North Jersey Section
American Chemical Society

Mass Spectrometry Topical Group Meetings

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(Recent Event)

Jun 19, 2018 – MSDG Meeting

NJ-ACS Mass Spec Discussion Group The NJ Mass Spectrometry Discussion Group is pleased to announce our June 2018 Monthly Meeting. NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:    Tuesday, June 19, 2018

Venue:   Somerville Elks Lodge 1068

375 Union Ave Bridgewater, NJ 08807

908-707-1545

www.SomervilleElks.org

Sponsor: Thermo Fisher

Please  register here.  Registration is free, compliments of Thermo Fisher.

Program

5:30 PM    Social and Registration  
6:15 PM    Complimentary Dinner
6:55 PM    Welcome and Opening Remarks
7:05 PM    Speakers

Speaker 1:  Scott Peterman, PhD

Sr. Manager, Global Marketing for Advanced Products, Thermo Fisher

“Breaking the Bottlenecks of Small Molecule Research Using the Thermo Scientific Orbitrap ID-X Mass Spectrometer”

Abstract for Dr. Peterman:

Small molecule research covers a very broad range of applications, but all have similar experimental objectives for identifying and characterizing the compounds of interest to evaluate the stated research objective. Similarly, all applications face bottlenecks associated with exhaustively sampling compounds of interest in the presence of the background matrix, efficiently isolating and fragmenting each compound to generate high-quality, product ion rich spectral ion trees, and confidently automating the data processing to significantly increase the conversion of unknown unknowns to knowns. This presentation will highlight the new workflows focused on small molecules with our new tribrid mass spectrometer. The workflow components enable complex methods to be easily created, employed in automated sequence analysis routines, and demonstrations of the data processing routines used for compound identification and structural elucidation, regardless of the user expertise.

Speaker 2:  Debadeep Bhattacharyya

Sr. Manager, Marketing, Clinical Research and Forensic Toxicology, Thermo Fisher

“Confident Quantitation – Addressing Today’s and Tomorrow’s Challenges”

Abstract for Dr. Bhattacharyya:

While quantitative analysis of critical analytes in different matrices has been around for several years now, the growing complications in types of analytes and complexities of matrices continue to pose challenges to every analytical scientist focused on developing quantitative workflows. This presentation will highlight the benefits of a comprehensive workflows focused on targeted quantitation with our new generation Triple Quadrupole MS platforms. These workflows enable development of robust, reliable, reproducible, quantitative workflows for every molecule type, in every matrix regardless of the user expertise.

2018-06-19

(Past Event)

May 9, 2018 – MSDG Meeting

NJ-ACS Mass Spec Discussion Group The NJ Mass Spectrometry Discussion Group is pleased to announce our May Monthly Meeting. NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:    Wednesday May 9, 2018

Venue:   Somerville Elks Lodge 1068       Note venue! 

375 Union Ave Bridgewater, NJ 08807

(908-707-1545)

Sponsor:       Bruker Daltonics

Please  register here.  Registration is free, compliments of Bruker Daltonics.

Program

5:30 PM    Social and Registration  
6:15 PM    Complimentary Dinner
6:55 PM    Welcome and Opening Remarks
7:05 PM    Speakers

Speaker 1: Prof. Leonard Foster, PhD

University of British Columbia, Vancouver, BC

“Exploring tissue-specific interactomes using PCP-SILAC”

Abstract for Dr. Foster:

An interactome describes the global organization of protein interactions within a cell. Protein correlation profiling (PCP) uses precise co-elution of two proteins as evidence that they interact. This high-throughput technique does not require overexpression or the creation of fusion proteins. We have created a SILAC mouse and used it to construct the interactomes of seven different tissues based on PCP. These data now allow us to ask several questions, including specialization of tissues at the interactome level, whether disease-causing mutations might perturb the interaction network in pathogenesis and the level of accuracy of computational predictions of interaction networks. This presentation will focus on the latest developments in interactome mapping from our laboratory.

