, 2017

Venue:   Holiday Inn Somerset-Bridgewater
         195 Davidson Avenue, Somerset, NJ 08873

Sponsor: PerkinElmer

PerkinElmer

Please  register here.  Registration is free, compliments to our sponsor.

Program

5:30 PM    Social and Registration  
6:15 PM    Complimentary Dinner
7:00 PM    Welcome and Opening Remarks
7:05 PM    Speakers

Speaker 1:  Mark Greenbaum, PhD

PerkinElmer

“A Novel LC/MS-MS that is resistant to contamination from samples in difficult matrices”

Abstract & Bio for Dr Greenbaum:

A different approach to electrospray LC/MS using flow-based ion transport in to the mass spectrometer better resists changes in performance due to contamination.  Using the flow of the nebulizing gas to entrain ions in to the system eliminates the need for a high voltage ion funnel or charged capillary and eliminates a number of parameters such as desolvation potential.  The result is better long term stability, sensitivity, fewer variables and much lower maintenance.  This is especially evident with more challenging sample matrices.  The talk includes relevant application examples that demonstrate this principle and other benefits of the design.
Bio:
Mark Greenbaum has been associated with analytical chemistry and the analytical instruments industry for over 30 years.  He has been involved in LC/MS, liquid chromatography, atomic force microscopy, scientific software and others.  He worked with the inventors of the QSight LC triple quad and came to PerkinElmer with the acquisition of the technology.   His most recent work representing QSight makes him uniquely qualified to speak about the system, its use and LC-MS/MS.  Mark received his degree from the University of Maryland.

Speaker 2:  Jon Sims, Ph.D.

GlaxoSmithKline, ret.

“Known Unknowns or Unknown Unknowns? Handling Elemental Impurities Risk in Your Products by ICPMS”

Bio for Dr Sims:

Jon Sims is a career chemist and recognized expert in trace metals analysis.  Jon’s ability as a Technical Advisor will enhance and support comprehensive solutions for the new USP (U.S. Pharmacopeia) <232><233><2232> regulations.  Jon is a recently retired analytical manager from pharmaceutical giant GlaxoSmithKline, where he helped develop and implement strategies for ICH (International Conference on Harmonization) Q3D, USP <232>.  He holds a BSc (Honors)in Chemistry from Loughborough University.  He is also a member of the Royal Society of Chemistry, Association for Laboratory Automation, and acts as a referee for the Journal of Pharmaceutical Sciences.

2017-06-28

(Past Events)

May 10, 2017 – MSDG Meeting

NJ-ACS Mass Spec Discussion Group
The NJ Mass Spectrometry Discussion Group is pleased to announce our May Monthly Meeting.
NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:    Wednesday May 10, 2017

Venue:   Holiday Inn Somerset-Bridgewater
        195 Davidson Avenue, Somerset, NJ 08873

Sponsor: Bruker Daltonics

Bruker Datonics, Inc

Please  register here.  Registration is free, compliments to our sponsor.

Program

5:30 PM    Social and Registration  
6:15 PM    Complimentary Dinner
7:00 PM    Welcome and Opening Remarks
7:05 PM    Speakers

Speaker 1:  Tao He, PhD

Associate Research Fellow, BioMedicine Design, Pfizer Inc

“Impact of Ultra-High Resolution Mass Spectrometry on Early Stage Developability Assessment”

Abstract for Dr He:

Early analytical profiling has become an integral component in biologics discovery & development. This presentation will highlight the impact of applying ultra-high resolution mass spectrometry to facilitate selection and engineering of biologics leads. Approaches to minimize risks associated with chemical degradation and other biophysical properties will be discussed.

Speaker 2:  Jason Wood, Ph.D.

Market Area Manager – BioPharma, Bruker Daltonics

“Overcoming the Challenges of Intact Biotherapeutics Characterization with Ultra-High Resolution Mass Spectrometers and the Latest in Automated Biopharmaceutical Software Package – Biopharma Compass 2.0”

Abstract for Dr Wood:

Attendees of this technology seminar will hear about the latest advancements in ultrahigh-resolution time-of-flight hardware and their application to the analytical challenges facing innovators and biosimilars characterization labs.  Innovations in hardware, software and application-specific workflows will be highlighted.  In particular, the use of MALDI- and LC-TOF hardware in combination, all acquired and visualized with a single, ease-to-use, 21CFR Part 11 compliant software package; Biopharma Compass 2.0. Several case studies involving monoclonal antibodies characterization will be presented to highlight: How high-confidence (high resolution) intact/subunit workflows improves labs productivity and; how automation of routine data processing tasks improves the system utilization time.

2017-05-10

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