Speaker 2:  Gary Kruppa, PhD

Vice President Proteomics, Bruker Daltonics Inc

“The timsTOF Pro Powered by PASEF: Digging Deeper into the Proteome with Record-breaking Speed, Sensitivity and Robustness”

Abstract for Dr. Kruppa:

Parallel Accumulation Serial Fragmentation (PASEF, Meier et al., JPR 2015, PMID: 26538118) for trapped ion mobility spectrometry (TIMS) quadrupole time of flight (QTOF) instruments enables 5-10X faster data-dependent acquisition of fragment ion spectra in bottom up shotgun proteomics. We have now implemented PASEF on a new instrument, the timsTOF Pro, and achieved deeper proteome coverage, as well as impressive gains in sensitivity and sample efficiency due to the 100% duty cycle and focusing of the ions in time and space provided by TIMS and the PASEF method. In this talk we will cover the principles of TIMS and PASEF and describe how these gains in speed and sensitivity are obtained. The impact of this method on instrument time and sample amount vs proteome depth in data-dependent shotgun proteomics experiments will be discussed.

2018-05-09

(Past Event)

Apr 10, 2018 – MSDG Meeting

NJ-ACS Mass Spec Discussion Group
The NJ Mass Spectrometry Discussion Group is pleased to announce our April Monthly Meeting. NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:    Tuesday April 10, 2018

Venue:   Somerville Elks Lodge 1068       New venue! 

     375 Union Ave Bridgewater, NJ 08807

Sponsor: Agilent

Please  register here.  Registration is free, compliments of Agilent Technologies.

Program

5:30 PM    Social and Registration  
6:15 PM    Complimentary Dinner
7:00 PM    Welcome and Opening Remarks
7:05 PM    Speakers

Speaker 1:  Dr. Jun Dai

Bristol-Myers Squibb – Discovery Analytical Sciences, Lawrenceville, NJ

“A novel online capillary isoelectric focusing – mass spectrometry (cIEF-MS) method for the separation and characterization of monoclonal antibody charge variants”

Abstract for Dr. Dai:

A reliable direct online cIEF-MS method was successfully developed, for the first time, to separate and characterize charge variants of monoclonal antibodies (mAbs). The method is based on electrokinetically pumped sheath liquid nanospray CE-MS technology using a CMP EMASS-II ion source on an Agilent TOF-MS. The cIEF-MS charge profiles are well aligned with imaged cIEF-UV results and provide valuable MS information of protein charge variants. We believe that this integral cIEF-MS platform can be a crucial technology in meeting the challenges of charge variant characterization for biotherapeutics.

Speaker 2:  Dr. Erin Baker

PNNL – Richland, WA

“Increasing Molecular Coverage in Complex Biological & Environmental Samples Using Ion Mobility-Mass Spectrometry”

Abstract for Dr. Baker:

Mass spectrometry (MS)-based technologies are playing a growing role in the analysis of complex samples. Despite significant advances in MS technology, currently it is difficult to obtain measurements of both high throughput and high sensitivity for samples with great dynamic ranges such as biofluids and plant extracts. This problem ultimately results in the inability to effectively account for variation among sample conditions and/or biodiversity leading to inconsequential findings for samples which have great variation. To address this challenge, we have coupled an ion mobility separation (IMS) with MS to afford greatly improved measurement throughput, sensitivity, robustness, and quantitative capabilities for rapid analysis of complex samples. The benefits we have observed in omic studies of biological and environmental samples with IMS-MS will be summarized in this presentation.

2018-04-10

(Past Event)

Oct 18, 2017 – MSDG Meeting

NJ-ACS Mass Spec Discussion Group
The NJ Mass Spectrometry Discussion Group is pleased to announce our October Monthly Meeting.
NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:    Wednesday October 18, 2017

Venue:   Franklin Plaza Hotel   (formerly named Holiday Inn Somerset-Bridgewater)

     195 Davidson Avenue, Somerset, NJ 08873

Sponsor: Shimadzu

Shimadzu

Please  register here.  Registration is free, compliments to our sponsor.

Program

5:30 PM    Social and Registration  
6:15 PM    Complimentary Dinner
7:00 PM    Welcome and Opening Remarks
7:05 PM    Speakers

Speaker 1:  Prof. Richard B van Breemen

UIC/NIH Center for Botanical Dietary Supplements Research, University of Illinois College of Pharmacy, Chicago, IL; and Linus Pauling Institute, Oregon State University, Corvallis OR

“From the Field to the Clinic, the Role of Mass Spectrometry in Establishing Safety and Efficacy of Botanical Dietary Supplements”

Abstract for Prof van Breemen:

Mass spectrometry has become an essential tool for all stages of drug discovery and development. Similarly, mass spectrometry has broad utility in studies of the safety and efficacy of botanical dietary supplements. These applications to botanical dietary supplements include studies of the mechanisms of action (target identification and validation); identification of active natural products (drug discovery); studies of metabolism of active compounds; investigation of the potential for drug-botanical interactions (similar to studies of drug-drug interactions); and investigation of the pharmacokinetics of active compounds. Mass spectrometry is also being used in support of Phase I, II and III clinical trials of safety and efficacy of botanical dietary supplements. Preclinical and clinical examples will be drawn from studies of botanical dietary supplements such as red clover, black cohosh, hops, and licorice that are being used by menopausal women as alternatives to conventional hormone therapy.

Speaker 2:  Prof. Takeshi Bamba

Medical Institute of Bioregullation, Kyushu Univ., Fukoaka, Japan

“Metabolic profiling y supercritcal fluid extraction and separation technologies”

Abstract for Prof Takeshi Bamba:

Supercritical fluids have desirable properties like high density, low viscosity, and high diffusivity, which make them suitable mobile phases for supercritical fluid chromatography (SFC), an analytical technique that is amenable to high-throughput, high-resolution analysis. We attempted to apply SFC/MS to metabolic profiling. Furthermore, we tried to expand the range of applications of SFC for diverse compounds, including polar compounds. Additionally, we have developed supercritical fluid extraction (SFE) technologies for metabolic profiling. SFE can be used to extract labile compounds without degradation or loss. We applied SFE to the extraction of various metabolites and combined it with online SFC/MS for metabolic profiling. Furthermore, we developed a new online SFE-SFC-MS instrument.

2017-10-08

(Past Event)

Tue Sep 12, 2017 – MSDG Symposium, Poster & Vendor Show

NJ-ACS Mass Spec Discussion Group
The NJ Mass Spectrometry Discussion Group is pleased again this year to announce our “Annual NJMSDG Vendor Night, Meeting and Poster Session”.

NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

We had a fantastic turn out for our last year’s vendor show (~250 attendees) with guest lectures.

Prof Brian ChaitProf Scott A. McLuckeyThis year, we are pleased to announce that Professor Scott McLuckey, from Purdue University, will be one of our guest lecturer. The other presentation will be given by Professor Brian Chait of The Rockefeller University.

Don’t miss this incredible network, learning and cross-fertilization opportunity. Save the date!

Date:  Tuesday,  September 12, 2017

Venue: Franklin Plaza Hotel   (formerly named Holiday Inn Somerset-Bridgewater)

195 Davidson Avenue, Somerset, NJ 08873

More than 200 attendees expected

Please  register here.  Registration is free.

Program

2:30 – 3:00 PM        Vendor & Poster Set Up – Hotel Ballroom

3:00 – onwards      Registration & Vendor Show- Hotel Ballroom

3:00 – 4:30 PM        NEW!  Concurrent Workshop for Academics

4:15 – 5:00 PM        Poster Session & Cocktail Break / vendor interaction

5:00 – 5:45 PM        Prof Scott McLuckey (Purdue University)

5:45 – 7:00 PM        Buffet Dinner (raffle prizes will be announced)

7:00 – 8:00 PM        Prof Brian Chait (The Rockefeller University),

Speaker 1: Prof Scott McLuckey, PhD

Purdue University

“The Development of Electrostatic Linear Ion Traps as General Purpose Tandem Mass Spectrometers”

Abstract & Bio for Prof McLuckey:

Co-authors: Eric Dziekonski, Josh Johnson, and Kenny Lee

Abstract: We have been developing approaches to exploit the unique geometry of the linear electrostatic ion trap (ELIT) for general purpose mass spectrometry and tandem mass spectrometry. This effort has involved the implementation of ion isolation and ion activation methods along with optimization of mass analysis. A synopsis on our current status will be provided along with a detailed comparison of two complementary approaches to mass analysis that are capable of being executed simultaneously in the ELIT. One approach involves the detection of ions via image current measurement with subsequent Fourier transformation of the time-domain signal. We refer to this approach as FT-ELIT MS. Alternatively, ions can be detected after a fixed storage time via an externally mounted channelplate detector. We refer to this approach as multi-reflection time-of-flight (MR-TOF) MS. Both approaches can be used on the same ion population because the detection approaches are independent and do not interfere with one another. Based on the inherent characteristics of the two approaches, they exhibit advantages and disadvantages relative to one another, depending upon the needs of the measurement. As a result, they tend to be complementary. Currently, the FT-ELIT approach in our apparatus is capable of achieving mass resolution in excess of 100,000 FWHM at m/z 176. However, MR-TOF experiment achieves high resolution in a shorter period of time at the expense of mass range. These differences are illustrated and discussed at a fundamental level and musings on how they might be used in concert will be discussed.

Bio: Scott A. McLuckey Scott A. McLuckey received his B.S. in Chemistry at Westminster College (New Wilmington, PA) in 1978 and doctorate in Analytical Chemistry at Purdue University (West Lafayette, IN) in 1982. He then served as a Postdoctoral Fellow at the FOM Institute for Atomic and Molecular Physics (Amsterdam, The Netherlands) until late 1983. He was then awarded a Wigner Fellowship at Oak Ridge National Laboratory in the Analytical Chemistry Division. While at Oak Ridge, he served in such capacities as Group Leader, Organic and Biological Mass Spectrometry, and Head of Analytical Spectroscopy Section within the Chemical Sciences Division. In 2000, he moved to Purdue University as Professor of Chemistry. In June 2008, he was named the John A. Leighty Distinguished Professor of Chemistry at Purdue.

McLuckey’s research emphases have been placed in the areas of gas-phase ion chemistry and instrumentation for organic and biological mass spectrometry. Fundamental aspects of ionization, unimolecular reactions, and bi-molecular reactions have been studied with the goal of improving the capabilities of analytical mass spectrometry. Ion activation, ion/molecule reactions, and ion/ion reactions have been major focal areas within the context of the mass spectrometry/mass spectrometry experiment. Instrumentation for tandem mass spectrometry has also been highlighted with emphasis on electrodynamic ion traps and ion trap/hybrid instruments. This research, performed in conjunction with colleagues and post-docs at ORNL, students and post-docs at Purdue, and other collaborators, has been described in roughly 350 papers appearing in the peer-reviewed literature. He has been awarded eleven U.S. Patents on various technologies associated with mass spectrometry. The major current areas of emphasis are the identification and characterization of macro-molecules, primarily via whole molecule tandem mass spectrometry, ion/ion reaction chemistry, and the development of electrostatic ion traps for tandem mass spectrometry. Recognition for the work has included the Biemann Medal, Hites Award, and Distinguished Contribution Award from the American Society for Mass Spectrometry (ASMS), The Curt Brunneé Prize (2000) and Thomson Medal (2016) from the International Mass Spectrometry Foundation, and the Division of Analytical Chemistry Chemical Instrumentation Award and Field and Franklin Award in Mass Spectrometry from the American Chemical Society

McLuckey served as an editor of the International Journal of Mass Spectrometry from January, 1978 through December, 2016 and currently serves as an Associate Editor of Analytical Chemistry. He has co-taught short courses at the annual ASMS Conference on Fundamental Aspects of Mass Spectrometry (3 years) and Quadrupole Ion Traps (6 years). He served as VP for Programs, President, and Past-President of the ASMS from July, 2008-June 2014. He currently serves on the executive board of the International Mass Spectrometry Foundation as the North American Regional Representative.

Speaker 2: Prof Brian Chait

The Rockefeller University

“Towards a ‘Molecular Microscope’ for the Cell”

Abstract & Bio for Prof Chait:

Abstract: The myriad events that occur in living cells (replication, organellar assembly, transport, genome organization, transcription etc.) are to a large extent carried out through dynamic associations and assemblies of macromolecules. I will describe our efforts to develop and integrate sets of tools that are designed to throw light on the evolution, structure and function of these macromolecular machines.

To do this, we are developing approaches for elucidating proximal, distal, and transient protein-protein interactions in cellular milieus, as well as for determining distance restraints between amino acid residues within large protein assemblies by chemical cross-linking and mass spectrometry. The long-term goal of this research is to develop what I will loosely term a “molecular microscope” for defining cellular systems with scales spanning all the way from dimensions of the cell to atomic resolution of molecules.

Bio: Brian Chait Brian T. Chait was born in Cape Town, South Africa. He received his B. Sc. (1969) and B. Sc. (Hons) (1970) from the University of Cape Town and D.Phil. (1976) in experimental nuclear physics from Oxford University. He has spent the past 38 years at The Rockefeller University, where he is currently Camille and Henry Dreyfus Professor, heads the Laboratory of Mass Spectrometry and Gaseous Ion Chemistry, and directs the NIH-funded National Resource for the Mass spectrometric Analysis of Biological Macromolecules, constructing novel mass spectrometers, developing useful methodologies, and applying the developed technologies to challenging biological and biomedical problems. This work is documented in 392 research papers and 31 US patents, many of which are commercialized and widely used throughout the world. These publications have been cited 48,000 times, with an average citation rate of 122 citations/paper. Professor Chait has received several awards for his research in developing instrumentation and methods for characterizing proteins, including the 2000 Bijvoet Medal, the 2002 ACS Field & Franklin Award for Outstanding Achievement in Mass Spectrometry, the 2007 HUPO 2007 Distinguished Discovery Award In Proteomics, the 2012 Per Edman Award, and the 2015 ASMS Award for a Distinguished Contribution in Mass Spectrometry.

2017-09-12

(Past Event)

Jun 28, 2017 – MSDG Meeting

NJ-ACS Mass Spec Discussion Group
The NJ Mass Spectrometry Discussion Group is pleased to announce our June Monthly Meeting.
NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:    Wednesday June 28, 2017

Venue:   Holiday Inn Somerset-Bridgewater
         195 Davidson Avenue, Somerset, NJ 08873

Sponsor: PerkinElmer

PerkinElmer

Please  register here.  Registration is free, compliments to our sponsor.

Program

5:30 PM    Social and Registration  
6:15 PM    Complimentary Dinner
7:00 PM    Welcome and Opening Remarks
7:05 PM    Speakers

Speaker 1:  Mark Greenbaum, PhD

PerkinElmer

“A Novel LC/MS-MS that is resistant to contamination from samples in difficult matrices”

Abstract & Bio for Dr Greenbaum:

A different approach to electrospray LC/MS using flow-based ion transport in to the mass spectrometer better resists changes in performance due to contamination.  Using the flow of the nebulizing gas to entrain ions in to the system eliminates the need for a high voltage ion funnel or charged capillary and eliminates a number of parameters such as desolvation potential.  The result is better long term stability, sensitivity, fewer variables and much lower maintenance.  This is especially evident with more challenging sample matrices.  The talk includes relevant application examples that demonstrate this principle and other benefits of the design.
Bio:
Mark Greenbaum has been associated with analytical chemistry and the analytical instruments industry for over 30 years.  He has been involved in LC/MS, liquid chromatography, atomic force microscopy, scientific software and others.  He worked with the inventors of the QSight LC triple quad and came to PerkinElmer with the acquisition of the technology.   His most recent work representing QSight makes him uniquely qualified to speak about the system, its use and LC-MS/MS.  Mark received his degree from the University of Maryland.

Speaker 2:  Jon Sims, Ph.D.

GlaxoSmithKline, ret.

“Known Unknowns or Unknown Unknowns? Handling Elemental Impurities Risk in Your Products by ICPMS”

Bio for Dr Sims:

Jon Sims is a career chemist and recognized expert in trace metals analysis.  Jon’s ability as a Technical Advisor will enhance and support comprehensive solutions for the new USP (U.S. Pharmacopeia) <232><233><2232> regulations.  Jon is a recently retired analytical manager from pharmaceutical giant GlaxoSmithKline, where he helped develop and implement strategies for ICH (International Conference on Harmonization) Q3D, USP <232>.  He holds a BSc (Honors)in Chemistry from Loughborough University.  He is also a member of the Royal Society of Chemistry, Association for Laboratory Automation, and acts as a referee for the Journal of Pharmaceutical Sciences.

2017-06-28

(Past Event)

May 10, 2017 – MSDG Meeting

NJ-ACS Mass Spec Discussion Group
The NJ Mass Spectrometry Discussion Group is pleased to announce our May Monthly Meeting.
NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:    Wednesday May 10, 2017

Venue:   Holiday Inn Somerset-Bridgewater
        195 Davidson Avenue, Somerset, NJ 08873

Sponsor: Bruker Daltonics

Bruker Datonics, Inc

Please  register here.  Registration is free, compliments to our sponsor.

Program

5:30 PM    Social and Registration  
6:15 PM    Complimentary Dinner
7:00 PM    Welcome and Opening Remarks
7:05 PM    Speakers

Speaker 1:  Tao He, PhD

Associate Research Fellow, BioMedicine Design, Pfizer Inc

“Impact of Ultra-High Resolution Mass Spectrometry on Early Stage Developability Assessment”

Abstract for Dr He:

Early analytical profiling has become an integral component in biologics discovery & development. This presentation will highlight the impact of applying ultra-high resolution mass spectrometry to facilitate selection and engineering of biologics leads. Approaches to minimize risks associated with chemical degradation and other biophysical properties will be discussed.

Speaker 2:  Jason Wood, Ph.D.

Market Area Manager – BioPharma, Bruker Daltonics

“Overcoming the Challenges of Intact Biotherapeutics Characterization with Ultra-High Resolution Mass Spectrometers and the Latest in Automated Biopharmaceutical Software Package – Biopharma Compass 2.0”

Abstract for Dr Wood:

Attendees of this technology seminar will hear about the latest advancements in ultrahigh-resolution time-of-flight hardware and their application to the analytical challenges facing innovators and biosimilars characterization labs.  Innovations in hardware, software and application-specific workflows will be highlighted.  In particular, the use of MALDI- and LC-TOF hardware in combination, all acquired and visualized with a single, ease-to-use, 21CFR Part 11 compliant software package; Biopharma Compass 2.0. Several case studies involving monoclonal antibodies characterization will be presented to highlight: How high-confidence (high resolution) intact/subunit workflows improves labs productivity and; how automation of routine data processing tasks improves the system utilization time.

2017-05-10

(Past Event)

Apr 12, 2017 – MSDG Meeting

NJ-ACS Mass Spec Discussion Group

The NJ Mass Spectrometry Discussion Group is pleased to announce our April Monthly Meeting.

NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:    Wednesday April 12, 2017

Venue:   Holiday Inn Somerset-Bridgewater
        195 Davidson Avenue, Somerset, NJ 08873

Sponsor: SCIEX

SCIEX


Please  register here.  Registration is free.

Program

5:30 PM    Social and Registration  
6:15 PM    Complimentary Dinner
7:00 PM    Welcome and Opening Remarks
7:05 PM    Speakers

Speaker 1:  Melanie Juba, PhD

Advanced Workflow Specialist, SCIEX

“The Simpler and Faster Solution for Routine Biopharmaceutical Characterization”

Abstract:

The X500B QTOF is a new instrument and software solution that improves robustness and reliability, reduces complexity and streamlines analysis workflows so that everyone using the instrument can get expert results. It is the first true benchtop, high-resolution mass spectrometer purpose-built for biologics characterization. Combining intuitive and powerful new software tools with a robust, reliable, and compact instrument, the X500B system is specifically designed to make characterization tasks simpler and to get biotherapeutic characterization answers faster.

Speaker 2:  Ian Moore, Ph.D.

Global Technical Marketing Manager, Pharma Quant and MetID, SCIEX

“Confident and Powerful MetID for all Your Therapeutic Molecules”

Abstract:

The SCIEX Biotransform Solution featuring the new MetabolitePilot 2.0 software is a powerful combination of hardware and software that will accelerate MetID by providing automated metabolite structure generation and a dedicated workflow for peptides and ADCs. Featuring SWATH data-independent acquisition on either the TripleTOF 6600 system or X500 QTOF system, the SCIEX Biotransform Solution ensures consistent and reproducible MS/MS are collected for all detectable species, resulting in reliable detection and identification from a single injection. With brand new workflows for peptides and ADCs and multiple peak finding strategies utilizing MS and MS/MS information MetabolitePilot 2.0 software is specifically designed to make MetID for these complex molecules simpler and easier.

2017-04-12

(Past Event)

Mar 20, 2017 – MSDG Meeting

Note:  This meeting was rescheduled from March 14 due to a snowstorm.

NJ-ACS Mass Spec Discussion Group

The NJ Mass Spectrometry Discussion Group is pleased to announce our March Monthly Meeting.

NJ MSDG is the second largest mass spectrometry professional association in the nation behind ASMS, with over 1,100 members in the tristate area. [ homepage ]

Date:    Monday March 20, 2017

Venue:   Holiday Inn Somerset-Bridgewater
        195 Davidson Avenue, Somerset, NJ 08873

Sponsor: Waters

Waters

Please  register here.  Registration is free.

Program

5:30 PM    Social and Registration  
6:15 PM    Complimentary Dinner
7:00 PM    Welcome and Opening Remarks
7:05 PM    Speakers

Speaker 1:  Guodong Chen

Bioanalytical and Discovery Analytical Sciences, Pharmaceutical Candidate Optimization, Research and Development, Bristol-Myers Squibb Company

“Applications of Mass Spectrometry in Analytical Characterization of Biologics”

Abstract for Dr Chen:

Since the introduction of the first recombinant DNA-derived protein insulin in the 1980s and the launch of Interferons and Interleukins in the 1990s, biologics market has shown a healthy growth. This is largely due to advances in recombinant DNA technology that have provided the means to produce therapeutic proteins. Mass spectrometry is uniquely positioned to cope with additional challenges for the analysis of biologics, due to its analytical sensitivity and specificity. This presentation will present current status and trends in MS characterization of biologics, including primary structural analysis and higher order structure characterization.

Speaker 2:  Min Du

Sr. Biopharmaceutical Business Development Manager, Waters Corporation

“Deploying a Fit for Purpose LCMS Platform in Regulated Development and QC for Multi-Attribute Monitoring”

Abstract for Dr Du:

High resolution analytical technologies are moving out of the realm of characterization and into the regulated environments of late development, manufacturing and QC organizations. Analytical managers are now challenged to not only develop an effective characterization strategy, but participate in the lifecycle planning of those assays as they evolve into attribute monitoring, and validated release assays for a commercial product. Harmonization of platforms across these organizations has remained a challenge to this process, but the development of platforms for both high resolution and routine nominal mass detection that can be deployed across an entire organization have fueled great interest progressing LCMS analysis later in development and into QC organizations. While peptide-centric monitoring of multiple product variants has recently generated great interest and concerns, there is already a progression of developing and validating intact/subunit mass profiling QC release assays. In this seminar, we will discuss the benefits of applying the HRMS QTof platform under UNIFI for comprehensive primary structural characterization in support discovery and development efforts, transitioning this platform into regulated late development with a mix of targeted monitoring and new variant identification workflow, and multiple strategies at the intact/subunit mass and peptide map level for effective deployment of critical assays into a QC-lot release environment.

2017-03-20

(Past Event)

Mar 14, 2017 – MSDG Meeting

Note:  This event was postponed to March 20 due to snowstorm.

2017-03-14

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